留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

头颈4D- CTA 结合SDF-1a/CXCR4 信号通路评估颅内后交通动脉瘤破裂风险的价值

徐艺铭 钟剑锋 李斌 周欣颜 朱红丽 梁靖 廖承德

徐艺铭, 钟剑锋, 李斌, 周欣颜, 朱红丽, 梁靖, 廖承德. 头颈4D- CTA 结合SDF-1a/CXCR4 信号通路评估颅内后交通动脉瘤破裂风险的价值[J]. 昆明医科大学学报, 2024, 45(3): 59-64. doi: 10.12259/j.issn.2095-610X.S20240309
引用本文: 徐艺铭, 钟剑锋, 李斌, 周欣颜, 朱红丽, 梁靖, 廖承德. 头颈4D- CTA 结合SDF-1a/CXCR4 信号通路评估颅内后交通动脉瘤破裂风险的价值[J]. 昆明医科大学学报, 2024, 45(3): 59-64. doi: 10.12259/j.issn.2095-610X.S20240309
Yiming XU, Jianfeng ZHONG, Bin LI, Xinyan ZHOU, Hongli ZHU, Jing LIANG, Chengde LIAO. Value of Head and Neck 4D-CTA Combined with SDF-1a/CXCR4 Signaling Pathway in Assessing the Risk of Ruptured Intracranial Posterior Communicating Aneurysms[J]. Journal of Kunming Medical University, 2024, 45(3): 59-64. doi: 10.12259/j.issn.2095-610X.S20240309
Citation: Yiming XU, Jianfeng ZHONG, Bin LI, Xinyan ZHOU, Hongli ZHU, Jing LIANG, Chengde LIAO. Value of Head and Neck 4D-CTA Combined with SDF-1a/CXCR4 Signaling Pathway in Assessing the Risk of Ruptured Intracranial Posterior Communicating Aneurysms[J]. Journal of Kunming Medical University, 2024, 45(3): 59-64. doi: 10.12259/j.issn.2095-610X.S20240309

头颈4D- CTA 结合SDF-1a/CXCR4 信号通路评估颅内后交通动脉瘤破裂风险的价值

doi: 10.12259/j.issn.2095-610X.S20240309
基金项目: 云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目(202401AY0700-358);云南省教育厅科学研究基金资助项目(2024J0399);昆明市心血管影像技术中心(2023-SW(技术)-04);昆明市“十百千”工程(2021-SW(后背)-09)。
详细信息
    作者简介:

    徐艺铭(1983~),男,辽宁大连人,医学硕士,副主任医师,主要从事头颈血管研究工作

    通讯作者:

    梁靖,E-mail:845628673@qq.com

    廖承德,E-mail:1114052293@qq.com

  • 中图分类号: R445.3

Value of Head and Neck 4D-CTA Combined with SDF-1a/CXCR4 Signaling Pathway in Assessing the Risk of Ruptured Intracranial Posterior Communicating Aneurysms

  • 摘要:   目的  探讨利用4D-CTA结合SDF-1a/CXCR4 信号通路评估颅内后交通动脉瘤破裂风险的价值。  方法  将 50 名未破裂颅内前交通动脉瘤患者和 50 名破裂颅内前交通动脉瘤患者分为未破裂组 1 和破裂组 1。所有患者均接受 4D-CTA 检查并检测血清SDF-1a水平。非破裂组 1 接受了 12 个月的随访后把后脉瘤破裂的患者被纳入破裂组 2,动脉瘤未破裂的患者被纳入非破裂组 2。  结果  诊断颅内后交通动脉瘤破裂的 Wn、AR、L、SR、SDF-1a 及其组合的 AUC 值均大于 0.70。破裂组 2 Wn、AR、L、SR和SDF-1a及其组合预测颅内后交通动脉瘤破裂的AUC值均大于0.70。  结论  4D-CTA 联合SDF-1a能有效区分破裂的颅内后交通动脉瘤并预测破裂风险。
  • 图  1  AR、SR 及 VOR 测量简图

    Figure  1.  AR, SR,and VOR measurement diagrams

    图  2  4D-CTA 搏动点示意图

    Figure  2.  Schematic diagram of 4D-CTA pulsatile points

    图  3  AR、SR 及 VOR 数值 测量图示并动脉瘤基底部见异常搏动点(黄箭头所示)

    Figure  3.  Diagram of 4D measurement of AR,SR,and VOR values(shown by yellow arrow)

    图  4  4D-CTA成像 后交通动脉异常搏动点(绿箭头)

    Figure  4.  Abnormal pulse points of Traffic artery after 4D-CTA (green arrow)

    图  5  4D-CTA联合SDF-1对颅内后交通动脉瘤破裂的诊断价值

    Figure  5.  Diagnostic value of 4D-CTA combined with SDF-1 in the rupture of intracranial posterior communicating aneurysms

    图  6  4D-CTA联合SDF-1对颅内后交通动脉瘤破裂的预测价值

    Figure  6.  Predictive value of 4D-CTA combined with SDF-1 for ruptured intracranial aneurysms

    表  1  破裂组1和非破裂组1 SDF-1对比[μg/L,($\bar x \pm s $)]

    Table  1.   Comparison of SDF-1 between unruptured group 1 and ruptured group 1 [μg/L,($\bar x \pm s $)]

    组别SDF-1
    破裂组 1 (n=50) 135.03±11.01
    非破裂 1 (n=50) 149.48±13.22
    T 5.900
    P <0.001*
      *P<0.05。
    下载: 导出CSV

    表  2  4D-CTA联合SDF-1对颅内后交通动脉瘤破裂的诊断价值

    Table  2.   Diagnostic value of 4D-CTA combined with SDF-1 in the rupture of intracranial posterior communicating aneurysms.

