Expression and Significance of Serum HIF-1α in Patients with Chronic Kidney Disease

Shu-yun YANG; Min JI; Wen-xi ZHAO; Xiao-na LI; Rui LI; Dai-yu SHEN; Zi-juan SUN; Shi-li SHANG; Jing-shan CHEN; Jun LI

doi:10.12259/j.issn.2095-610X.S20210136

Volume 42 Issue 1

Jan. 2021

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Shu-yun YANG, Min JI, Wen-xi ZHAO, Xiao-na LI, Rui LI, Dai-yu SHEN, Zi-juan SUN, Shi-li SHANG, Jing-shan CHEN, Jun LI. Expression and Significance of Serum HIF-1α in Patients with Chronic Kidney Disease[J]. Journal of Kunming Medical University, 2021, 42(1): 64-67. doi: 10.12259/j.issn.2095-610X.S20210136

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Expression and Significance of Serum HIF-1α in Patients with Chronic Kidney Disease

doi: 10.12259/j.issn.2095-610X.S20210136

1.
Dept.of Nephrology，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032
2.
Dept.of Nephrology，The People’s Hospital of Zhengxiong County，Zhengxiong Yunnan 657200
3.
Dept.of Nephrology，The People’s Hospital of Chuxiong Prefecture，Chuxiong Yunnan 675000
4.
Dept.of Nephrology，The 3rd Hospital of Yunnan Province，Kunming Yunnan 650011，China

Received Date: 2020-11-24
Publish Date: 2021-01-25

Abstract

Abstract

Objective To study the expression of HIF-1α in the serum of CKD patients, analyze the relationship between it and serum fibrosis index PⅢNP, and the clinical indicators of CKD patients, and explore the clinical application value of HIF-1α in CKD. Methods A total of 63 CKD patients were randomly selected as the research object, and the research objects were grouped according to the CKD stage. 30 patients in CKD1-2 were in group A, 17 patients in CKD3 were in group B, and 16 patients in CKD4-5 were in group C.ELISA method was used to detect the expression of HIF-1α and PⅢNP in the serum of the enrolled patients, and the clinical data of the enrolled patients were collected, including gender, age, blood routine, liver function, renal function, ions, and 24-hour urine protein. Results HIF-1α was positively correlated with PⅢNP, Scr, BUN, γ-GT（P < 0.05）, negatively correlated with GFR, HB, Blood calcium（ P < 0.05）, There was no correlation with NLR, PLR, ALB, Phosphorus and 24-hour urine protein（ P > 0.05）. Conclusion HIF-1α is associated with serum fibrosis indexes, renal function, CKD complications, and may be involved in the progression of CKD disease, which can be used as one of the indicators for evaluating CKD.
- Chronic kidney disease,
- HIF-1α,
- PⅢNP,
- Renal interstitial fibrosis

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