Effect of Malnutrition and Micro-inflammatory State on Cardiovascular Calcification in Patients with Peritoneal Dialysis

Hu Shao Lan; Yang Min; Bai Yi Hua; Zheng Shuai; Xiao Ming Xian

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Hu Shao Lan , Yang Min , Bai Yi Hua , Zheng Shuai , Xiao Ming Xian . Effect of Malnutrition and Micro-inflammatory State on Cardiovascular Calcification in Patients with Peritoneal Dialysis[J]. Journal of Kunming Medical University, 2018, 39(07): 47-51.

Citation:

Hu Shao Lan , Yang Min , Bai Yi Hua , Zheng Shuai , Xiao Ming Xian . Effect of Malnutrition and Micro-inflammatory State on Cardiovascular Calcification in Patients with Peritoneal Dialysis[J]. Journal of Kunming Medical University, 2018, 39(07): 47-51.

Citation:

Hu Shao Lan , Yang Min , Bai Yi Hua , Zheng Shuai , Xiao Ming Xian . Effect of Malnutrition and Micro-inflammatory State on Cardiovascular Calcification in Patients with Peritoneal Dialysis[J]. Journal of Kunming Medical University, 2018, 39(07): 47-51.

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Effect of Malnutrition and Micro-inflammatory State on Cardiovascular Calcification in Patients with Peritoneal Dialysis

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基金：云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目 (2015FB054);

Received Date: 2018-03-14

Abstract

Abstract

Objective To analyze the correlation between cardiovascular calcification and malnutrition and micro-inflammatory state, and to explore the related risk factors of cardiovascular calcification in patients with maintenance peritoneal dialysis.Methods From January 2016 to December 2017, 81 patients undergoing continuous ambulatory peritoneal dialysis (CAPD) at the Second Affiliated Hospital of Kunming Medical University were enrolled in the study. The related laboratory tests and body measurements were performed in the81 patients. Cardiac Valve Calcification (CVC) was estimated by transthoracic echocardiography and abdomen lateral radiographs to understand the status of abdominal aortic calcification (AAC) . Nutritional status was assessed by modified quantitative subjective global assessment table (MQSGA) , which was divided into normal nutrition (<10 points) , mild to moderate malnutrition (11-20 points) , and severe malnutrition (21-35 points) group. Results Twenty-four patients (29.6%) in the normal group, forty-one patients (50.6%) in the mild to moderate group, and sixteen patients (19.8%) in the severe group were found.The incidence of valve calcification, abdominal aorta calcification and cardiovascular calcification were 45.7%, 24.7%, and 55.6% respectively. Significant difference was found in malnutrition and micro-inflammatory state between the two groups with and without valve calcification. Age (P = 0.006) , dialysis age (P = 0.048) , prealbumin (P = 0.015) , phosphorus (P = 0.007) , calcium-phosphorus product (P = 0.013) and hs-CRP (P = 0.004) were significantly different between valvular and non-valvular calcification group. Conclusion Malnutrition and micro-inflammatory states can be found in most peritoneal dialysis patients.The more severe the malnutrition and micro-inflammatory state are, the higher the incidence of cardiovascular calcification is.Advanced age, years of dialysis, low prealbumin, high phosphorus, high calcium-phosphorus product, and elevated hs-CRP can be the independent risk factor of cardiovascular calcification.
- Malnutrition,
- Micro-inflammation,
- Cardiovascular calcification,
- Peritoneal dialysis

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References(19)

References

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