The Expression and Significance of Eukaryotic Translation Initiation Factor-5A2 in Intrahepatic Cholangiocarcinoma

Shao-hua YANG; Zhou-Jun LIAO; Sheng HU; Mao-lin HONG; Zhi-Mei SONG; Qun WEI; Xiao-wen ZHANG

doi:10.12259/j.issn.2095-610X.S20210505

Volume 42 Issue 5

May 2021

Turn off MathJax

Article Contents

Article Navigation > Journal of Kunming Medical University > 2021 > 42(5): 24-28

Shao-hua YANG, Zhou-Jun LIAO, Sheng HU, Mao-lin HONG, Zhi-Mei SONG, Qun WEI, Xiao-wen ZHANG. The Expression and Significance of Eukaryotic Translation Initiation Factor-5A2 in Intrahepatic Cholangiocarcinoma[J]. Journal of Kunming Medical University, 2021, 42(5): 24-28. doi: 10.12259/j.issn.2095-610X.S20210505

Citation:

Shao-hua YANG, Zhou-Jun LIAO, Sheng HU, Mao-lin HONG, Zhi-Mei SONG, Qun WEI, Xiao-wen ZHANG. The Expression and Significance of Eukaryotic Translation Initiation Factor-5A2 in Intrahepatic Cholangiocarcinoma[J]. Journal of Kunming Medical University, 2021, 42(5): 24-28. doi: 10.12259/j.issn.2095-610X.S20210505

Citation:

Shao-hua YANG, Zhou-Jun LIAO, Sheng HU, Mao-lin HONG, Zhi-Mei SONG, Qun WEI, Xiao-wen ZHANG. The Expression and Significance of Eukaryotic Translation Initiation Factor-5A2 in Intrahepatic Cholangiocarcinoma[J]. Journal of Kunming Medical University, 2021, 42(5): 24-28. doi: 10.12259/j.issn.2095-610X.S20210505

PDF( 741 KB)

The Expression and Significance of Eukaryotic Translation Initiation Factor-5A2 in Intrahepatic Cholangiocarcinoma

doi: 10.12259/j.issn.2095-610X.S20210505

1.
Dept. of Hepatobiliary and Pancreatic Surgery
2.
Dept. of Pathology，The Second Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650101，China

Received Date: 2021-01-04
Available Online: 2021-06-02
Publish Date: 2021-05-20

Abstract

Abstract

Objective To study the expression of eukaryotic translation initiation factor 5A2 （eIF5A2） in intrahepatic cholangiocarcinoma and its correlation with nerve invasion and peripheral adipose tissue infiltration. Methods Paraffin sections from 156 patients with intrahepatic cholangiocarcinoma were collected from October 2013 to October 2020 in the Department of Hepatobiliary and Pancreatic Surgery, the Second Affiliated Hospital of Kunming Medical University, and the normal liver tissues from 30 cases of hepatic hemangioma undergoing partial hepatectomy were collected during the same period. In the control group, the immunohistochemical methods were used to detect the expression level of eIF5A2, and pathological data were collected to analyze the correlation between eIF5A2 and nerve invasion and peripheral adipose tissue infiltration. Results In 156 cases of intrahepatic cholangiocarcinoma tissue sections, 95 cases （60.9%） had high expression of eIF5A2. The high expression rate of eIF5A2 in normal liver tissue bile duct epithelium was 13.3%. The expression of eIF5A2 was significantly related to nerve invasion and peripheral adipose tissue infiltration （P < 0.05）. Conclusion eIF5A2 is highly expressed in intrahepatic cholangiocarcinoma and is significantly related to nerve invasion and surrounding adipose tissue infiltration.
- Intrahepatic cholangiocarcinoma,
- Eukaryotic translation initiation factor-5A2,
- Immunohistochemical staining

FullText(HTML)

References(27)

