The Mechanism of Histones and TLRs in Venous Thrombotic Diseases

Jie WU; Jun LIU; Yan ZHANG; Li REN; Yan-li DANG

doi:10.12259/j.issn.2095-610X.S20210530

Volume 42 Issue 5

May 2021

Turn off MathJax

Article Contents

Article Navigation > Journal of Kunming Medical University > 2021 > 42(5): 165-169

Jie WU, Jun LIU, Yan ZHANG, Li REN, Yan-li DANG. The Mechanism of Histones and TLRs in Venous Thrombotic Diseases[J]. Journal of Kunming Medical University, 2021, 42(5): 165-169. doi: 10.12259/j.issn.2095-610X.S20210530

Citation:

Jie WU, Jun LIU, Yan ZHANG, Li REN, Yan-li DANG. The Mechanism of Histones and TLRs in Venous Thrombotic Diseases[J]. Journal of Kunming Medical University, 2021, 42(5): 165-169. doi: 10.12259/j.issn.2095-610X.S20210530

Citation:

PDF( 547 KB)

The Mechanism of Histones and TLRs in Venous Thrombotic Diseases

doi: 10.12259/j.issn.2095-610X.S20210530

Dept. of Obstetrics，The First People’s Hospital of Yunnan Province; The Affiliated Hospital of Kunming University of Science and Technology，Kunming Yunnan 650032，China

Received Date: 2021-12-13
Available Online: 2021-06-03
Publish Date: 2021-05-20

Abstract

Abstract

In recent years, due to the increase of high-risk pregnancies in obstetrics and the improvement of diagnostic techniques, clinical attention to pregnancy complicated with venous thrombotic diseases is increasing from year to year. Although various risk factors that induce deep vein thrombosis have been identified, the mechanism of thrombosis is not yet completely clear. Studies have demonstrated that histones play a key role in venous thrombotic diseases, mediating the production of thrombus through inflammatory pathways or TLRs that activate inflammation.This article aims to provide an overview of histone-induced venous thrombotic diseases through TLRs to stimulate inflammation, and provide a new breakthrough point for the prevention and treatment of obstetric venous thrombotic diseases in the future.
- Histones,
- TLRs,
- Venous thrombotic diseases

FullText(HTML)

References(28)

