Zhou Xiao Nan , Song Xue Lan , Yang Yuan , Ma Chen Jing , He Fang Yan . Advances and Applications in Gene Silencing[J]. Journal of Kunming Medical University, 2018, 39(01): 131-135.
Citation: Zhou Xiao Nan , Song Xue Lan , Yang Yuan , Ma Chen Jing , He Fang Yan . Advances and Applications in Gene Silencing[J]. Journal of Kunming Medical University, 2018, 39(01): 131-135.

Advances and Applications in Gene Silencing

Funds:

基金: 国家自然科学基金资助项目 (81560664, 81660677);

  • Received Date: 2017-10-06
  • Gene silencing is a phenomenon in which the specific genes in organisms are not expressed or reduced for various reasons. It is an important mechanism to control gene expression by epigenetic control. At present, scientists intend to explore the treatment of difficult diseases through gene silencing technology, and the research has become a hot spot. With the rapid development of gene engineering, gene silencing technology has been replaced by new technologies. This paper aims to introduce the ribozyme technology, antisense oligonucleic acid technology, gene knockout, RNA interference technology and their applications in gene silencing technology.
  • loading
  • [1]
    [1]CECH T R, BASS B L.Biological catalysis by RNA[J].Annual Review of Biochemistry, 1986, 55 (1) :599.
    [2]
    [2]ALTMAN S.Enzymatic cleavage of RNA by RNA (Nobel Lecture) [J].Angewandte Chemie International Edition in English, 1990, 10 (4) :317-337.
    [3]
    [3]KILPATRICK M W, PHYLACTOU L A, GODFREY M, et al.Delivery of a hammerhead ribozyme specifically down-regulates the production of fibrillin-1 by cultured dermal fibroblasts[J].Human Molecular Genetics, 1996, 5 (12) :1939.
    [4]
    [4]LIEBER A, KAY M A.Adenovirus-mediated expression of ribozymes in mice[J].Journal of Virology, 1996, 70 (5) :3153.
    [5]
    [5]CORBEAU P, WONG-STAAL F.Anti-HIV Effects of HIV Vectors[J].Virology, 1998, 243 (2) :268.
    [6]
    [6]LIMA W F, WU H, CROOKE S T.Human RNases H[J].Methods in Enzymology, 2001, 341 (341) :430-440.
    [7]
    [7]PAN W H, CLAWSON G A.Identifying accessible sites in RNA:the first step in designing antisense reagents[J].Current Medicinal Chemistry, 2006, 13 (25) :3083-3103.
    [8]
    [8]VICKERS T A, KOOS, BENNETTCT, et al.Efficient reduction oftarget RNAs by small interfering RNA and RNase H-dependentantisense agents[J].J Biol Chem, 2003, 278 (9) :7108-7118.
    [9]
    [9]BALDOCCHIRA, GLYNNERJ, CHINK, et al.Design considerations for array CGH to oligonucleotide arrays[J].Cytometry A, 2005, 67 (2) :129-136.
    [10]
    [10]HAHNKEK, JACOBSENM, GRUETZKAUA, et al.Striptease on glass:validation of an improved stripping procedure for in situ microarrays[J].Journal of Biotechnology, 2007, 128 (1) :1-13.
    [11]
    [11]COBAUGH C W, CANNONE J J, DOSHI K J, et al.Evaluation of the suitability of free-energy minimization using nearest-neighbor energy parameters for RNA secondary structure prediction[J].Bmc Bioinformatics, 2004, 5 (1) :1-22.
    [12] 张剑, 杨晓梅, 高建刚.小鼠基因敲除的研究进展[J].山东大学学报 (理学版) , 2011, 46 (10) :183-196.
    [13]
    [13]JASON MORTON, M.WAYNE DAVIS, ERIK M.JORGENSEN, et al.Induction and repair of zinc-finger nuclease-targeted double-strand breaks in Caenorhabditis elegans somatic cells[J].Proc Natl Acad Sci USA, 2006, 103 (44) :16370-16375.
