Volume 42 Issue 5
May  2021
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Article Navigation >  Journal of Kunming Medical University  > 2021  >  42(5): 81-86
Li ZHANG, Linjia XUE, Lirong YUE, Yong CHEN, Yu DING, Huanyu ZHANG. Effect of MDT Model in the Treatment of Anterior Displacement of Irreducible Disc of Temporomandibular Joint[J]. Journal of Kunming Medical University, 2022, 43(4): 44-49. doi: 10.12259/j.issn.2095-610X.S20220409
Citation: Yong-ji FU, Fei PENG, Mei GUO, Hua YAN, Qing-cheng SHEN, Jin-xi BAI, Liu YANG. Clinical Characteristics of Gastric Cancer in Young Patients: A Retrospective Cohort Study[J]. Journal of Kunming Medical University, 2021, 42(5): 81-86. doi: 10.12259/j.issn.2095-610X.S20210515
shu

Clinical Characteristics of Gastric Cancer in Young Patients: A Retrospective Cohort Study

doi: 10.12259/j.issn.2095-610X.S20210515
  • 1.

    Dept. of Gastroenterology,Shanghai Ninth People’s Hospital，Shanghai Jiaotong University，School of Medicine，Shanghai 200011

  • 2.

    Dept. of Surgery，Shanghai Jing’an Dist. Hospital，Fudan University，Shanghai，200040

  • 3.

    Dept. of Medical Records，Shanghai Ninth People’s Hospital，Shanghai Jiaotong University，School of Medicine，Shanghai 200011，China

  • Received Date: 2021-02-19
  • Publish Date: 2021-05-25
    Abstract
  •   Objective   The rate of gastric cancer in young patients has increased over the past few decades. The aim of this study was to analyze the clinical characteristics of young patients with gastric cancer, and investigate the possible risk factors that may be related to the survival rate of young patients.   Methods   From January 2005 to December 2015 a series of 535 consecutive patients were admitted to our hospitals because of a gastric cancer. We carried out a retrospective cohort study in 81 patients younger than 40 years old and in 454 patients aged 40 years older. The comparison was involved in the evaluation of patient and tumor characteristics.   Results   The proportion of the female in the young group was higher than that in the middle-aged and old group. The young patients had significantly more preoperative abdominal pain, while the elder had more weight loss as well as upper gastrointestinal bleeding and abdominal pain. There was no significance in duration of symptoms before the diagnosis between the two groups; In terms of lesion, pathological change occurred at the antrum or full stomach was seen more often in young patients, while elderly patients often had lesions at the upper part of corpus or the fundus. Helicobacter pylori infection and diffuse histological type were significantly associated with younger age. There was also statistically significant difference regarding overall and cancer-related 5-year survival; advanced cancer stage and diffuse histological type were the independent negative prognostic factors influencing cancer-related survival.   Conclusion   In our study, the proportion of the female in young patiants was higher than that in the middle-aged and old patiants and had more Helicobacter pylori infection, as well as the diffuse histological type of gastric cancer along with poor cancer-related 5-year survival rate, but we do not have sufficient evidence to consider gastric cancer in female patients as a different clinical entity. Further studies are needed to understand carcinogenesis in younger patients, especially females.
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