The Advanced Progress on the Analgesic Mechanism of Oxytocin

Luo Ya Fan; Li Guo Ping; Chen Shao Chun; Han Yi

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Luo Ya Fan , Li Guo Ping , Chen Shao Chun , Han Yi . The Advanced Progress on the Analgesic Mechanism of Oxytocin[J]. Journal of Kunming Medical University, 2018, 39(01): 1-4.

Citation:

Luo Ya Fan , Li Guo Ping , Chen Shao Chun , Han Yi . The Advanced Progress on the Analgesic Mechanism of Oxytocin[J]. Journal of Kunming Medical University, 2018, 39(01): 1-4.

Luo Ya Fan , Li Guo Ping , Chen Shao Chun , Han Yi . The Advanced Progress on the Analgesic Mechanism of Oxytocin[J]. Journal of Kunming Medical University, 2018, 39(01): 1-4.

Citation:

Luo Ya Fan , Li Guo Ping , Chen Shao Chun , Han Yi . The Advanced Progress on the Analgesic Mechanism of Oxytocin[J]. Journal of Kunming Medical University, 2018, 39(01): 1-4.

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The Advanced Progress on the Analgesic Mechanism of Oxytocin

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作者简介：韩毅, 男, 49岁, 副教授, 硕士研究生导师.1993年毕业于昆明医学院临床医学专业, 现为昆明医科大学基础医学院副院长, 云南省生理科学会理事长、中国生理学会理事.专业方向为循环生理、神经生理;研究方向为心肌缺血的信号通路研究、痛觉调制及镇痛机制研究.主持云南省科技厅-昆明医科大学联合项目1项, 参与国家自然科学基金项目3项、云南省科技厅-昆明医科大学联合重点项目1项.近年来发表论文10余篇, 其中SCI收录论文7篇.E-mail:kmhanyi@163.com; 罗雅范 (1992~) , 女, 四川雅安市人, 在读硕士研究生, 主要从事镇痛机制研究工作.; 陈绍春.E-mail:shaochunchen@126.com;

基金：国家自然科学基金资助项目 (81260195, 81302362);

Received Date: 2017-09-12

Abstract

Abstract

Oxytocin (OT) is a 9-amino-peptide hormone synthesized mainly in the Paraventricular Nucleus (PVN) and Supraoptic Nucleus (SON) of mammals’hypothalamus.Small part of OT is synthesized in peripheral organs.In addition to promoting the lactation and uterine contraction, OT has many other physiological functions, such as analgesia.It has been proved that neuropeptide can exert analgesic effect.OT is indeed a neuropeptide secreted naturally by mammals.Sdudies have shown that OT plays an important role in relieving pain and can avoid problems like addiction and other side effects.However, its underlying mechanism of analgia is still unclear.Therefore, further study of the analgesic mechanism of oxytocin has a great theoretic significance and very broad clinical prosperities.
- Oxytocin,
- Analgesia,
- Mechanism

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References(23)