References

[1]	De Jong M C,Nathan H,Sotiropoulos G C,et al. Intrahepatic cholangiocarcinoma:An international multi-institutional analysis of prognostic factors and lymph node assessment[J]. J Clin Oncol,2011,29(23):3140-3145. doi: 10.1200/JCO.2011.35.6519
[2]	Guan X Y,Sham J S,Tang T C,et al. Isolation of a novel candidate oncogene within a frequently amplified region at 3q26 in ovarian cancer[J]. Cancer Res,2001,61(9):3806-3809.
[3]	Meng Q B,Peng J J,Qu Z W,et al. Eukaryotic initiation factor 5A2 and human digestive system neoplasms[J]. World J Gastrointest Oncol,2019,11(6):449-458. doi: 10.4251/wjgo.v11.i6.449
[4]	Bao Y,Lu Y L,Wang X,et al. Eukaryotic translation initiation factor 5A2 (eIF5A2) regulates chemoresistance in colorectal cancer through pithelial mesenchymal transition[J]. Cancer Cell Int,2015,15(2):1-7. doi: 10.1186/s12935-015-0250-9
[5]	Tang D J,Dong S S,Ma N F,et al. Overexpression of eukaryotic initiation factor 5A2 enhances cell motility and promotes tumor metastasis in hepatocellular carcinoma[J]. Hepatology,2010,51(4):1255-1263. doi: 10.1002/hep.23451
[6]	Tsang F H,Au V,Lu W J,et al. Prognostic marker microRNA-125b inhibits tumorigenic properties of hepatocellular carcinoma cells via suppressing tumorigenic molecule eIF5A2[J]. Dig Dis Sci,2014,59(10):2477-2487. doi: 10.1007/s10620-014-3184-5
[7]	Wu Y,Tang Y,Xie S,et al. Chimeric peptide supramolecular nanoparticles for plectin-1 targeted miRNA-9 delivery in pancreatic cancer[J]. Theranostics,2020,10(3):1151-1165. doi: 10.7150/thno.38327
[8]	Wei Y X,Chen G,You L,et al. Expression of eukaryotic translation initiation factor 5A2 in pancreatic adenocarcinoma and its correlation with the prognosis[J]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao,2013,35(6):634-638.
[9]	Meng Q B,Kang W M,Yu J C,et al. Overexpression of eukaryotic translation initiation factor 5A2 (EIF5A2) correlates with cell aggressiveness and poor survival in gastric cancer[J]. PLoS One,2015,10(3):e0119229. doi: 10.1371/journal.pone.0119229
[10]	Patel T. Increasing incidence and mortality of primary intrahepatic cholangiocarcinoma in the United States[J]. Hepatology,2001,33(6):1353-1357. doi: 10.1053/jhep.2001.25087
[11]	吴孟超, 吴在德. 黄家驷外科学[M]. 第7版. 北京: 人民卫生出版社, 2008: 1695.
[12]	Lu J,Zhao H W,Chen Y,et al. Eukaryotic translation initiation factor 5A2 is highly expressed in prostate cancer and predicts poor prognosis[J]. Exp Ther Med,2019,17(5):3741-3747.
[13]	Yang H,Li X D,Zhou Y,et al. Stemness and chemotherapeutic drug resistance induced by EIF5A2 overexpression in esophageal squamous cell carcinoma[J]. Oncotarget,2015,6(28):26079-26089. doi: 10.18632/oncotarget.4581