    因素AUC临界值95%CIP特性异敏感性
    Wn0.8442.9900.765~0.923<0.001*0.7600.860
    AR0.8881.1150.818~0.958<0.001*0.8400.900
    L0.8344.5850.758~0.909<0.001*0.6600.820
    SR0.7711.2550.679~0.863<0.001*0.6800.740
    SDF-10.800141.1550.712~0.887<0.001*0.7600.760
    Combination0.9760.953~0.999<0.001*0.8800.960
      *P<0.05。
    下载: 导出CSV

    表  3  破裂组2和非破裂组2 SDF-1对比[μg/L,($\bar x \pm s $)]

    Table  3.   Comparison of SDF-1 between unruptured group 2 and ruptured group 2 [μg/L,($\bar x \pm s $)]

    组别SDF-1
    破裂组2 (n=19) 142.38±11.22
    非破裂2 (n=31) 128.13±10.22
    t 4.660
    P <0.001*
      *P<0.05。
    下载: 导出CSV

    表  4  联合SDF-1对颅内后交通动脉瘤破裂的预测价值

    Table  4.   Predictive value of combined SDF-1 for rupture of intracranial posterior communicating aneurysms

    因素AUC临界值95%CIP特性异敏感性
    Wn0.9262.7100.856~0.996<0.001*0.8710.842
    AR0.7051.0650.546~0.8630.0160.7100.632
    L0.7444.2150.579~0.9100.0040.7420.737
    SR0.7921.1150.652~0.9320.0010.6450.789
    SDF-10.847133.5100.742~0.952<0.001*0.7100.789
    Combination0.9730.928~1.000<0.001*0.9030.947
      *P<0.05。
    下载: 导出CSV
  • [1] Adeeb N,Griessenauer C J,Dmytriw A A,et al. Risk of branch occlusion and ischemic complications with the pipeline embolization device in the treatment of posterior circulation aneurysms[J]. AJNR Am J Neuroradiol,2018,39(7):1303-1309. doi: 10.3174/ajnr.A5696
    [2] Cao R,Jiang Y,Li L,et al. Venous collaterals in acute ischemic stroke patients after endovascular treatments: a novel scoring system using 4D computed tomography angiography[J]. Quant Imaging Med Surg,2022,12(11):5030-5043. doi: 10.21037/qims-22-245
    [3] Liu S, Wang Y N, Ma B, et al . Gingipain-responsive thermosensitive hydrogel loaded with SDF-1 facilitates in situ periodontal tissue regeneration[J]. ACS Appl Mater Interfaces, 2021, 13(31): 368 80-36893.
    [4] Shi J,Yang Y,Yin N,et al. Engineering CXCL12 biomimetic decoy-integrated versatile immunosuppressive nanoparticle for ischemic stroke therapy with management of overactivated brain Immune microenvironment[J]. Small Methods,2022,6(1):e2101158. doi: 10.1002/smtd.202101158
    [5] 徐鹏,陈英,施小燕,等. 3D-CTA 对颅内后循环出血性动脉瘤早期诊断的价值[J]. 中华急诊医学杂志,2020,29(1):127-131.
    [6] Hallikainen J,Keränen S,Savolainen J,et al. Role of oral pathogens in the pathogenesis of intracranial aneurysm: review of existing evidence and potential mechanisms[J]. Neurosurg Rev,2021,44(1):239-247. doi: 10.1007/s10143-020-01253-y
    [7] Sahnoun M, Soize S, Manceau P F, et al Intracranial aneurysm treatment with WEB and adjunctive stent: preliminary evaluation in a single-center series[J]. J Neurointerv Surg 2022 , 14(2): 164-168.
    [8] Isoda R,Kanaoka Y,Watanabe T,et al. Total debranching plus antegrade thoracic endovascular aortic repair without side clamping in a patient with arch aneurysm and ascending aorta calcification[J]. Ann Vasc Dis,2021,14(2):181-184. doi: 10.3400/avd.cr.21-00035
    [9] Saiga A,Koizumi J,Osumi K,et al. Celiac artery dissection and retroperitoneal hemorrhage in median arcuate ligament syndrome treated with a stent and transcatheter arterial embolization: Preprocedural 4-dimensional computed tomography angiography assessment[J]. Vasc Endovascular Surg,2022,56(1):75-79. doi: 10.1177/15385744211028738
