An Analysis on HCV Treatment Efficacy among HIV/HCV Co-infected Patients

Gu Shan Qun; Li Zhong Xi; Bai Jing Song; Tian Bo; Yu Min; Liu Jun

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Article Navigation > Journal of Kunming Medical University > 2018 > 39(05): 120-123

Gu Shan Qun , Li Zhong Xi , Bai Jing Song , Tian Bo , Yu Min , Liu Jun . An Analysis on HCV Treatment Efficacy among HIV/HCV Co-infected Patients[J]. Journal of Kunming Medical University, 2018, 39(05): 120-123.

Citation:

Gu Shan Qun , Li Zhong Xi , Bai Jing Song , Tian Bo , Yu Min , Liu Jun . An Analysis on HCV Treatment Efficacy among HIV/HCV Co-infected Patients[J]. Journal of Kunming Medical University, 2018, 39(05): 120-123.

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An Analysis on HCV Treatment Efficacy among HIV/HCV Co-infected Patients

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基金：云南省教育厅科学研究基金资助项目 (2017ZDX011);

Received Date: 2018-02-03

Abstract

Abstract

Objective To observe the efficacy and safety of DAAs in treating HCV patients with HIV/HCV co-infection.Me thod 53 patients were divided into groups based on HCV genotype. Sofosbuvir + Ledipasvir regime were used for 1 b and 6 a subtypes; sofosbuvir + Daclatasvir regime were used for 3 a, 3 b and those cannot be typed; all the patients diagnosed with cirrhosis were also administrated with ribavirin. The course of treatment for all patients is 12 weeks.Re s ults All 53 patients completed HCV treatment, the overall SVR rate of DAAs treatment rate was 98.1% (52/53) , failure rate 1.9% (1/53) ; SVR rate of DAAs treatment among non-cirrhosis patients was 100% (41/41) ; SVR rate of DAAs treatment among cirrhosis patients was 91.7% (11/12) , failure rate8.3% (1/11) . After treatment, ALT and AST levels of DAAs treatment patients were decreased (P<0.05) , while CD4 level increased (P <0.05) . Main adverse effects are: 12 patients had gastrointestinal symptoms (22.6%) ; 6 had nausea, vomiting (11.3%) , 4 had diarrhea (7.6%) , 1 had mild rash (1.9%) , and 5 had elevated serum total bilirubin (9.4%) . Conclus ion The overall SVR rate among DAA treatment for HIV/HCV co-infected patients is high (98.1%) with broad indications. Even patients with cirrhosis are eligible. It yielded optimistic outcomes among different gene subtypes, and effectively improved liver function and CD4 level. With oral administration, short regime course, and mild adverse effects, patients can tolerate well, indicating its effectiveness and safety.
- HIV/HCV co-infection,
- DAAs,
- HCV,
- Treatment

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References(14)

References

[1]	[1] MARK S, SULKOWSKI MD, DAVID L, et nl.Hepatitis C in the HIV in fected person[J].Annals of Internal Medicine, 2003, 138 (3) :197-208.
[2]	[2]KANG L, HU J, XIA X S, et a1.HIV and HCV:from Co-infection to epidemiology, transmission, pathogenesis, and treatment[J].Virologica Sinica, 2007, 22 (6) :443-450.
[3]陈圆生, 李黎, 崔富强, 等.中国丙型肝炎血清流行病学研究[J].中华流行病学杂志, 2011, 32 (9) :888-891.
[4]	[4]IRENAM AIER, GEORGE YW.Hepatitis C and H IV Co-infection:A Review[J].World J Gastroentero, 2002, 8 (4) :577-579.
[5] 闰宇翔, 马子寅, 高艳清.HIV感染者中HBV/HCV混合感染情况及危险因素分析[A].首都医科大学公共卫生与家庭医学学院2010年第四届学术年会, 2010:62-68.
[6]阴宁, 梅珊, 张林琦, 等HIV感染者中HCV混合感染情况分析[J].中国抗感染化疗杂志, 2002, 2 (2) :67-69.
[7]马建新, 王江蓉, 沈银忠, 等.上海地区人类免疫缺陷病毒/艾滋病合并乙型丙型肝炎病毒感染的流行病学研究[J].微生物与感染, 2006, 04 (1) :207-210.
[8]刘俊, 陶剑, 田波, 等.昆明地区丙型肝炎病毒感染者与HIV合并丙型肝炎病毒感染者肝损伤研究.中国病毒病杂志, 2014, 4 (1) :26-28.
[9]	[9]EUROPEAN ASSOCIATION FOR STUDY OF LIVER.EASL recommendations on treatment of hepatitis C 2015[J].J Hepatol, 2015, 63 (1) :199-236.
[10]	[10]AASLD/IDSA HCV Guidance Panel.Hepatitis C guidance:AASLD-IDSA recommendations for testing, managing, and treating adults infected with hepatitis C virus[J].Hepatology, 2015, 62 (3) :932-954.
[11]	[11]HJERRILD S, DALGARD O, CHRISTENSEN P B, et al.Debilitating fatigue as a treatment indicatioin chronic hepatitis C[J].J Hepatol, 2015, 63 (6) :1533-1534.
[12]	[12] NAGGIE S, COOPER C, SAAG M, et al.Ledipasvir and Sofosbuvir for HCV in patients coinfected with HIV-1[J].N Engl J Med, 2015, 373 (8) :705-713.
[13]	[13] SULKOWSKI M S, ERON J J, WYLES D, et al.Ombitasvir, paritaprevir co-dosed with ritonavir, dasabuvir, and ribavirin for hepatitis C in patients co-infected with HIV-1:a randomized trial[J].JAMA, 2015, 313 (12) :1223-1231.
[14]周文劲, 刘俊, 白劲松, 等.HIV/HCV共感染者肝穿病理与临床指标[J].昆明医科大学学报, 2017, 38 (6) :136-139.

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