    [14]
    [14]PA GAMMAGE, J RORBACH, AI VINCENT, et al.Mitochondrially targeted ZFNs for selective degradation of pathogenic mitochondrial genomes bearing large-scale deletions or point mutations[J].Embo Molecular Medicine, 2014, 6 (4) :6863-6869.
    [15]
    [15]CL RAMIREZ, MT CERTO, C MUSSOLINO, et al.Engineered zinc finger nickases induce homology-directed repair with reduced mutagenic effects[J].Nucleic Acids Research, 2012, 40 (12) :5560-5568.
    [16]
    [16]PORTEUS M H, CARROLL D.Gene targeting using zinc finger nucleases[J].Nat Biotechnol, 2005, 23 (8) :967-973.
    [17]
    [17]GEURTS A M, COST G J, FREYVERT Y, et al.Knockout rats via embryo microinjection of zinc-finger nucleases[J].Science, 2009, 325 (5939) :433.
    [18]
    [18]CERMAK1 T, DOYLE E L, CHRISTIAN M, et al.Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting[J].Nucl Acids Res, 2011, 39 (12) :82.
    [19]
    [19]VM BEDELL, Y WANG, JM CAMPBELl, et al.In vivo genome editing using a high-efficiency TALEN system[J].Nature, 2012, 491 (7422) :114-118.
    [20]
    [20]DING Q, LEE Y K, SCHAEFER E K, et al.A TALEN genome-editing system for generating human stem cell-based disease models[J].Cell Stem Cell, 2012, 12 (2) :238-251.
    [21]
    [21]RODOLPHEBARRANGOU.RNA-mediated programmable DNA cleavage[J].Nat Biotechnol, 2012, 30 (9) :836-838.
    [22]
    [22]MUSSOLINO C, CATHOMEN T.RNA guides genome engineering[J].Nat Biotechnol, 2013, 31 (3) :208-209.
    [23]
    [23]CONG L, ANN RAN F, COX D, et al.Multiplex genome engineering using CRISPR/cas systems[J].Science, 2013, 339 (6121) :819-823.
    [24]张中华, 侯永泰.si RNA制备技术的研究进展[J].生命科学, 2004, 16 (4) :231-234.
    [25]
    [25]SOMAYEH S M, EHSAN A, VAHID S, et al.Potential si RNA molecules for nucleoprotein and M2/L overlapping region of respiratory syncytial virus:In silico design[J].Jundishapur Journal of Microbiology, 2016, 9 (4) :e34304.
    [26]
    [26]FAKHR E, ZARE F, TEIMOORITOOLABI L.Precise and efficient si RNA design:a key point in competent gene silencing[J].Cancer Gene Therapy, 2016, 23 (4) :73.
    [27]李泽豪, 任小元, 王世兵, 等.介导si RNA传递的非病毒载体及其研究进展[J].生命科学, 2014, 26 (4) :392-399.
    [28]
    [28]AMSALEM O, NASSAR T, BENHAMRON S, et al.Solid nano-in-nanoparticles for potential delivery of si RNA[J].Journal of Controlled Release, 2017, 10 (257) :144-155.
    [29]
    [29]DAHLMAN J E, CBARNES, OFKHAN, et al.In vivo endothelial si RNA delivery using polymeric nanoparticles with low molecular weight[J].Nature Nanotechnology, 2014, 9 (8) :648-655.
    [30]
    [30]HUSSER L, ALVES M P, RUGGLI N, et al.Identification of the role of RIG-I, MDA-5 and TLR3 in sensing RNA virusesin porcine epithelial cells using lentivirus-driven, RNA interference[J].Virus Res, 2011, 159 (1) :9-16.
    [31]
    [31]SUMIMOTO H, Y KAWAKAMI.Lentiviral vector-mediated RNAi and its use for cancer research[J].Future Oncology, 2016, 3 (6) :655-664.
    [32]
    [32]COHEN Z R, RAMISHETTI S, PESHES-YALOZ N, et al.Localized RNAi therapeutics of chemoresistant grade IV glioma using hyaluronangrafted lipid-based nanoparticles[J].Acs Nano, 2015, 9 (2) :1581-1591.
  • Relative Articles