[14]	Chen W,Luo J H,Hua W F,et al. Overexpression of EIF-5A2 is an independent predictor of outcome in patients of urothelial carcinoma of the bladder treated with radical cystectomy[J]. Cancer Epidemiol Biomarkers Prev,2009,18(2):400-408. doi: 10.1158/1055-9965.EPI-08-0754
[15]	Wang F W,Guan X Y,Xie D. Roles of eukaryotic initiation factor 5A2 in human cancer[J]. Int J Biol Sci,2013,9(10):1013-1020. doi: 10.7150/ijbs.7191
[16]	韦颍昕,陈革,由磊,等. 真核翻译起始因子5A2在胰腺癌中的表达及与预后的相关性[J]. 中国医学科学院学报,2013,35(06):634-638. doi: 10.3881/j.issn.1000-503X.2013.06.009
[17]	孟庆彬. EIF5A2促进胃癌细胞增殖、侵袭的分子机制研究[D]. 北京: 北京协和医学院博士论文, 2013.
[18]	Marchet A,Mocellin S,Belluco C,et al. Gene expression profile of primary gastric cancer:Towards the prediction of lymph node status[J]. Ann Surg Oncol,2007,14(3):1058-1064. doi: 10.1245/s10434-006-9090-0
[19]	Xie D,Ma N F,Pan Z Z,et al. Overexpression of EIF-5A2 is associated with metastasis of human colorectal carcinoma[J]. Hum Pathol,2008,39(1):80-86. doi: 10.1016/j.humpath.2007.05.011
[20]	Liu R R,Lv Y S,Tang Y X,et al. Eukaryotic translation initiation factor 5A2 regulates the migration and invasion of hepatocellular carcinoma cells via pathways involving reactive oxygen species[J]. Oncotarget,2016,7(17):24348-24360. doi: 10.18632/oncotarget.8324
[21]	Fujimura K,Wright T,Strnadel J,et al. A hypusine-eIF5A-PEAK1 switch regulates the pathogenesis of pancreatic cancer[J]. Cancer Res,2014,74(22):6671-6681. doi: 10.1158/0008-5472.CAN-14-1031
[22]	Zhu W,Cai M Y,Tong Z T,et al. Overexpression of EIF5A2 promotes colorectal carcinoma cell aggressiveness by upregulating MTA1 through C-myc to induce epithelial-mesenchymaltransition[J]. Gut,2012,61(4):562-575. doi: 10.1136/gutjnl-2011-300207
[23]	Li Y,Fu L,Li J B,et al. Increased expression of EIF5A2,via hypoxia or gene amplification,contributes to metastasis and angiogenesis of esophageal squamous cell carcinoma[J]. Gastroenterology,2014,146(7):1701-1713. doi: 10.1053/j.gastro.2014.02.029
[24]	Luo J H,Hua W F,Rao H L,et al. Overexpression of EIF-5A2 predicts tumor recurrence and progression in pTa/pT1 urothelial carcinoma of the bladder[J]. Cancer Sci,2009,100(5):896-902. doi: 10.1111/j.1349-7006.2009.01126.x
[25]	Dong J S,Wu B,Zha Z L,et al. MicroRNA-588 regulates migration capacity and invasiveness of renal cancer cells by targeting EIF5A2[J]. Eur Rev Med Pharmacol Sci,2019,23(23):10248-10256.
[26]	Zhao K,Ye Z,Li Y,et al. LncRNA FTX contributes to the progression of colorectal cancer through regulating miR-192-5p/EIF5A2 axis[J]. Onco Targets Ther,2020,13(3):2677-2688.
[27]	Li X,He J,Ren X,Zhao H,et al. Circ_0003998 enhances doxorubicin resistance in hepatocellular carcinoma by regulating miR-218-5p/EIF5A2 pathway[J]. Diagn Pathol,2020,15(1):141-154. doi: 10.1186/s13000-020-01056-1

