Clinical Significance of Carboxyhemoglobin in Neonatal ABO Hemolytic Jaundice

Wan DENG; Yu-e ZHOU; Tian-yun LIU; Yan-zheng YANG; Li LIN

doi:10.12259/j.issn.2095-610X.S20210526

Volume 42 Issue 5

May 2021

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Wan DENG, Yu-e ZHOU, Tian-yun LIU, Yan-zheng YANG, Li LIN. Clinical Significance of Carboxyhemoglobin in Neonatal ABO Hemolytic Jaundice[J]. Journal of Kunming Medical University, 2021, 42(5): 143-146. doi: 10.12259/j.issn.2095-610X.S20210526

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Wan DENG, Yu-e ZHOU, Tian-yun LIU, Yan-zheng YANG, Li LIN. Clinical Significance of Carboxyhemoglobin in Neonatal ABO Hemolytic Jaundice[J]. Journal of Kunming Medical University, 2021, 42(5): 143-146. doi: 10.12259/j.issn.2095-610X.S20210526

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Clinical Significance of Carboxyhemoglobin in Neonatal ABO Hemolytic Jaundice

doi: 10.12259/j.issn.2095-610X.S20210526

1.
School of Nursing，Yunnan University of Traditional Chinese Medicine，Kunming Yunnan 650504
2.
Dept. of Paediatrics，The Third People’s Hospital of Yunnan Province，Kunming Yunnan 650011，China

Received Date: 2021-02-06
Available Online: 2021-06-08
Publish Date: 2021-05-20

Abstract

Abstract

Objective To investigate the clinical significance of carboxyhemoglobin （COHb） in neonatal ABO hemolytic jaundice. Methods Retrospective analysis was conducted and from January 2019 to December 2019, 68 cases of ABO hemolysis were selected as the observation group and at the same time, 60 cases of non-hemolytic pathological jaundice were selected as the control group. The peak levels of c0hb and total bilirubin （STB） of the two groups were compared and analyzed. Results The observation group’ s COHb （1.39±0.36） and STB （270.10±63.73） were higher than the control group’ s COHb （0.93±0.34）, STB （158.62±26.77）, difference was statistically significant （P < 0.01）; The area under the curve（AUC） of COHb diagnosis ABO hemolysis was 0.814, 78% sensitivity and the specificity was 72%. Conclusion COHb increases significantly in the early stage ABO neonatal hemolysis and it can be used as ABO early diagnosis reference index of hemolytic jaundice in newborns.
- Hyperbilirubinemia,
- Carboxyhemoglobin,
- ABO Hemolytic disease of newborn

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