    [1] Lan SHEN, Chaoming CHEN, Jianneng DAI, Lunqing PU, Tianrui WANG, Gang MA. The Application Effect and Influencing Factors of Rapid Rehabilitation Techniques Combined with Damage Control Surgical Techniques in Patients with Multiple Injuries. Journal of Kunming Medical University, 2024, 45(5): 103-108.  doi: 10.12259/j.issn.2095-610X.S20240516
    [2] Lizhu ZHAO, Ying DONG, Yue DENG, Lihua YANG. Correlation between Epithelial Cell Related Genes and Prognosis of Patients with Ovarian Cancer based on Single Cell Sequencing. Journal of Kunming Medical University, 2024, 45(4): 9-16.  doi: 10.12259/j.issn.2095-610X.S20240402
    [3] Guili LIANG, Canmei LI, Chengfeng XING, Yunlong DONG, Juan WANG, Zi LEI, Yinglei MIAO, Danfeng LAN. Changes of Intestinal Inflammatory Injury Induced by DSS in GC-C-/- Mice. Journal of Kunming Medical University, 2022, 43(7): 1-8.  doi: 10.12259/j.issn.2095-610X.S20220712
    [4] Huan LI, Qiu-yue XU, Yun-juan WANG, Yang SU, Rui-zhu TANG. The Rapid Detection of Nucleic Acid in SARS-CoV-2 by Reverse Transcription Loop Mediated Isothermal Amplification. Journal of Kunming Medical University, 2021, 42(9): 25-31.  doi: 10.12259/j.issn.2095-610X.S20210904
    [5] Liao Jing , Xu Chang Jun , Sun Chun Yi , Pan Jing , Zhou Hong Lin , Liu Yang . . Journal of Kunming Medical University, 2020, 41(09): 17-20.
    [6] Zhang Nan , Hu Xin Yu , Dong Xian Xiang , Duan Wei Gang , Yun Yu . . Journal of Kunming Medical University, 2019, 40(06): 129-134.
    [7] Liu Yang , Huang Ya Juan , Liao Jing , Sun Chun Yi , Di Shu Juan , Zhou Hong Lin . . Journal of Kunming Medical University, 2019, 40(12): 69-72.
    [8] Luo Yun , Luo Yu Hui , Liu Xiao Dong , Cui Qing Peng . . Journal of Kunming Medical University, 2018, 39(10): 18-23.
    [9] Liu Bo . Study of the Expression Differences of FHIT Protein in 90 Hepatocellular Tissues with Tissue Chip Method. Journal of Kunming Medical University,
    [10] Meng Jun . . Journal of Kunming Medical University,
    [11] Wu Jing Jing . . Journal of Kunming Medical University,
    [12] Wu Yan . . Journal of Kunming Medical University,
    [13] Zhou Ting Ting . . Journal of Kunming Medical University,
    [14] Chen Zhi Yu . . Journal of Kunming Medical University,
    [15] Chen Shao Chun . . Journal of Kunming Medical University, 2013, 34(07): 1-1.
    [16] Chen Da Lin . . Journal of Kunming Medical University,
    [17] Gu Zhen . . Journal of Kunming Medical University,
    [18] Li Shao Xiang . . Journal of Kunming Medical University,
    [19] Huang Yun Chao . . Journal of Kunming Medical University,
    [20] . Application of Patient Controlled-analgesia in Colonoscopy. Journal of Kunming Medical University,
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (3356) PDF downloads(1139) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return