Expression of B7-H4 in Intrahepatic Cholangiocarcinoma and Its Clinical Significance

Gang LI; Jin-song LI; Nan XIE; Chun-mang LI; Lei WEI; Fan CAO; Ying-zhen SU

doi:10.12259/j.issn.2095-610X.S20210415

Volume 42 Issue 4

Apr. 2021

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Article Navigation > Journal of Kunming Medical University > 2021 > 42(4): 78-83

Gang LI, Jin-song LI, Nan XIE, Chun-mang LI, Lei WEI, Fan CAO, Ying-zhen SU. Expression of B7-H4 in Intrahepatic Cholangiocarcinoma and Its Clinical Significance[J]. Journal of Kunming Medical University, 2021, 42(4): 78-83. doi: 10.12259/j.issn.2095-610X.S20210415

Citation:

Gang LI, Jin-song LI, Nan XIE, Chun-mang LI, Lei WEI, Fan CAO, Ying-zhen SU. Expression of B7-H4 in Intrahepatic Cholangiocarcinoma and Its Clinical Significance[J]. Journal of Kunming Medical University, 2021, 42(4): 78-83. doi: 10.12259/j.issn.2095-610X.S20210415

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Expression of B7-H4 in Intrahepatic Cholangiocarcinoma and Its Clinical Significance

doi: 10.12259/j.issn.2095-610X.S20210415

1.
Dept. of Hepatobiliary Surgery，Cancer Hospital of Chengdu Medical College，The Seventh People’s Hospital of Chengdu，Chengdu Sichuan 610000
2.
The 4th Area，Dept. of Hepatobiliary and Pancreas Surgery，The Second Affiliated Hospital of Kunming Medical University ，Kunming Yunnan 650101
3.
Dept. of Laboratory Science and Preventive Medicine，Kunming University，Kunming Yunnan 650214，China

Received Date: 2021-01-08
Publish Date: 2021-04-01

Abstract

Abstract

Objective To investigate the expression of costimulatory molecule B7-H4 in intrahepatic cholangiocarcinoma （ICC）and its clinical significance. Methods Immunohistochemistry was used to detect the expression of B7-H4 in 90 cases of intrahepatic cholangiocarcinoma and its adjacent tissues, and analyzed the correlation between B7-H4 expression and the clinicopathological characteristics and prognosis of the patients. Results The expression rate of B7-H4 in intrahepatic cholangiocarcinoma was 44.4%, which was significantly higher than that of adjacent tissues. The increased expression of B7-H4 in intrahepatic cholangiocarcinoma was related to TNM staging, tumor differentiation, lymph node metastasis and poor prognosis （P < 0.05）. Survival analysis revealed that the overall survival rate of patients in the B7-H4 high expression group was significantly lower than that in the B7-H4 low expression group （P = 0.005）. Cox proportional hazards regression model analysis showed that B7-H4 is an independent prognostic factor for patients with intrahepatic cholangiocarcinoma. Conclusion The expression of B7-H4 is increased in intrahepatic cholangiocarcinoma tissues, and the high expression of B7-H4 is closely related to the malignant pathological characteristics and poor prognosis of ICC patients, which has clinical guiding significance for predicting the prognosis of patients.
- Co-stimulatory molecule B7-H4,
- Intrahepatic cholangiocarcinoma,
- Pathology,
- Prognosis

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References(21)

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