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Hu Kai , Dong Jie , Li Xiang , Li Dong , Zhao Yu Xiang , Zhu Yan Ren , Wang Jing , Liu Dan Dan , Zhou Lin Zong , Liang Lei Lei , Chen Jing Bo . A Study on the Synthesis of Veratraldehyde[J]. Journal of Kunming Medical University, 2018, 39(06): 31-34.
Citation: Hu Kai , Dong Jie , Li Xiang , Li Dong , Zhao Yu Xiang , Zhu Yan Ren , Wang Jing , Liu Dan Dan , Zhou Lin Zong , Liang Lei Lei , Chen Jing Bo . A Study on the Synthesis of Veratraldehyde[J]. Journal of Kunming Medical University, 2018, 39(06): 31-34.
shu

A Study on the Synthesis of Veratraldehyde

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基金： 国家自然科学基金资助项目 (21662041); 云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目[2017FE468 (-022) ]; 云南省天然药物药理重点实验室开放研究基金资助项目 (YZDY1501); 云南省教育厅科学研究基金资助项目 (2017zzx196);

  • Received Date: 2018-01-16
    Abstract
  • Objective Veratraldehyde is an important pharmaceutical intermediate and chemical raw material. Taking common synthetic methods of Veratraldehyde into consideration, the study is aimed to further investigate a more efficient synthetic route in order to provide a solid foundation for the application of Veratraldehyde.Me thods This article introduces an alternative method based on the Triton-B catalyzed olefin isomerization of methyl Eugenol followed by ozonation/reduction reaction.Re s ults In the experiment, the optimal conditions was selected by investigating the influence of reaction time, reaction temperature and catalyst dosage on the yield of Veratraldehyde. The total yield of this 2-step reactions was 64%. Conclus ion The above-mentioned synthesis method only requires raw materials that are easily acquired and its relative reaction conditions are mild, thus it will provide values in the industrial applications.
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