The Pathogenesis of Acromegaly Complicated with Diabetes Mellitus

Jun ZHONG; Jing-yun FU

doi:10.12259/j.issn.2095-610X.S20210529

Volume 42 Issue 5

May 2021

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Jun ZHONG, Jing-yun FU. The Pathogenesis of Acromegaly Complicated with Diabetes Mellitus[J]. Journal of Kunming Medical University, 2021, 42(5): 159-164. doi: 10.12259/j.issn.2095-610X.S20210529

Citation:

Jun ZHONG, Jing-yun FU. The Pathogenesis of Acromegaly Complicated with Diabetes Mellitus[J]. Journal of Kunming Medical University, 2021, 42(5): 159-164. doi: 10.12259/j.issn.2095-610X.S20210529

Jun ZHONG, Jing-yun FU. The Pathogenesis of Acromegaly Complicated with Diabetes Mellitus[J]. Journal of Kunming Medical University, 2021, 42(5): 159-164. doi: 10.12259/j.issn.2095-610X.S20210529

Citation:

Jun ZHONG, Jing-yun FU. The Pathogenesis of Acromegaly Complicated with Diabetes Mellitus[J]. Journal of Kunming Medical University, 2021, 42(5): 159-164. doi: 10.12259/j.issn.2095-610X.S20210529

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The Pathogenesis of Acromegaly Complicated with Diabetes Mellitus

doi: 10.12259/j.issn.2095-610X.S20210529

Jun ZHONG,
Jing-yun FU^,

Dept.of Endocrinology，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032，China

Received Date: 2021-01-05
Available Online: 2021-06-08
Publish Date: 2021-05-20

Abstract

Abstract

Hypersecretion of GH in acromegaly produces the insulin resistance and is prone to diabetes mellitus.The main mechanism is that the insulin receptor and its substrate phosphorylation level, phosphatidylinositol 3 kinase regulatory subunit P85 level, glucose transport level and 11β-Hydroxysteroid Dehydrogenaseactivity play a series of roles through the growth hormone receptor, resulting in glucose metabolism disorder.
- Acromegaly,
- Growth hormone,
- Diabetes mellitus

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References(46)

References

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