The Electroencephalogram and Analysis of MPTP-Induced Tree Shrew Model for Parkinson's Disease

Bo LI; Jian-lin JIAO; Chuan-yi ZHANG; Ya-qiong QIU; Hao GUO; Huai-chang SUN; Zhi-cheng YU

doi:10.12259/j.issn.2095-610X.S20210506

Volume 42 Issue 5

May 2021

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Article Navigation > Journal of Kunming Medical University > 2021 > 42(5): 29-34

Bo LI, Jian-lin JIAO, Chuan-yi ZHANG, Ya-qiong QIU, Hao GUO, Huai-chang SUN, Zhi-cheng YU. The Electroencephalogram and Analysis of MPTP-Induced Tree Shrew Model for Parkinson's Disease[J]. Journal of Kunming Medical University, 2021, 42(5): 29-34. doi: 10.12259/j.issn.2095-610X.S20210506

Citation:

Bo LI, Jian-lin JIAO, Chuan-yi ZHANG, Ya-qiong QIU, Hao GUO, Huai-chang SUN, Zhi-cheng YU. The Electroencephalogram and Analysis of MPTP-Induced Tree Shrew Model for Parkinson's Disease[J]. Journal of Kunming Medical University, 2021, 42(5): 29-34. doi: 10.12259/j.issn.2095-610X.S20210506

Citation:

Bo LI, Jian-lin JIAO, Chuan-yi ZHANG, Ya-qiong QIU, Hao GUO, Huai-chang SUN, Zhi-cheng YU. The Electroencephalogram and Analysis of MPTP-Induced Tree Shrew Model for Parkinson's Disease[J]. Journal of Kunming Medical University, 2021, 42(5): 29-34. doi: 10.12259/j.issn.2095-610X.S20210506

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The Electroencephalogram and Analysis of MPTP-Induced Tree Shrew Model for Parkinson's Disease

doi: 10.12259/j.issn.2095-610X.S20210506

Bo LI^{1, 2},
Jian-lin JIAO³,
Chuan-yi ZHANG⁴,
Ya-qiong QIU⁴,
Hao GUO⁴,
Huai-chang SUN^{1
,
,},
Zhi-cheng YU^{4
,
,}

1.
Veterinary Medicine Department，Yangzhou University，Yangzhou Jiangsu 225009
2.
Biomedical Engineering Research Center
3.
Technology Transferring Center
4.
Basic Medical School，Kunming Medical University，Kunming Yunnan，650500，China

Received Date: 2021-02-16
Available Online: 2021-06-02
Publish Date: 2021-05-20

Abstract

Abstract

Objective To study the characteristics of cortical electroencephalogram （EEG）, power spectrum and mapping in tree shrew model for Parkinson’ s disease （PD）. Methods Ten common-level Burmese adult tree shrews were selected and randomly divided into a model group (n = 5) and a control group （n = 5）. A PD model of tree shrew was produced by intramuscular injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine （MPTP）, with a MPTP dose of 2 mg/kg. The control group was injected with an equal volume of 0.9% sodium chloride solution continuously for 15 days. One month after the drug withdrawal, EEG technology was used to perform the cortical EEG tracing, power spectrum and topographic analysis of the tree shrew PD model. Results The MPTP-Induced Tree Shrew Model for PD was established successfully. In the normal control group, there was no significant difference and specificity in frequency, amplitude, waveform and phase of EEG in the frontal, parietal and occipital parts of the cerebral hemisphere,α wave was dominant in the waves recorded in each part of the tree shrews brain and amplitude difference was less than 30%, with δ and θ waves being scattered; The histogram of EEG power spectrum was basically symmetrical on both sides; The power value of each frequency band was distributed symmetrically in the two hemispheres and the bilateral six bands in the EEG mapping was low power and its power value was less than 100 μv²/Hz. In the tree shrew PD model group, spikes, sharp waves and other abnormal waves were recorded, showing rhythmic emission. The mainly manifested α wave was asymmetry, the abnormal waveforms were mainly in the frontal and parietal areas, and the high amplitude slow waves δ、θ also appeared in some areas; The main features of EEG power spectrum were as follows: α wave phase was not synchronous, and the histogram distribution of power spectrum in each frequency band was asymmetric; The δ frequency band in the EEG mapping was low frequency and high power and the average power was more than 1 000 μv²/Hz. Compared with the control group, the frequency band power values of δ、θ、α1and α2 were significantly higher than those of the control group. Conclusion Compared with the normal control group, the EEG waveforms, EEG spectrum histogram and EEG mapping in the tree shrew PD model all show the significant characteristics, proving that they can provide references for the study of neuroelectrophysiology in PD model.
- Electroencephalography,
- EEG power spectrum,
- EEG mapping,
- Parkinson’ s model,
- Tree shrew,
- MPTP

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