Influence of Quercetin on the Recurrence of Tumor After Liver Cancer Resection in Athymic Mice and its Mechanism

Chen Peng; Yang Xi Jun; Li Chun Man; Liu Feng; A Yong Jun

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Chen Peng , Yang Xi Jun , Li Chun Man , Liu Feng , A Yong Jun . Influence of Quercetin on the Recurrence of Tumor After Liver Cancer Resection in Athymic Mice and its Mechanism[J]. Journal of Kunming Medical University, 2017, 38(11): 25-28.

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Chen Peng , Yang Xi Jun , Li Chun Man , Liu Feng , A Yong Jun . Influence of Quercetin on the Recurrence of Tumor After Liver Cancer Resection in Athymic Mice and its Mechanism[J]. Journal of Kunming Medical University, 2017, 38(11): 25-28.

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Influence of Quercetin on the Recurrence of Tumor After Liver Cancer Resection in Athymic Mice and its Mechanism

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基金：云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目 (2014FZ025); 云南省教育厅科学研究基金资助项目 (2014Z065);

Received Date: 2017-04-17

Abstract

Abstract

Objective To study the impact of quercetin on tumor recurrence after hepatectomy in athymic mouse hepatoma and the mechanism.Methods We established high-recurrent athymic mouse model simulating post-operation human HCC.For experimental group, we administered the mice with quercetin solution 75 mg/ (kg.d) by gavage, and observed tumor recurrence of the mice.Then we detected the expression of MMP-2, TIMP-2 in recurrent tumor using Western-blot.Results Compared with control group, mice in quercetin group had smaller liver recurrent focus volumn [ (25.49±9.78) mm3 VS (49.75±7.53) mm3, P<0.05) ], less liver recurrent focus[ (1.00±0.71) vs (2.20±0.84) , P<0.05].Western-blot was used to detect the expression of P65, MMP-2 and E-Cadherin.Compared with control group, the P65 and MMP-2 expression of the recurrent tumor in quercetin group decreased [ (170.07±6.61) vs (156.26±8.60) , P<0.05], [ (169.21±5.32) vs (158.17±4.80) , P<0.05], and the E-Cadherin expression in quercetin group increased [ (136.24±3.03) vs (144.70±5.02) , P<0.05].Conclusions Quercetin could restrain tumor recurrence in athymic mice after hepatectomy.The mechanism may be that quercetin could decrease the expression of P65 and MMP-2 and increase the expression of E-Cadherin in recurrent tumor.
- Quercetin,
- Hepatectomy,
- Recurrence,
- P65,
- MMP-2,
- E-Cadherin

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References(10)

References

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