Relative Articles(20)

Relative Articles

[1]	Fei SONG, Yingying XIANG, Jiayin CHE, Hongyang LI, Wenyong XU, Lingxiao WEI, Ming HUANG. Clinical Comparison of Biliary Iodine-125 Stent and Bare Metal Stent in Treatment of Bismuth Corlette III Cholangiocarcinoma Complicated with Obstructive Jaundice. Journal of Kunming Medical University, 2022, 43(11): 85-89. doi: 10.12259/j.issn.2095-610X.S20221110
[2]	Yao ZOU, Ziyu WANG, Jiao LI, Xingxin LI, Yaqiong SHEN, Jing XU, Yan JIN. Association between LOXL2 and Snail Expression Levels and Overall Survival Rate after Surgery in Patients with Cholangiocarcinoma. Journal of Kunming Medical University, 2022, 43(12): 81-87. doi: 10.12259/j.issn.2095-610X.S20221215
[3]	Zhoujun LIAO, Shaohua YANG, Lixin LIU, Sheng HU, Yihui CHEN, Qiang KANG, Xiaowen ZHANG. Effect of AK4 on Proliferation and Migration of Intrahepatic Bile Duct Carcinoma Cell HUCCT1. Journal of Kunming Medical University, 2022, 43(6): 1-6. doi: 10.12259/j.issn.2095-610X.S20220611
[4]	Gang LI, Shaohua YANG, Meng SHEN, Nan XIE, Guanbo ZHANG, Jiaxing WANG, Jinsong LI. Expression and Clinical Significance of Eukaryotic Translation Initiation Factors 5A2 and Ki67 in Intrahepatic Cholangiocarcinoma. Journal of Kunming Medical University, 2022, 43(6): 7-12. doi: 10.12259/j.issn.2095-610X.S20220630
[5]	Liu-zheng LI, Shun LU, Shi-rong ZHANG, Lei-sheng XU, Hai-rong ZHAO, Jia-wei FENG, Xue-chan GAO, Tong WU. Curative Effect of Combined Hemihepatectomy and Perihilar Hepatectomy in Treatment of Hilar Cholangiocarcinoma. Journal of Kunming Medical University, 2021, 42(10): 121-126. doi: 10.12259/j.issn.2095-610X.S20211014
[6]	Zhi-qiang LI, Hong-qiang GAO, Jing-feng LI, Jie-qi YU, Dong-dong WANG, Gang CHEN, Guang CHU. Expression of ICAM-1, MMP-9 and NF-κB in Cholangiocarcinoma and Their Relationship with Immunosuppressive Cells in Peripheral Blood. Journal of Kunming Medical University, 2021, 42(11): 93-98. doi: 10.12259/j.issn.2095-610X.S20211117
[7]	Gang LI, Jin-song LI, Nan XIE, Chun-mang LI, Lei WEI, Fan CAO, Ying-zhen SU. Expression of B7-H4 in Intrahepatic Cholangiocarcinoma and Its Clinical Significance. Journal of Kunming Medical University, 2021, 42(4): 78-83. doi: 10.12259/j.issn.2095-610X.S20210415
[8]	Hou Feng Qiang , Dong Shan Chao , Lei Xi Feng , Zhang Wei . Effects of Paclitaxel on Gene and Protein Expression of wnt/β-catenin Signaling Pathway in Cholangiocarcinoma Cell Line QBC939. Journal of Kunming Medical University, 2017, 38(04): 10-13.
[9]	Kang Qiang . Expression of E-cadherin and Vimentin and Clinic Significance in Intrahepatic Cholangiocarcinoma. Journal of Kunming Medical University,
[10]	Li Zheng . The Diagnosis of Intrahepatic Bile Duct Stones with Early Intrahepatic Cholangiocarcinoma by Combining CA199, CEA, CA50 and ALP and Magnetic Resonance Imaging. Journal of Kunming Medical University,
[11]	Wang Ye . . Journal of Kunming Medical University,
[12]	Wang Tian Yang . . Journal of Kunming Medical University,
[13]	Yang Yan Mei . . Journal of Kunming Medical University,
[14]	Pan Yi Shuang . . Journal of Kunming Medical University,
[15]	Sun Hua . . Journal of Kunming Medical University,
[16]	Yang Shi Kun . . Journal of Kunming Medical University,
[17]	Huang Song Quan . . Journal of Kunming Medical University,
[18]	. The Treatment of Left Hepatolithiasis by Left External Lobectomy(a Report of 79 Cases). Journal of Kunming Medical University,
[19]	. Expression of Survivin in Differentiated Thyroid Carcinomas and Its Clinical Significance. Journal of Kunming Medical University,
[20]	Song Yu Feng . Pathologic Changes of Articular Cartilage in Ovariectomied Rats. Journal of Kunming Medical University,