    [10] Zhang J,Li X,Zhao B,et al. Irregular pulsation of aneurysmal wall is associated with symptomatic and ruptured intracranial aneurysms[J]. J Neurointerv Surg,2023,15(1):91-96. doi: 10.1136/neurintsurg-2021-018381
    [11] De Paepe M E,Wong T,Chu S,et al. Stromal cell-derived factor-1 (SDF-1) expression in very preterm human lungs: Potential relevance for stem cell therapy for broncho pulmonary dysplasia[J]. Exp Lung Res,2020,46(5):146-156. doi: 10.1080/01902148.2020.1751899
    [12] Jiang C, Li R, Ma X, et al. AMD3100 and SDF-1 regulate cellular functions of endothelial progenitor cells and accelerate endothelial regeneration in a rat carotid artery injury model[J]. Mol Med Rep, 2020 , 22(4): 3201-3212.
    [13] Newberry J,Desai S,Adler C,et al. SDF-1 preconditioned HPC scaffolds mobilize cartilage-derived progenitors and stimulate meniscal fibrocartilage repair in human explant tissue culture[J]. Connect Tissue Res,2020,61(3-4):338-348. doi: 10.1080/03008207.2019.1689966
    [14] Postnov A,Suslov A,Sobenin I,et al. Thoracic aortic aneurysm: Blood pressure and inflammation as key factors in the development of aneurysm dissection[J]. Curr Pharm Des,2021,27(28):3122-3127. doi: 10.2174/1381612827666210210142200
    [15] Edwin K Jackson,Delbert G Gillwepie,Stenan P Tofovic,et al. DPP4 Inhibition,NPY1-36,PYY1-36,SDF-1 α,and a hypertensive genetic background conspire to augment cell proliferation and collagen production: Effects that are abolished by low concentrations of 2-methoxyestradiol pharmacol exp ther[J]. Journal of Pharmacology & Experimental Therapeutics,2020,373(1):135-148.
  • [1] 徐艺铭, 朱红丽, 周欣颜, 梁婧.  4D—CTA成像对前交通动脉瘤破裂分险的相关性, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20231221
    [2] 丁煜昊, 王剑刃, 谢涛, 林荔青, 林泽西, 朱巍巍, 傅西安, 蒲军.  后交通动脉瘤破裂风险因素分析与评估, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20221210
    [3] 刘涛, 朱晓锋, 马俊, 李世鹏, 耿鑫, 李经辉, 余化霖, 白鹏.  颅内后交通动脉瘤破裂出血的临床特征和形态学的危险因素, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20211222
    [4] 杨斌, 杜伟, 段文帅.  能谱纯化技术在双能量CTA诊断颅内动脉瘤中的可行性, 昆明医科大学学报.
    [5] 黄鹞, 白鹏.  颈内动脉眼段未破裂动脉瘤的血管内治疗, 昆明医科大学学报.
    [6] 傅西安, 钱苏荣, 王剑刃, 林荔青, 桑春生, 潘耀华, 蒲军.  支架辅助弹簧圈栓塞颅内破裂动脉瘤并发症, 昆明医科大学学报.
    [7] 刘博虎, 蒲军, 高鸿, 常谦, 李俊彦, 岑键昌.  颅内破裂动脉瘤单纯弹簧圈填塞与支架辅助弹簧圈填塞比较分析, 昆明医科大学学报.
    [8] 罗剑渊.  26例支架辅助栓塞颅内宽颈动脉瘤的疗效分析, 昆明医科大学学报.
    [9] 王超.  颅内破裂动脉瘤的早期血管内介入治疗, 昆明医科大学学报.
    [10] 李东波.  颅内破裂动脉瘤的诊断研究, 昆明医科大学学报.
    [11] 张金鹏.  颅内未破裂动脉瘤43例临床体会, 昆明医科大学学报.
    [12] 张永生.  脾动脉瘤引起区域性门脉高压症1例报道, 昆明医科大学学报.
    [13] 贺振新.  多发性骨髓瘤中细胞因子信号转导抑制因子1(SOCS1)基因异常甲基化的研, 昆明医科大学学报.
    [14] 王为.  颅内动脉瘤夹闭术围手术期护理体会, 昆明医科大学学报.
    [15] 张明.  开颅手术夹闭治疗47例颅内破裂动脉瘤体会, 昆明医科大学学报.
    [16] 刘健刚.  趋化因子受体CXCR4在颅咽管瘤中的表达及其与预后的关系, 昆明医科大学学报.
    [17] 李滋聪.  DECTA对颅内微小动脉瘤的诊断价值, 昆明医科大学学报.
    [18] 谷震.  双微导管技术治疗颅内宽颈动脉瘤28例体会, 昆明医科大学学报.
    [19] 路华.  血管内介入栓塞治疗破裂前交通动脉瘤47例临床分析, 昆明医科大学学报.
    [20] 颅内动脉瘤显微手术围手术期护理, 昆明医科大学学报.
  • 加载中
图(6) / 表(4)
计量
  • 文章访问数:  447
  • HTML全文浏览量:  436
  • PDF下载量:  11
  • 被引次数: 0
出版历程
  • 收稿日期:  2023-12-15
  • 网络出版日期:  2024-03-12
  • 刊出日期:  2024-03-30

目录

    /

    返回文章
    返回