Comparative Study on Anti-inflammatory and Antimicrobial Effects for Two Kinds of the Resin Gel

Li-han YANG; Zhi-bi ZHANG; Hui YANG; Jiang-lan YANG; Dan MAO; Xiao-li YANG; Chao-yu LUO; Yuan ZHANG; Rong-ping ZHANG

doi:10.12259/j.issn.2095-610X.S20210134

Volume 42 Issue 1

Jan. 2021

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Article Navigation > Journal of Kunming Medical University > 2021 > 42(1): 6-11

Li-han YANG, Zhi-bi ZHANG, Hui YANG, Jiang-lan YANG, Dan MAO, Xiao-li YANG, Chao-yu LUO, Yuan ZHANG, Rong-ping ZHANG. Comparative Study on Anti-inflammatory and Antimicrobial Effects for Two Kinds of the Resin Gel[J]. Journal of Kunming Medical University, 2021, 42(1): 6-11. doi: 10.12259/j.issn.2095-610X.S20210134

Citation:

Li-han YANG, Zhi-bi ZHANG, Hui YANG, Jiang-lan YANG, Dan MAO, Xiao-li YANG, Chao-yu LUO, Yuan ZHANG, Rong-ping ZHANG. Comparative Study on Anti-inflammatory and Antimicrobial Effects for Two Kinds of the Resin Gel[J]. Journal of Kunming Medical University, 2021, 42(1): 6-11. doi: 10.12259/j.issn.2095-610X.S20210134

Citation:

Li-han YANG, Zhi-bi ZHANG, Hui YANG, Jiang-lan YANG, Dan MAO, Xiao-li YANG, Chao-yu LUO, Yuan ZHANG, Rong-ping ZHANG. Comparative Study on Anti-inflammatory and Antimicrobial Effects for Two Kinds of the Resin Gel[J]. Journal of Kunming Medical University, 2021, 42(1): 6-11. doi: 10.12259/j.issn.2095-610X.S20210134

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Comparative Study on Anti-inflammatory and Antimicrobial Effects for Two Kinds of the Resin Gel

doi: 10.12259/j.issn.2095-610X.S20210134

1.
Biomedical Engineering Research center of Kunming Medical University
2.
College of Pharmacy，Yunnan University of Traditional Chinese Medicine, Kunming Yunnan 650500, China

Received Date: 2020-07-13
Available Online: 2021-01-26
Publish Date: 2021-01-26

Abstract

Abstract

Objective To comparatively study the anti-inhibitory and bacteriostatic effects of RDD and RDC gel so as to provide the laboratory basis for the development and utilization of the resin. Methods The model of the mouse pinna swelling induced by xylene and granuloma induced by cotton ball was adopted to test the anti-inflammatory effects of two kinds of the resin gel and the bacteriostatic effects of two kinds of the resin gel on Staphylococcus aureus, Staphylococcus epidermidis, Propionibacterium Acne, Candida albicans and Escherichia coli were compared by means of broth medium colorimetry. Results Compared with the blank control group in the test of auricle swelling induced by xylene, momethasone furoate gel（0.1 mg/） and high dose（12 mg/） of RDD gel inhibited the auricle swelling in mice（P < 0.05）, but there were no statistical differences in the other two groups（P > 0.05）; Compared with the momethasone furoate o gel group, the blank control group and the high dose RDD group had the significant difference（P < 0.05）, but there were no statistical differences in the other two groups（P > 0.05）. Compared with the blank control group in the experiment of granuloma model caused by cotton ball, the low dose RDC gel group had inhibitory effect on granulomal in mice, but there were no statistical differences in the other two groups（P > 0.05）; Compared with the mometasone furoate group, the blank control group and the high dose RDD blood group had the significant differences（P < 0.05） but there were no statistical differences in the other groups（P > 0.05）. The two kinds of resin gels had the inhibition to Staphylococcus aureus, Staphylococcus epidermidis, Propionibacterium Acne, Candida albicans and Escherichia coli. The minimal inhibitory concentration（MIC） of RDC gel was 50mg/mL and RDD gel was 200mg/mL for staphylococcus aureus and staphylococcus epidermidis; the MIC of propionibacterium acnes RDD gel and dragon resin gel were 100 mg/mL and 50 mg/mL, ; the MIC of Candida albicans RDD gel and RDC gel were 100 mg/mL and 200 mg/mL, respectively; the MIC of E. coli RDD gel and RDC gel were 100 mg/mL. Conclusion Both RDD gel and RDC gel have the anti-inflammatory and bacteriostatic effects. The RDC gel is superior to RDD gel in inhibiting granuloma of mouse cotton ball and fighting against Staphylococcus aureus, Staphylococcus epidermidis and Propionibacterium Acne; the effect of RDD gel on inhibiting auricle swelling induced by xylene in mice is better than that of RDC gel. There is the same bacteriostatic effect in the two kinds of resin gel on E. coli.
- RDD,
- RDC,
- Gel,
- Inflammation,
- Bacteriostatic

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