Clinical Effect of Autologous Peripheral Blood Stem Cell Transplantation Combined with Interventional Therapy in Treatment of Chronic Lower Limb Ischemia

Zhang Rui Peng; Wang Hui; Dai Yi; Zhang Hong; Li Wei; Wang Xiao Jun; Gao Zeng Zhan

Article Contents

Article Navigation > Journal of Kunming Medical University > 2018 > 39(07): 101-105

Zhang Rui Peng , Wang Hui , Dai Yi , Zhang Hong , Li Wei , Wang Xiao Jun , Gao Zeng Zhan . Clinical Effect of Autologous Peripheral Blood Stem Cell Transplantation Combined with Interventional Therapy in Treatment of Chronic Lower Limb Ischemia[J]. Journal of Kunming Medical University, 2018, 39(07): 101-105.

Citation:

Zhang Rui Peng , Wang Hui , Dai Yi , Zhang Hong , Li Wei , Wang Xiao Jun , Gao Zeng Zhan . Clinical Effect of Autologous Peripheral Blood Stem Cell Transplantation Combined with Interventional Therapy in Treatment of Chronic Lower Limb Ischemia[J]. Journal of Kunming Medical University, 2018, 39(07): 101-105.

Citation:

Zhang Rui Peng , Wang Hui , Dai Yi , Zhang Hong , Li Wei , Wang Xiao Jun , Gao Zeng Zhan . Clinical Effect of Autologous Peripheral Blood Stem Cell Transplantation Combined with Interventional Therapy in Treatment of Chronic Lower Limb Ischemia[J]. Journal of Kunming Medical University, 2018, 39(07): 101-105.

PDF( 219 KB)

Clinical Effect of Autologous Peripheral Blood Stem Cell Transplantation Combined with Interventional Therapy in Treatment of Chronic Lower Limb Ischemia

Funds:

基金：陕西省科技攻关资助项目 (2014K11-02-01-08);

Received Date: 2018-02-19

Abstract

Abstract

Objective To investigate the clinical effect of percutaneous transluminal angioplasty (PTA) combined with autologous peripheral blood stem cell transplantation (ABSCT) in treating chronic lower limb ischemia.Me thods A total of 48 patients with chronic lower limb ischemia were voluntarily allocated into 3 groups: 19 patients treated with ABSCT combined with PTA, named as combined treatment group; 10 patients treated with ABSCT alone, named as single ABSCT group; and 19 patients treated with PTA alone, named as single PTA group. Patients in 3 groups received conventional therapy. Limb pain, cold feeling, intermittent claudication, ankle brachial index (ABI) and the number of collateral vessel formation of patients in 3 groups were assessed before and after treatment. Comparison of clinical effects was performed in 3 groups.Re s ults Limb pain scores, cold feeling scores and intermittent claudication scores of the patients in 3 groups significantly decreased after treatment (P <0.05) . ABI score and the number of collateral vessel formation significantly increased (P<0.05) . The combined treatment group showed obvious improvement in all the measured assessmentindicators (P<0.05) . The total effective rate of combined treatment group was 89.5% while that in PTA group and ABSCT group were 78.9% and 60.0%, respectively. The total effective rate in combined treatment group was higher than that in both PTA group and ABSCT group (P <0.05) . Conclus ion When treating chronic lower limb ischemia, combination use of PTA and transplantation of ABSCT is safe and effective, and its treatment effect is superior to single PTA as well as single ABSCT.
- Chronic lower limb ischemia,
- ABSCT,
- Percutaneous transluminal angioplasty

FullText(HTML)

References(17)

