Association of ABCG2，SLC2A9，SLC17A3 and PRKG2 SNPs Variants with Gout in the Hani Population in China

Dong-yun LI; Shun-kui GANG; Jie LI; Ming-xing ZHANG; Lei LI

doi:10.12259/j.issn.2095-610X.S20210320

Volume 42 Issue 3

Apr. 2021

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Article Navigation > Journal of Kunming Medical University > 2021 > 42(3): 54-60

Dong-yun LI, Shun-kui GANG, Jie LI, Ming-xing ZHANG, Lei LI. Association of ABCG2，SLC2A9，SLC17A3 and PRKG2 SNPs Variants with Gout in the Hani Population in China[J]. Journal of Kunming Medical University, 2021, 42(3): 54-60. doi: 10.12259/j.issn.2095-610X.S20210320

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Dong-yun LI, Shun-kui GANG, Jie LI, Ming-xing ZHANG, Lei LI. Association of ABCG2，SLC2A9，SLC17A3 and PRKG2 SNPs Variants with Gout in the Hani Population in China[J]. Journal of Kunming Medical University, 2021, 42(3): 54-60. doi: 10.12259/j.issn.2095-610X.S20210320

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Association of ABCG2，SLC2A9，SLC17A3 and PRKG2 SNPs Variants with Gout in the Hani Population in China

doi: 10.12259/j.issn.2095-610X.S20210320

1.
Dept. of Preventive Treatment of Disease，Kunming Municipal Hospital of Traditional Chinese Medicine，Kunming Yunnan 650051
2.
Dept. of Specialist Clinics，Ninger Hani and Yi Autonomous County Hospital of traditional Chinese Medicine，Ninger Yunnan 665100
3.
Dept. of Ophthalmology
4.
Dept. of Traditional Chinese Medicine Orthopedics，Kunming Municipal Hospital of Traditional Chinese Medicine，Kunming Yunnan 650051，China

Received Date: 2020-01-08
Publish Date: 2021-04-09

Abstract

Abstract

Objective To analyze the genetic characteristics and genetic mechanisms in the Hani and Han population by studying the association of five single nucleotide polymorphisms （SNPs） in four gene with gout. Methods A total of 100 Hani gout group, 126 Hani normal control group, 100 Hani gout group, 108 Han normal control group were enrolled in this study. Genotyping of the ABCG2, SLC2A9, SLC17A3 and PRKG2 was determined by cloning and sequencing of PCR amplicons and SNaPshot. SPSS version 20.0 was used for statistical calculations. Results The results showed that the genotype （P = 0.002） and allele （P = 0.024） frequency at the rs2231142 site was significantly associated with Hyperuricemia in Hani populations. In the Han populations, the genotype （P = 0.018） and allele （P = 0.034） frequency at the rs7688672 site was significantly associated with Hyperuricemia. In addition, the genotype frequency at the rs1165205 site was significantly associated with Hyperuricemia in Han populations （P = 0.037）. Conclusion ABCG2 rs2231142, SLC17A3 rs1165205 and PRKG2 rs7688672 polymorphisms are able to affect the risk of gout, which provides a potential candidate biomarker for screening, diagnosis, and treatment of gout and Hyperuricemia.
- Gout,
- Hyperuricemia,
- SNPs,
- Hani population

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References(22)

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