Experiment Research of Degradable Magnesium Alloy AZ31 Tissue Clips Implanted to New Zealand Rabbits

Kong Xiang Dong; Xiong Xi Lu; Yuan Shao Feng; Pan Liang Ming; Ji Qin Long; Wang Xi

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Kong Xiang Dong , Xiong Xi Lu , Yuan Shao Feng , Pan Liang Ming , Ji Qin Long , Wang Xi . Experiment Research of Degradable Magnesium Alloy AZ31 Tissue Clips Implanted to New Zealand Rabbits[J]. Journal of Kunming Medical University, 2019, 40(03): 18-23.

Citation:

Kong Xiang Dong , Xiong Xi Lu , Yuan Shao Feng , Pan Liang Ming , Ji Qin Long , Wang Xi . Experiment Research of Degradable Magnesium Alloy AZ31 Tissue Clips Implanted to New Zealand Rabbits[J]. Journal of Kunming Medical University, 2019, 40(03): 18-23.

Citation:

Kong Xiang Dong , Xiong Xi Lu , Yuan Shao Feng , Pan Liang Ming , Ji Qin Long , Wang Xi . Experiment Research of Degradable Magnesium Alloy AZ31 Tissue Clips Implanted to New Zealand Rabbits[J]. Journal of Kunming Medical University, 2019, 40(03): 18-23.

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Experiment Research of Degradable Magnesium Alloy AZ31 Tissue Clips Implanted to New Zealand Rabbits

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基金：上海市金山区卫生系统“优秀青年人才“培养计划 (JSYQ201620); 上海市金山区医疗卫生学科建设基金资助项目 (JSZK2015B06);

Received Date: 2018-10-20

Abstract

Abstract

Objective To study the degradation of magnesium alloy AZ31 tissue clips and its effect on the function of animal organs. Methods New Zealand rabbits were used to build the magnesium alloy AZ31 implanted model. Regular observation of wound healing and general condition was firstly carried out. And then blood was collected to detect the blood routine, coagulation function, liver and kidney functions and the content of calcium, phosphate and magnesium according to the clinical testing methods. The heart, liver, spleen, lung, kidney samples were collected to examine whether pathological changes contained in them. X-ray was carried out to observe the degradation of tissue clips in New Zealand rabbits. Results The biological safety of AZ31 material was confirmed by safety research in vivo. This material had no effect on the results of blood routine index, coagulation function, hepatic function, and renal function cardiac function. No accumulation of harmful substances was observed under the light microscope after HE staining for tissue sections of important internal organs. X-rays showed that there was no significant gas accumulated around the clips and tissue clips degrade slowly in New Zealand rabbitss.Conlusion Magnesium alloy AZ31 is a relatively safe degradable magnesium alloy material, which can be used to make tissue clips, and has a certain clinical application prospect.
- Magnesium alloy,
- Tissue clip,
- Animal experiments

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References(19)

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