Advances in Research of Astrocyte-neuron Transformation in Vivo

Jin-shan TIE; Yao LIU; Shao-chun CHEN

doi:10.12259/j.issn.2095-610X.S20210333

Volume 42 Issue 3

Apr. 2021

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Jin-shan TIE, Yao LIU, Shao-chun CHEN. Advances in Research of Astrocyte-neuron Transformation in Vivo[J]. Journal of Kunming Medical University, 2021, 42(3): 140-144. doi: 10.12259/j.issn.2095-610X.S20210333

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Jin-shan TIE, Yao LIU, Shao-chun CHEN. Advances in Research of Astrocyte-neuron Transformation in Vivo[J]. Journal of Kunming Medical University, 2021, 42(3): 140-144. doi: 10.12259/j.issn.2095-610X.S20210333

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Advances in Research of Astrocyte-neuron Transformation in Vivo

doi: 10.12259/j.issn.2095-610X.S20210333

School of Rehabilitation，Kunming Medical University，Kunming Yunnan 650500，China

Received Date: 2020-12-16
Publish Date: 2021-04-09

Abstract

Abstract

Astrocyte-neuron transformation （ANT） is an important discovery in neuroscience field in the 21st century. Astrocytes are the largest number of glial cells and originate from the same precursor cells as neurons. Their potential to transform into neurons has brought new hope for the treatment of various neurological diseases characterized by neuronal damage or loss. There have been many successful experiments on the transformation of astrocyte-neuron in vitro, but the exploration in vivo is just beginning. Transcription factors, drugs, and microRNAs have been found to induce this transformation in animal models. Meanwhile, astrocyte-neuron transformation can be induced by pathological conditions such as Alzheimer’ s disease, spinal cord injury, focal stroke, and Parkinson’ s disease. In this paper, we systematically review the current status of studies on the transformation of astrocytes into neurons in normal and related disease animal models, and sort out the possible mechanisms of astrocytes’ reprogramming, neuronal transformation, then supplement and integration into damaged neural circuits.
- Astrocytes,
- Neuron,
- Astrocytes neuron transformation,
- Reprogramming,
- Central nervous system diseases

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References(27)

References

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