An Analysis on HCV Treatment Efficacy among HIV/HCV Co-infected Patients

Gu Shan Qun; Li Zhong Xi; Bai Jing Song; Tian Bo; Yu Min; Liu Jun

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Article Navigation > Journal of Kunming Medical University > 2018 > 39(05): 120-123

Gu Shan Qun , Li Zhong Xi , Bai Jing Song , Tian Bo , Yu Min , Liu Jun . An Analysis on HCV Treatment Efficacy among HIV/HCV Co-infected Patients[J]. Journal of Kunming Medical University, 2018, 39(05): 120-123.

Citation:

Gu Shan Qun , Li Zhong Xi , Bai Jing Song , Tian Bo , Yu Min , Liu Jun . An Analysis on HCV Treatment Efficacy among HIV/HCV Co-infected Patients[J]. Journal of Kunming Medical University, 2018, 39(05): 120-123.

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An Analysis on HCV Treatment Efficacy among HIV/HCV Co-infected Patients

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基金：云南省教育厅科学研究基金资助项目 (2017ZDX011);

Received Date: 2018-02-03

Abstract

Abstract

Objective To observe the efficacy and safety of DAAs in treating HCV patients with HIV/HCV co-infection.Me thod 53 patients were divided into groups based on HCV genotype. Sofosbuvir + Ledipasvir regime were used for 1 b and 6 a subtypes; sofosbuvir + Daclatasvir regime were used for 3 a, 3 b and those cannot be typed; all the patients diagnosed with cirrhosis were also administrated with ribavirin. The course of treatment for all patients is 12 weeks.Re s ults All 53 patients completed HCV treatment, the overall SVR rate of DAAs treatment rate was 98.1% (52/53) , failure rate 1.9% (1/53) ; SVR rate of DAAs treatment among non-cirrhosis patients was 100% (41/41) ; SVR rate of DAAs treatment among cirrhosis patients was 91.7% (11/12) , failure rate8.3% (1/11) . After treatment, ALT and AST levels of DAAs treatment patients were decreased (P<0.05) , while CD4 level increased (P <0.05) . Main adverse effects are: 12 patients had gastrointestinal symptoms (22.6%) ; 6 had nausea, vomiting (11.3%) , 4 had diarrhea (7.6%) , 1 had mild rash (1.9%) , and 5 had elevated serum total bilirubin (9.4%) . Conclus ion The overall SVR rate among DAA treatment for HIV/HCV co-infected patients is high (98.1%) with broad indications. Even patients with cirrhosis are eligible. It yielded optimistic outcomes among different gene subtypes, and effectively improved liver function and CD4 level. With oral administration, short regime course, and mild adverse effects, patients can tolerate well, indicating its effectiveness and safety.
- HIV/HCV co-infection,
- DAAs,
- HCV,
- Treatment

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References(14)

References

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