Effects of Ranibizumab and Odix on the Microvascular Structure of the Macular Region
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摘要:
目的 探讨雷珠单抗和傲迪适对视网膜静脉阻塞-黄斑水肿（RVO-ME）患者黄斑区微血管结构的影响。 方法 将眼科收治并确诊的RVO-ME所有患者纳入筛选范围，选取101例患者作为研究对象，纳入时间2020年1月至2021年12月，按治疗方法差异将其分成A、B组（观察组、对照组），各51例、50例，A组给予玻璃体腔注射雷珠单抗治疗，B组给予玻璃体腔注射傲迪适治疗，将2组年龄、性别及治疗前后的最佳矫正视力（BCVA）、黄斑中心凹厚度（CMT）及视网膜浅层毛细血管层（SCP）、深层毛细血管层血流密度（DCP）及其他治疗有效率等指标纳入SPSS21.0软件处理，比较其治疗治疗差异。 结果 （1）A、B组治疗前BCVA、CMT、SCP、DCP相比差异无统计学意义（P > 0.05），随着治疗时间的后延，A、B组的BCVA、CMT、SCP、DCP均显著改善，且B组较A组更优，差异有统计学意义（P < 0.05）；（2）A组治疗后3、6个月时治疗总有效率各94.12%、98.04%，B组各84.00%、88.00%，且B组较A组更优，差异有统计学意义（P < 0.05）。 结论 傲迪适治疗能有效的改善RVO-ME患者的黄斑区微血管结构。 Abstract:Objective To investigate the effect of ranibizumab and odix on the microvascular structure of the macular region in patients with retinal vein occlusion-macular edema （RVO-ME）. Methods All patients with RVO-ME admitted and diagnosed in the ophthalmology department of our hospital were included in the screening scope, and 101 of them were selected as the research subjects. The inclusion time was from January 2020 to December 2021, and they were divided into the observation group and the control group according to the differences in treatment methods, with 51 cases and 50 cases in each group. The observation group was given intravitreal injection of ranibizumab, and the control group was given intravitreal injection of AODEX. The age, gender, best corrected visual acuity （BCVA）, macular fovea thickness （CMT）, shallow retinal capillary layer （SCP）, deep capillary layer blood flow density （DCP） and other effective rates of the two groups before and after the treatment were included in spss21.0 software to compare the treatment differences. Results （1） There was no significant difference in BCVA, CMT, SCP, and DCP between the two groups before the treatment （P > 0.05）. With the delay of treatment time, BCVA, CMT, SCP and DCP of the two groups were significantly improved ,the control group was better than the observation group and the difference was statistically significant （P < 0.05） and （2） The total effective rates of the observation group were 94.12% and 98.04% at 3 and 6 months after the treatment while the total effective rates of the control group were 84.00% and 88.00%, showing that the control group was better than the observation group and the difference was statistically significant （P < 0.05）. Conclusion Autodix treatment can effectively improve the macular microvascular structure in RVO-ME patients. -
Key words:
- Ranibizumab /
- AODIX /
- Retinal vein occlusion /
- Macular edema /
- Microvascular structure of macular region
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图 1 黄斑区视网膜内病灶呈高反射
Figure 1. Intraretinal lesions in the macular region are highly reflective
图 2 治疗后左眼黄斑区见脉络膜新生血管信号（圆圈）
A：治疗前脉络膜新生血管呈现高反射物质信号；B：治疗中脉络膜新生血管信号情况；C：治疗后脉络膜新生血管信号减弱，高反射物质信号转为低平。
Figure 2. Choroidal neovascularization signal （circle） in the macular area of the left eye after treatment
表 1 A、B组常规资料统计情况表[
$\bar x \pm s $ /n（%）]Table 1. Statistics of routine data of groups A and B [
$\bar x \pm s $ /n]组别 年龄区间（岁） 平均年龄（岁） 性别 患眼眼数（n） 男 女 A组 44～70 60.52 ± 5.78 31 20 51 B组 45～70 60.23 ± 5.56 29 21 50 χ2/t 0.257 0.081 P < 0.001* < 0.001* *P < 0.05。 
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表 2 A、B组治疗前后的BCVA差异比较[（
$ \bar x \pm s $ ），μm]Table 2. Comparison of BCVA differences between groups A and B before and after treatment [（
$ \bar x \pm s $ ），μm]组别 n 治疗前 治疗后 1 d 3个月 6个月 A组 51 1.09 ± 0.43 0.76 ± 0.47 0.67 ± 0.24* 0.58 ± 0.13* B组 50 1.12 ± 0.41 0.82 ± 0.35 0.51 ± 0.19 0.41 ± 0.21 t 0.359 −0.729 3.719 4.902 P 0.720 0.468 < 0.001* < 0.001* *P < 0.05。
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表 3 A、B组治疗前后的CMT差异比较[（
$ \bar x \pm s $ ），μm]Table 3. Comparison of CMT differences between groups A and B before and after treatment [（
$ \bar x \pm s $ ），μm]组别 n 治疗前 治疗后 1 d 3个月 6个月 A组 51 470.35 ± 113.54 425.76 ± 100.47 376.67 ± 103.24* 342.14 ± 112.31* B组 50 472.32 ± 101.37 400.82 ± 102.36 320.51 ± 101.19 297.14 ± 106.52 t 0.092 1.236 2.861 2.078 P 0.927 0.219 0.007* 0.038* *P < 0.05。
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表 4 A、B组治疗前后的SCP差异比较[（
$ \bar x \pm s $ ），%]Table 4. Comparison of SCP differences between groups A and B before and after treatment[（
$ \bar x \pm s $ ），%]组别 n 治疗前 治疗后 1 d 3个月 6个月 A组 51 51.09 ± 11.43 43.76 ± 8.47 46.67 ± 6.24* 54.58 ± 4.13* B组 50 40.12 ± 10.41 45.82 ± 8.35 52.51 ± 5.86 61.41 ± 4.26 t 0.014 −1.231 −4.849 −8.298 P 0.989 0.221 < 0.001* < 0.001* *P < 0.05。
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表 5 A、B组治疗前后的DCP差异比较[（
$ \bar x \pm s $ ），%]Table 5. Comparison of DCP differences between groups A and B before and after treatment [（
$ \bar x \pm s $ ），%]组别 n 治疗前 治疗后 1 d 3个月 6个月 A组 51 41.09 ± 8.47 43.76 ± 6.47* 48.67 ± 7.24* 53.58 ± 8.13* B组 50 40.12 ± 8.43 46.82 ± 7.35 54.51 ± 7.19 62.34 ± 8.21 t 0.577 −2.219 −4.067 −5.387 P 0.565 0.029* < 0.001* < 0.001* *P < 0.05。
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表 6 A、B组治疗前后的SRF差异比较[（
$ \bar x \pm s $ ），μm]Table 6. Comparison of SRF differences between groups A and B before and after treatment[（
$ \bar x \pm s $ ），μm]组别 n 治疗前 治疗后 1 d 3个月 6个月 A组 51 211.09 ± 38.46 188.46 ± 41.35* 148.64 ± 31.65* 43.64 ± 8.48* B组 50 210.46 ± 35.33 171.82 ± 37.75 124.51 ± 27.19 28.53 ± 6.73 t 0.085 2.112 4.113 9.929 P 0.576 0.037 < 0.001* < 0.001* *P < 0.05。
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