Intestinal Barrier Damage Caused by Drug Dependence

Pu XIONG; Zun-yue ZHANG; Kun-hua WANG

doi:10.12259/j.issn.2095-610X.S20210131

Volume 42 Issue 1

Jan. 2021

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Pu XIONG, Zun-yue ZHANG, Kun-hua WANG. Intestinal Barrier Damage Caused by Drug Dependence[J]. Journal of Kunming Medical University, 2021, 42(1): 161-166. doi: 10.12259/j.issn.2095-610X.S20210131

Citation:

Pu XIONG, Zun-yue ZHANG, Kun-hua WANG. Intestinal Barrier Damage Caused by Drug Dependence[J]. Journal of Kunming Medical University, 2021, 42(1): 161-166. doi: 10.12259/j.issn.2095-610X.S20210131

Pu XIONG, Zun-yue ZHANG, Kun-hua WANG. Intestinal Barrier Damage Caused by Drug Dependence[J]. Journal of Kunming Medical University, 2021, 42(1): 161-166. doi: 10.12259/j.issn.2095-610X.S20210131

Citation:

Pu XIONG, Zun-yue ZHANG, Kun-hua WANG. Intestinal Barrier Damage Caused by Drug Dependence[J]. Journal of Kunming Medical University, 2021, 42(1): 161-166. doi: 10.12259/j.issn.2095-610X.S20210131

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Intestinal Barrier Damage Caused by Drug Dependence

doi: 10.12259/j.issn.2095-610X.S20210131

Pu XIONG^{1, 2},
Zun-yue ZHANG¹,
Kun-hua WANG^{1, 2
,
,}

1.
NHC Key Laboratory of Drug Addiction Medicine，Kunming Medical University，Kunming Yunnan 650500，China
2.
Dept. of Gastrointestinal and Hernia Surgery，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032，China

Received Date: 2020-06-22
Available Online: 2021-01-26
Publish Date: 2021-01-26

Abstract

Abstract

Drug dependence is considered as a serious chronic recurrent encephalopathy. Long-term use of addictive substances will lead to the occurrence and development of related comorbidities including the central nervous system, respiratory system, circulatory system and digestive system. Due to its special anatomical position and physiological function, the intestinal barrier plays an important role in preventing “foreign enemy invasion” and maintaining body homeostasis. This article focuses on the composition and function of the intestinal barrier, and studies on intestinal barrier damage caused by addictive substances （amfetamines, opioids, alcohol, etc.）, and provides theories for further elucidating the mechanism of intestinal barrier damage caused by addictive substances and the later researches.
- Addictive substance,
- Intestinal barrier,
- Injury,
- Review

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References(49)

References

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