Study on ANP Level in Peripheral Blood of Patients with Hypertension in Yunnan

Xiaoli ZHAO; Yongxin MA; Jing QIAN; Dan ZHU; Rufeng YANG; Min TIAN; Yuexuan XU; Chunli YANG; Shurong TANG; Haisheng LI

doi:10.12259/j.issn.2095-610X.S20221029

Volume 43 Issue 10

Oct. 2022

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Article Navigation > Journal of Kunming Medical University > 2022 > 43(10): 62-65

Xiaoli ZHAO, Yongxin MA, Jing QIAN, Dan ZHU, Rufeng YANG, Min TIAN, Yuexuan XU, Chunli YANG, Shurong TANG, Haisheng LI. Study on ANP Level in Peripheral Blood of Patients with Hypertension in Yunnan[J]. Journal of Kunming Medical University, 2022, 43(10): 62-65. doi: 10.12259/j.issn.2095-610X.S20221029

Citation:

Xiaoli ZHAO, Yongxin MA, Jing QIAN, Dan ZHU, Rufeng YANG, Min TIAN, Yuexuan XU, Chunli YANG, Shurong TANG, Haisheng LI. Study on ANP Level in Peripheral Blood of Patients with Hypertension in Yunnan[J]. Journal of Kunming Medical University, 2022, 43(10): 62-65. doi: 10.12259/j.issn.2095-610X.S20221029

Citation:

Xiaoli ZHAO, Yongxin MA, Jing QIAN, Dan ZHU, Rufeng YANG, Min TIAN, Yuexuan XU, Chunli YANG, Shurong TANG, Haisheng LI. Study on ANP Level in Peripheral Blood of Patients with Hypertension in Yunnan[J]. Journal of Kunming Medical University, 2022, 43(10): 62-65. doi: 10.12259/j.issn.2095-610X.S20221029

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Study on ANP Level in Peripheral Blood of Patients with Hypertension in Yunnan

doi: 10.12259/j.issn.2095-610X.S20221029

Clinical Laboratory，The First People’s Hospital of Kunming，The Affiliated Ganmei Hospital of Kunming Medical University，Kunming Yunnan 650011，China

Received Date: 2022-06-11
Publish Date: 2022-10-25

Abstract

Abstract

Objective To observe the changes of ANP levels in the peripheral blood of patients with essential hypertension in Yunnan, and to explore the relationship between it and the pathogenesis of essential hypertension. Methods We selected 44 patients with essential hypertension diagnosed in the cardiology department of our hospital from June to September 2019 and set them as the case group. We also selected 44 healthy patients from the physical examination center of our hospital as the healthy control group. The ELISA method was used to detect the ANP level in the peripheral blood of the subjects. Results The level of ANP in the peripheral blood of patients with essential hypertension was significantly lower than that of normal people（P < 0.05）; the occurrence of hypertension was used as the dependent variable and the serum ANP was used as the independent variable for logistic regression analysis. The results showed that ANP The partial regression coefficient with hypertension was 0.071, and the P value was 0.002（ P < 0.05）. It was statistically significant; the person correlation analysis was used to analyze ANP and SBP/DBP, and the results showed that the correlation coefficient between ANP and SBP was -0.374. The P value is 0.000（ P < 0.05）; the correlation coefficient between ANP and DBP is -0.331, and the P value is 0.002（ P < 0.05）, both of which are statistically significant, but compared to DBP, the correlation between ANP and SBP is more significant. Conclusions The low concentration of ANP in peripheral blood is closely related to the increase of blood pressure; NPR-C ligand ANP is involved in the pathogenesis of essential hypertension; ANP affects the changes in the level of SBP/DBP, and has a more significant impact on SBP.
- Primary hypertension,
- NPR-C,
- ANP

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References(12)

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