References

[1]	[1]SAKAKI S, TAKAHASHI T, MATSUMOTO J, et al.Characteristics of physical activity in patients with critical limb ischemia[J].J Phys Ther Sci, 2016, 28 (12) :3454-3457.
[2]	[2]DOHMEN A, EDER S, EURINGER W, et al.Chronic critical limb ischemia[J].Dtsch Arztebl Int, 2012, 9 (6) :95-101.
[3]	[3]MOAZZAMI K, MAJDZADEH R, NEDJAT S.Local intramuscular transplantation of autologous mononuclear cells for critical lower limb ischaemia[J].Cochrane Database Syst Rev, 2014, 19 (12) :CD008347.
[4]舒畅, 何昊.下肢缺血性疾病的诊治进展[J].中国普通外科杂志, 2008, 17 (6) :523-527.
[5]	[5]ASAHARA T, MUROHARA T, SULLIVAN A, et al.Isolation of putative progenitor endothelial cells for angiogenesis[J].Science, 1997, 275 (5302) :964-967.
[6]	[6]HAMANO K, NISHIDA M, HIRATA K, et al.Local implantation of autologous bone marrow cells for therapeutic angiogenesis in patients with ischeminc heart disease;clinical trial and preliminary results[J].Jpn Circ J, 2001, 65 (9) :845-847.
[7]	[7]THEJ C, RAMADASSE B, WALVEKAR A, et al.Development of a surrogate potency assay to determine the angiogenic activity of Stempeucel (R) , a pooled, ex-vivo expanded, allogeneic human bone marrow mesenchymal stromal cell product[J].Stem Cell Res Ther, 2017, 8 (1) :47.
[8]李茂, 黄文.自体干细胞移植治疗严重下肢缺血[J].中国组织工程研究, 2013, 17 (49) :8602-8607.
[9]孙英伦, 杨镛, 马振桓, 等.自体外周血干细胞移植联合置管溶栓术治疗TAO患者血流重建并降低截肢平面[J].昆明医科大学学报, 2017, 38 (03) :59-63.
[10]叶丹, 闫波.自体骨髓干细胞移植治疗下肢缺血性疾病的临床研究[J].宁夏医科大学学报, 2016, 38 (12) :1436-1438.
[11]倪冷, 刘昌伟, 李拥军, 等.主髂动脉闭塞腔内治疗技巧及疗效[J].血管与腔内血管外科杂志, 2015, 1 (1) :32-35.
[12]赵杰, 杨立民, 张震, 等.介入溶栓与动脉取栓术治疗急性下肢动脉缺血疗效对比[J].昆明医科大学学报, 2015, 36 (11) :133-135.
[13]	[13]MWIPATAYI B P, HOCKINGS A, HOFMANN M, et al.Balloon angioplasty compared with stenting for treatment of femoropopliteal occlusive disease:A meta-analysis[J].J Vasc Surg, 2008, 47 (2) :461-469.
[14]	[14]XIAO L, HUANG DS, TONG J J, et al.Efficacy of endoluminal interventional therapy in diabetic peripheral arterial occlusive disease:a retrospective trial[J].Cardiovasc Diabetol, 2012, 11 (1) :1-17.
[15]	[15]PIAGGESI A, ABBRUZZESE L, MATTALIANO C, et al.Sulodexide as adjunctive therapy in diabetic foot patients with critical limb ischemia treated with percutaneous transluminal angioplasty[J].Int J Low Extrem Wounds, 2014, 13 (2) :103-109.
[16]	[16]LAWALL H, BRAMLAGE P, AMANN B.Treatment of peripheral arterial disease using stem and progenitor cell therapy[J].J Vasc Surg, 2011, 53 (2) :445-453.
[17]	[17]DASH SN, DASH NR, GURU B, et al.Towards reaching the target:clinical application of mesenchymal stem cells for diabetic foot ulcers[J].Rejuvenation Res, 2014, 17 (1) :40-53.

Relative Articles(20)

Relative Articles

[1]	Xi GUO, Xiaoqing TANG, Jie WANG, Yan WAN, Bin XU, Yu LUO. Effect of Early Interventional Palliative Treatment on Pain and Anxiety in Patients with Hepatitis-Related Liver Cancer. Journal of Kunming Medical University, 2022, 43(8): 93-99. doi: 10.12259/j.issn.2095-610X.S20220813
[2]	Wei YUAN, Mingyao MENG, Xinxin LI, Jingjing XIONG, Meng LI, Jia CAO, Mei LIU, Zongliu HOU, Yongkun HUANG. Effects of Dose-response and Time-dependent of Endotoxin on Proliferation of Human Umbilical Cord Mesenchymal Stem Cells. Journal of Kunming Medical University, 2022, 43(9): 7-12. doi: 10.12259/j.issn.2095-610X.S20220928
[3]	Guo-ji CHANG, Ying HUANG, Yan-ling ZHANG, Hua HE, Jun XU, Yang LI. Comparison of the Efficacy of Ommaya Reservoir and Lumbar Cistern Intervention of Tuberculous Meningoencephalitis Complicated with Hydrocephalus. Journal of Kunming Medical University, 2021, 42(4): 122-127. doi: 10.12259/j.issn.2095-610X.S20210423
[4]	Liu Xin Zhi , Zhao Heng , Luo Yi , Xu Min Hua , Min Xiao Li . . Journal of Kunming Medical University, 2018, 39(10): 121-125.
[5]	Hou Xiao Mei , Qi Wen Jin . Nursing Summary of Interventional Therapy in Induced Abortion after Placental Hemorrhage in Mid-term of Pregnancy. Journal of Kunming Medical University, 2017, 38(01): 142-144.
[6]	Huang Song Xia . The Effect of Evidence-based Care on the Complication Rate and Comfort in Patients with Coronary Heart Disease after Intervention Therapy. Journal of Kunming Medical University,
[7]	Tong Yu Yun . . Journal of Kunming Medical University,
[8]	Wang Shi Ping . . Journal of Kunming Medical University,
[9]	Zhang Ti Ling . . Journal of Kunming Medical University,
[10]	Lai 碁. . Journal of Kunming Medical University,
[11]	Wang Shi Ping . . Journal of Kunming Medical University,
[12]	Dai Hai Long . . Journal of Kunming Medical University,
[13]	Lu Yi Bing . . Journal of Kunming Medical University,
[14]	Luo Jing . . Journal of Kunming Medical University,
[15]	Liu Hai Li . . Journal of Kunming Medical University,
[16]	Wen Jiao . . Journal of Kunming Medical University,
[17]	Huang Ming . . Journal of Kunming Medical University,
[18]	Guo Xi . . Journal of Kunming Medical University,
[19]	Wang Shi Ping . Experiences in the Treatment of Chronic Empyema with Pleural Decortication. Journal of Kunming Medical University,
[20]	Wang Qi Xian . . Journal of Kunming Medical University,