Changes of Coagulation Tetrad D Dimer and Pregnancy Outcome in Infertile Women before and after IVF Assisted Pregnancy

Jia-mei SONG; Jing-si CHEN; Yu-mei DENG; Zhi-jin HOU; Yu-shi MENG

doi:10.12259/j.issn.2095-610X.S20210124

Volume 42 Issue 1

Jan. 2021

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Article Navigation > Journal of Kunming Medical University > 2021 > 42(1): 85-88

Jia-mei SONG, Jing-si CHEN, Yu-mei DENG, Zhi-jin HOU, Yu-shi MENG. Changes of Coagulation Tetrad D Dimer and Pregnancy Outcome in Infertile Women before and after IVF Assisted Pregnancy[J]. Journal of Kunming Medical University, 2021, 42(1): 85-88. doi: 10.12259/j.issn.2095-610X.S20210124

Citation:

Jia-mei SONG, Jing-si CHEN, Yu-mei DENG, Zhi-jin HOU, Yu-shi MENG. Changes of Coagulation Tetrad D Dimer and Pregnancy Outcome in Infertile Women before and after IVF Assisted Pregnancy[J]. Journal of Kunming Medical University, 2021, 42(1): 85-88. doi: 10.12259/j.issn.2095-610X.S20210124

Citation:

Jia-mei SONG, Jing-si CHEN, Yu-mei DENG, Zhi-jin HOU, Yu-shi MENG. Changes of Coagulation Tetrad D Dimer and Pregnancy Outcome in Infertile Women before and after IVF Assisted Pregnancy[J]. Journal of Kunming Medical University, 2021, 42(1): 85-88. doi: 10.12259/j.issn.2095-610X.S20210124

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Changes of Coagulation Tetrad D Dimer and Pregnancy Outcome in Infertile Women before and after IVF Assisted Pregnancy

doi: 10.12259/j.issn.2095-610X.S20210124

Dept. of Gynaecology，The 2nd Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650101，China

Received Date: 2020-07-12
Available Online: 2021-01-26
Publish Date: 2021-01-26

Abstract

Abstract

Objective To explore the clinical significance of changes of coagulation tetrad and D-dimer（D-D）and pregnancy outcome in infertile women before and after IVF assisted pregnancy. Methods 115 cases of in vitro fertilization and embryo transfer were collected from June to November 2016 in the Department of Reproductive Medicine, the Second Affiliated Hospital of Kunming Medical University. Four coagulation and DD indexes were detected before and after IVF assisted pregnancy. According to whether the patients were pregnant, they were divided into the pregnancy group（69 cases）and non-pregnancy group（46 cases）. The changes of PT, APTT, FIB, TT and DD before and after IVF assisted pregnancy were compared between the two groups to see if there were any differences. Results The mean values of FIB and DD after IVF assisted pregnancy in pregnancy group were significantly higher than those before IVF assisted pregnancy（3.502±0.773、1.718±1.107 vs 2.875±0.625、0.706±3.101）, while TT was significantly lower than that before IVF assisted pregnancy（3.502±0.773 vs 2.875±0.635）, with significant difference（P < 0.05）; DD after IVF assisted pregnancy in non-pregnancy group was significantly higher than that before IVF assisted pregnancy（2.058±1.507 vs 0.294±0.244）, while TTF was significantly lower. The difference was significant before IVF assisted pregnancy（16.094±0.862 vs 16.830±1.697）（P < 0.05）. There was no significant difference in coagulation and DD between the pregnant group and non-pregnant group before and after IVF（P > 0.05）. Conclusion Detection of PT, APTT, FIB, TT and DD before and after IVF-ET assisted pregnancy in infertile women is helpful to detect abnormal coagulation function in time and improve the success rate of IVF-ET pregnancy in infertile women.
- Infertility,
- IVF,
- Coagulation,
- DD,
- Pregnancy outcome

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References(12)

References

[1]	Pierzynski P. Oxytocin and vasopressin V（1A）receptors asnew therapeutic targets in assistedreproduction [J/OL]. Reprod Biomed Online, 2011, 22（1）: 9-16;.
[2]	孟彩华. 血浆D-二聚体与血小板聚集检测在反复自然流产诊断中的应用价值[J].河南医学研究,2018,27(13):2403-2404. doi: 10.3969/j.issn.1004-437X.2018.13.055
[3]	宋芳,冯若鹏,赵紫薇,等. 孕酮对反复自然流产小鼠白介素8表达的调节作用[J].中国计划生育学杂志,2015,23(3):161-164,168.
[4]	孙莉,杨波,高艳霞,等. STR-2、E-cad与不明原因的反复自然流产相关性研究[J].现代生物医学进展,2015,15(30):5932-5934.
[5]	张永宏. 通元针法对排卵障碍性不孕症患者妊娠成功率的影响[J].上海针灸杂志,2019,38(5):520-524.
[6]	罗娜,刘水玉,邓伟芬. 控制性超促排卵中血清雌孕激素水平对子宫内膜容受性的影响[J].中国医药指南,2015,13(12):38-39.
[7]	张丽,杜丽荣,王树松. 胚胎移植反复种植失败的原因及治疗研究进展[J].中国计划生育学杂志,2017,25(8):559-562.
[8]	Ricci G,Bogatti P,Fischer-Tamaro L,et al. Factor V leiden and prothrombin gene G20210A mutation and in vitro fertilization:a prospective cohortstudy[J]. Hum Reprod,2011,26(11):3068-3077.
[9]	张建平,吴晓霞. 血栓前状态与复发性流产[J].中国实用妇科与产科杂志,2007,23(12):917-920. doi: 10.3969/j.issn.1005-2216.2007.12.011
[10]	Chan W S,Lee A,Spencer F A,et al. D-dimer testing in pregnant patients:towards determining the next‘level’ in the diagnosis of deep vein thrombosis[J]. J Thromb Haemost,2010,8(5):1004-1011.
[11]	de Vries J I,van Pampus M G,Hague W M,et al. Low-molecular-weight heparin added to aspirin in the prevention of recurrent early-onset pre-eclampsia in women with inheritable thrombophilia:The FRUIT-RCT[J]. J Thromb Haemost,2012,10(1):64-72. doi: 10.1111/j.1538-7836.2011.04553.x
[12]	袁燕,郑九生. 低分子肝素在产科应用中的研究进展[J].现代妇产科进展,2016,25(8):631-632.

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