References

[1]刘柳, 汪晴川, 盖冬玮, 等.利鲁唑在神经保护、镇痛及抗抑郁领域的研究进展[J].化学与生物工程, 2017, 34 (2) :6-9.
[2]刘超斌, 王梅英, 李东舫.催产素的研究进展[J].中华妇产科杂志, 1999, 34 (5) :55-57.
[3]	[3]OHMICHI M, OIKE K, NOHARA A, et al.Oxytocin stimulates mitogen-activated protein kinase activity in cultured human puerperal uterine myometrial cells[J].Endocrinology, 1995, 136 (5) :2082-2087.
[4]	[4]KU C, QIAN A, WEN Y, et al.Oxytocin stimulates myometrial guanosine triphosphatase and phospholipase-Cactivities via coupling to G alpha q/11[J].Endocrinology, 1995, 136 (4) :1509-1515.
[5]	[5]GAO L, YU C.Involvement of opioid receptors in the oxytocin-induced antinociception in the central nervous system of rats[J].Regulatory Peptides, 2004, 120 (1-3) :53-58.
[6]	[6]YANG J, YANG Y, CHEN M, et al.Central oxytocin enhances antinociception in the rat[J].Peptides, 2007, 28 (5) :1113-1119.
[7]	[7]MADRAZO I, FRANCO-BOURLAND R, LEON-MEZAV M, et al.Intraventricular somatostatin-14, arginine vasopressin, and oxytocin:analgesic effect in a patient with intractable cancer pain[J].Stereot actic&Functional Neurosurgery, 1987, 50 (1-6) :427-431.
[8]	[8]YANG J.Intrathecal administration of oxytocin induces analgesia in low back pain involving the endogenous opiate peptide system[J].Spine, 1994, 19 (8) :867-871.
[9]	[9]S.Q.YU, T.LUNDEBERG, L.C.YU.Involvement of oxytocin in spinal antinociception in rats with inflammation[J].Brain Research, 2003, 983 (12) :13-22.
[10]	[10]CHOW L H, TAO P L, CHEN J C, et al.A possible correlation between oxytocin-induced and angiotensin IV-induced anti-hyperalgesia at the spinal level in rats[J].Peptides, 2013, 39 (1) :21-28.
[11]	[11]ROJASPILONI G, GERARDO R P, MEJIARODRIGUEZR, et al.Oxytocin, but not vassopressin, modulates nociceptive responses in dorsal horn neurons[J].Neuroscience Letters, 2010, 476 (1) :32-35.
[12]	[12]OODIN B R, NESS T J, ROBBINS M T.Oxytocin Amultifunctional analgesic for chronic deep tissue pain[J].Current Pharmaceutical Design, 2015, 21 (7) :906-913.
[13]	[13]MARTINEZ-LORENZANA G, ESPINOSALOSALOPEZ I, CARRANZA M, et al.PVN electrical stimulation prolongs withdrawal latencies and releases oxytocin in cerebrospinal fluid, plasma, and spinal cord tissue in intact and neuropathic rats[J].Pain, 2008, 140 (2) :265-273.
[14]	[14]TACHE Y, CHOW L H, CHEN Y H, et al.Sex difference in oxytocin-induced anti-hyperalgesia at the spinal level in rats with intraplantar carrageenan-induced inflammation[J].Plos One, 2016, 11 (9) :e0162218.
[15]	[15] ELIAVA M, MELCHIOR M, KNOBLOCH-BOLLMANNH S, et al.A new population of parvocellular oxytocin neurons controlling magnocellular neuron activity and inflammatory pain processing[J].Neuron, 2016, 89 (6) :1291-1304.
[16]高庆军, 孟凡竹, 刘巍, 等.催产素在侧脑室内对正常大鼠的镇痛作用[J].中国妇幼保健, 2014, 29 (31) :5154-5157.
[17]	[17]HUBER D, VEINANTE P, STOOP R.Vasopressin and oxytocin excite distinct neuronal populations in the central amygdala.[J].Science, 2005, 308 (5719) :245-248.
[18]	[18]BRETON J D, POISBEAU P, DARBON P.Antinociceptive action of oxytocin involves inhibition of potassium channel currents in lamina II neurons of the rat spinal cord[J].Molecular Pain, 2009, 5 (1) :63-74.
[19]	[19]JIANG C Y, FUJITA T, KUMAMOTO E.Synaptic modulation and inward current produced by oxytocin in substantia gelatinosa neurons of adult rat spinal cord slices[J].Journal of Neurophysiology, 2014, 111 (5) :991-1007.
[20]	[20]HOBO S, HAYASHIDA K, EISENACH J C.Oxytocin inhibits the membrane depolarization-induced increase in intracellular calcium in capsaicin sensitive sensory neurons:a peripheral mechanism of analgesic action[J].Anesthesia&Analgesia, 2012, 114 (2) :442-449.
[21]	[21]TZABAZIS A, MECHANIC J, MILLER J, et al.Oxytocin receptor:Expression in the trigeminal nociceptive system and potential role in the treatment of headache disorders[J].Cephalalgia An International Journal of Headache, 2015, 36 (10) :943-950.
[22]	[22]RADDANT A C, RUSSO A F.Calcitonin gene-related peptide in migraine:intersection of peripheral inflammation and central modulation[J].Expert Reviews in Molecular Medicine, 2011, 13 (201) :e36.
[23]	[23]ELIAVA M, MELCHIOR M, KNOBLOCH-BOLLMANNH S, et al.A New Population of Parvocellular Oxytocin Neurons Controlling Magnocellular Neuron Activity and Inflammatory Pain Processing[J].Neuron, 2016, 89 (6) :1291-1304.

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