Application of T-lymphocyte Subsets for Non-viral Liver Disease

Lv Song Qin; Huang Shan; Li Xiao Fei; Shi Jin Li; Li Guang Min; Duan Hong Fen

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Lv Song Qin , Huang Shan , Li Xiao Fei , Shi Jin Li , Li Guang Min , Duan Hong Fen . Application of T-lymphocyte Subsets for Non-viral Liver Disease[J]. Journal of Kunming Medical University, 2019, 40(03): 107-111.

Citation:

Lv Song Qin , Huang Shan , Li Xiao Fei , Shi Jin Li , Li Guang Min , Duan Hong Fen . Application of T-lymphocyte Subsets for Non-viral Liver Disease[J]. Journal of Kunming Medical University, 2019, 40(03): 107-111.

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Application of T-lymphocyte Subsets for Non-viral Liver Disease

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基金：昆明市科技局科研计划项目 (2016-2-S-06467);

Received Date: 2018-10-19

Abstract

Abstract

Objective To study the application value of T-lymphocyte subsets for non-viral liver disease Methods180 cases of non-viral liver disease patients in The third people's Hospital of Kunming from June 1, 2017 to May 30, 2018 were collected.The peripheral blood of patients were tested and analyzed by BECKMAN Navios Flow Cytometer, and compared with of the reference ranges of peripheral blood T-lymphocyte subsets among healthy adults of Kunming.ROC analysis was used to test each index.Results Compared with the control group, CD3+, CD3+CD8+cells absolute number and the ratio of CD3+CD8+/lymphocytes with alcoholic cirrhosis group was significantly lower than the control group (P<0.05) , the ratio of CD4+/CD8+was significantly higher (P<0.001) .The ratio of CD3+CD4+/lymphocytes and CD4+/CD8+with primary biliary cirr Ilosis group was significantly higher than the control group (P<0.001) .The AUC value of CD3+, CD3+CD8+, CD3+CD8+/lymphocytes, CD4+/CD8+with alcoholic cirrhosis group was 0.80, 0.82, 0.66, 0.74.The AUC value of CD3+CD4+/lymphocytes and CD4+/CD8+with primary biliary cirr Ilosis group had a greater value, was 0.80, 0.81.ConclusionT lymphocyte subset can be the assistant diagnostic index of alcoholic cirrhosis and primary biliary cirrhosis.
- T lymphocyte subset,
- Non-viral liver disease,
- Flow cytometry

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References(21)

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