Volume 42 Issue 5
May  2021
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Article Navigation >  Journal of Kunming Medical University  > 2021  >  42(5): 1-5
Zhi YAN, Jingang HAO, Yunyun SHANG. Value of VI-RADS Scoring System in Precision Treatment of Bladder Cancer[J]. Journal of Kunming Medical University, 2022, 43(3): 74-79. doi: 10.12259/j.issn.2095-610X.S20220322
Citation: Jie-chen QIN, Xiao-fei ZUO, Cheng ZOU, Cheng-jie TUO, Ke-tao ZHANG, Xiao-mei ZHANG, Qing ZHAO. Antimicrobial and Antitumor Zingiberaceae Diterpene Derivatives Prepared by Structure Modification[J]. Journal of Kunming Medical University, 2021, 42(5): 1-5. doi: 10.12259/j.issn.2095-610X.S20210501
shu

Antimicrobial and Antitumor Zingiberaceae Diterpene Derivatives Prepared by Structure Modification

doi: 10.12259/j.issn.2095-610X.S20210501
  • 1.

    School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products，Kunming Medical University，Kunming Yunnan 650500

  • 2.

    Faculty of Pharmacy，Yunnan University of Chinese Medicine，Kunming Yunnan 650500，China

  • Received Date: 2021-02-19
    Available Online: 2021-06-02
  • Publish Date: 2021-05-20
    Abstract
  •   Objective  Coronarin E, a diterpenoid was utilized to synthesize bioactive derivatives.  Method  Coronarin E underwent SeO2 oxidation, acylation and photosensitized oxidation, two butenolide derivatives were obtained, which were subjected to antimicrobial and cytotoxic bioassays.  Results  Two butenolide derivatives were obtained, one showed good antimicrobial activities and the other showed good cytotoxic activities against five cancer cell lines.  Conclusion  It’ s worth to synthetize bioactive derivatives from Zingiberceae diterpenoids.
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