Effect of Dexmedetomidine Combined with Nalbuphine in Meningioma Surgery on Postoperative Cognitive Function

Li-jia PENG; Yuan YANG; Ran GUO; Li XIONG; Jun-jie LI; Jian-lin SHAO; Wei-jun ZENG

doi:10.12259/j.issn.2095-610X.S20210306

Volume 42 Issue 3

Apr. 2021

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Article Navigation > Journal of Kunming Medical University > 2021 > 42(3): 18-22

Li-jia PENG, Yuan YANG, Ran GUO, Li XIONG, Jun-jie LI, Jian-lin SHAO, Wei-jun ZENG. Effect of Dexmedetomidine Combined with Nalbuphine in Meningioma Surgery on Postoperative Cognitive Function[J]. Journal of Kunming Medical University, 2021, 42(3): 18-22. doi: 10.12259/j.issn.2095-610X.S20210306

Citation:

Li-jia PENG, Yuan YANG, Ran GUO, Li XIONG, Jun-jie LI, Jian-lin SHAO, Wei-jun ZENG. Effect of Dexmedetomidine Combined with Nalbuphine in Meningioma Surgery on Postoperative Cognitive Function[J]. Journal of Kunming Medical University, 2021, 42(3): 18-22. doi: 10.12259/j.issn.2095-610X.S20210306

Citation:

Li-jia PENG, Yuan YANG, Ran GUO, Li XIONG, Jun-jie LI, Jian-lin SHAO, Wei-jun ZENG. Effect of Dexmedetomidine Combined with Nalbuphine in Meningioma Surgery on Postoperative Cognitive Function[J]. Journal of Kunming Medical University, 2021, 42(3): 18-22. doi: 10.12259/j.issn.2095-610X.S20210306

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Effect of Dexmedetomidine Combined with Nalbuphine in Meningioma Surgery on Postoperative Cognitive Function

doi: 10.12259/j.issn.2095-610X.S20210306

1.
Dept. of Anesthesiology，The First Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032
2.
ICU of the Second Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650101，China

Received Date: 2020-01-08
Publish Date: 2021-04-09

Abstract

Abstract

Objective To investigate the effect of dexmedetomidine （Dex）combined with nalbuphine in meningioma surgery on inflammation and postoperative cognitive function. Methods From July 2018 to March 2019, 60 patients who underwent elective meningioma resection in the First Affiliated Hospital of Kunming Medical University and met the inclusion criteria were randomly divided into Dex combined with nalbuphine group （DN group, n = 30） and Dex group （D group, n = 30）. In the DN group, nalbuphine hydrochloride 0.2 mg/kg was injected intravenously 5 minutes before the skin incision, and Dex was injected with a pump of 1 μg/kg 30 minutes before induction, and then changed to 0.5 μg（kg·h）, and the pump was continued until meninges are sutured. Give Dex the same plan for Group D. The rest of the anesthesia scheme is same. Results After extubation, the HR and MAP in the DN group were lower than those in the D group （P < 0.05）, and the hospital stay in the DN group was significantly shorter （P < 0.05）. At the same time, the concentrations of IL-6, IL-10, and TNF-α in the DN group were lower than those in the D group; compared with the same group, the IL-6, IL-10, and TNF-α concentrations in the DN group increased less than that in the D groupbefore the operation. The 6 h and 24 h MMSE scores in the DN group were significantly higher than those in the D group （P < 0.05）; compared with preoperatively, the 6 h MMSE score in the DN group was significantly lower （P < 0.05）, and the 6 h and 24 h simple mental scale in the D group （MMSE） score was significantly lower （P < 0.05）. Conclusions Dex combined with nalbuphine can better maintain hemodynamic indexes for patients undergoing meningioma resection, reduce the inflammatory response of the patients, have a smaller impact on the postoperative cognitive function of the patients, and shorten the hospital stay.
- Dexmedetomidine,
- Nalbuphine,
- Meningioma surgery,
- Cognitive function

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References(25)

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