References

[1]	Melis F,Vandenbrouke J P,Büller H R,et al. Estimates of risk ofvenous thrombosis during pregnancy and puerperium are not influenced by diagnosticsuspicion and referral basis[J]. Am J Obstet Gynecol,2004,191(3):825-829. doi: 10.1016/j.ajog.2004.02.004
[2]	Kourlaba G,Relakis J,Kontodimas S,et al. A systematic review and meta-analysis of the epidemiology and burden of venous thromboembolism among pregnant women[J]. IntJ Gynaecol Obstet,2016,132(1):4-10.
[3]	Parunov L A,Soshitova N P. Epidemiology of venous thromboembolism (VTE) associated with pregnancy[J]. Birth Defects Res C Embryo Today,2015,105(3):167-184.
[4]	Bates S M,Rajasekhar A,Middeldorp S. American Society of Hematology 2018 guidelines for management of venous thromboembolism:Venous thromboembolism in the context of pregnancy[J]. Blood Adv,2018,2(22):3317-3359. doi: 10.1182/bloodadvances.2018024802
[5]	McColl M D,Ellison J,GreerI A,et al. Prevalence of the post-thrombotic syndrome in young women with previous venous thromboembolism[J]. Br J Haematol,2000,108(2):272-274.
[6]	Rosfors S,Noren A,Hjertberg R,et al. A 16-year haemodynamic follow-up of women with pregnancy-related medically treated iliofemoral deep venous thrombosis[J]. Eur J Vasc Endovasc Surg,2001,22(5):448-455.
[7]	Wik H S,Jacobsen A F,Sandvik L,et al. Prevalence and predictors for post-thrombotic syndrome 3 to16 years after pregnancy-related venous thrombosis:Apopulation-based,cross-sectional,case-controlstudy[J]. J Thromb Haemost,2012,10(5):840-847. doi: 10.1111/j.1538-7836.2012.04690.x
[8]	赵晶斌,张晓鹏,周栋. 中性粒细胞外铺网在静脉血栓栓塞中的作用[J]. 中国组织工程研究,2019,23(12):1930-1935. doi: 10.3969/j.issn.2095-4344.1583
[9]	Brinkmann V,Reichard U,Goosmann C,et al. Neutrophil extracellular traps kill bacteria[J]. Science,2004,303(5663):1532-1535. doi: 10.1126/science.1092385
[10]	Fuchs T A,Abed U,Goosmann C,et al. Novel cell death program leads to neutrophil extracelluar traps[J]. J Cell Biol,2007,176(2):231-241. doi: 10.1083/jcb.200606027
[11]	齐昊喆,杨硕菲,阚科佳,等. 胞外组蛋白在静脉血栓形成相关机制中的研究进展[J]. 中华医学杂志,2016,47(96):3855-3856.
[12]	Abrams S T,Zhang N,Dart C,et al. Human CRP defends against the toxicity of circulating histones[J]. J Immunol,2013,191(5):2459-2502.
[13]	Zhao T,Li Y,Liu B,et al. Histone deacetylase inhibitor treatment attenuates coagulation imbalance in a lethal murine model of sepsis[J]. Surgery,2014,156(2):214-220. doi: 10.1016/j.surg.2014.04.022
[14]	Larsson P,Bergh N,Lu E,et al. Histone deacetylase inhibitors stimulate tissue-type plasminogen activator production in vascular endothelial cells[J]. J Thromb Thrombolysis,2013,35(2):185-192. doi: 10.1007/s11239-012-0831-6
[15]	Xu J,Zhang X,Pelayo R,et al. Extracellular histones are major mediators of death in sepsis[J]. Nat Med,2009,15(11):1318-1321. doi: 10.1038/nm.2053
[16]	Saffarzadeh M,Juenemann C,Queisser M A,et al. Neutrophil extracellular traps directly induce epithelial and endothelial cell death:A pre-dominant role of histones[J]. PLo One,2012,7(2):e32366. doi: 10.1371/journal.pone.0032366
[17]	Fuchs T A,Brill A,Duerschmied D,et al. Extracellular DNA traps promote thrombosis[J]. Proc Natl Acad Sci U S A,2010,107(36):15880-15885. doi: 10.1073/pnas.1005743107
[18]	Fuchs T A,Bhandari A A,Wagner D D. Histone induce rapid and profound thrombocytopenia in mice[J]. Blood,2011,118(13):3708-3714. doi: 10.1182/blood-2011-01-332676
[19]	Wang Y,Li M,Stadler S,et al. Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation[J]. J Cell Biol,2009,184(2):205-213. doi: 10.1083/jcb.200806072
[20]	Semeraro F,Ammollo C T,Morrissey J H,et al. Extracellular histones promote thrombin generation through platelet-dependent mechanisms:Involvement of platelet TLR2 and TLR4[J]. Blood,2011,118(7):1952-1961. doi: 10.1182/blood-2011-03-343061
[21]	Grasso S,Neumann A,Lang I M,et al. Interaction of factor Ⅶ ac- tivating protease(FSAP)with neutrophil extracellular traps(NETs)[J]. Thromb Res,2018,161(1):36-42.
[22]	Noubouossie D F,Whelihan M F,Yu Y B,et al. In vitro activation of coagulation by human neutrophil DNA and histone proteins but not neutrophil extracellular traps[J]. Blood,2017,129(8):1021-1029. doi: 10.1182/blood-2016-06-722298
[23]	Ammollo C T,Semeraro F,Xu J et al. Extracellular histonesincrease plasma thrombin generation by impairingthrombomodulin-dependentprotein C activation[J]. J Thromb Haemost,2011,9(9):1795-1803. doi: 10.1111/j.1538-7836.2011.04422.x
[24]	Gould T J,Vu T T,Swystun L L,Liaw P C. Neutrophil extracellular traps promote thrombin generation through platelet-dependent and platelet-independent mechanisms[J]. Arterioscler thromb Vasc Biol,2014,34(9):1977-1984. doi: 10.1161/ATVBAHA.114.304114
[25]	Gordon S. Pattern recognition receptors:Doubling up for the innate immuneresponse[J]. Cell,2002,111(7):927-930. doi: 10.1016/S0092-8674(02)01201-1
[26]	Taro K,Shizuo A. The role of pattern-recognition receptors in innate immunity:Update on Toll-like receptors[J]. Nat Immun,2010,11(5):373-384. doi: 10.1038/ni.1863
[27]	Cognasse F,Hamzeh H,Chavarin P,et al. Evidence of Toll-like receptor molecules on human platelets[J]. Immunol Cell Biol,2005,83(2):196-198. doi: 10.1111/j.1440-1711.2005.01314.x
[28]	Xu J,Zhang X,Monestier M,et al. Extracellular histones are mediators of death through TLR2 and TLR4 in mouse fatal liver injury[J]. J Immunol,2011,187(5):2626-2631. doi: 10.4049/jimmunol.1003930

Relative Articles(20)

Relative Articles

[1]	Bin LIN, Kai ZHANG, Jie WANG, Xinmin CHEN. Changes and Significance of D-D，F1+2 and P-selectin in Patients with Acute Deep Venous Thrombosis of Lower Extremities before and after Catheter-thrombolysis. Journal of Kunming Medical University, 2024, 45(1): 93-99. doi: 10.12259/j.issn.2095-610X.S20240116
[2]	Binbin MA, Ning WANG, Jianping LIU, Kaiquan ZHANG, Yongli GAO, Gaohui LI, Chen ZHANG. Risk Factors of Deep Vein Thrombosis after Soft Tissue Trauma of Lower Extremities. Journal of Kunming Medical University, 2023, 44(8): 110-116. doi: 10.12259/j.issn.2095-610X.S20230817
[3]	Juli SHEN, Huifang JIA, Mei GAO, Jinmei DUAN, Ping LIU, Zuyan SUN, Huixian LIN. Application of Cluster Nursing based on Risk Assessment in Prevention of Deep Vein Thrombosis of Lower Extremity after Total Hysterectomy. Journal of Kunming Medical University, 2022, 43(2): 160-165. doi: 10.12259/j.issn.2095-610X.S20220212
[4]	Hongjiang ZHOU, Juan TANG, Lei LIANG, Xin NIAN. Research Progress of Akkermansia Muciniphila and Obesity-related Metabolic Diseases. Journal of Kunming Medical University, 2022, 43(1): 157-162. doi: 10.12259/j.issn.2095-610X.S20220143
[5]	Ying YANG, Ren-lan LI, Lei SONG, Bin HE, Dong-mei ZHUANG. Application and Effect Evaluation of Integrated Intervention of Multiple Follow-up Methods in Discharged Patients with High Risk of Surgical Venous Thromboembolism. Journal of Kunming Medical University, 2021, 42(6): 170-174. doi: 10.12259/j.issn.2095-610X.S20210636
[6]	Yang Ying , He Bin , Zhuang Dong Mei , Song Lei , Gu Yan Hua , Li Cai E , Li Xia . . Journal of Kunming Medical University, 2020, 41(07): 175-178.
[7]	Yang Xue Song , Ye Jian Zhou , Luo Guang Yun , Li Bai Cheng , Gan Ning . . Journal of Kunming Medical University, 2019, 40(11): 13-20.
[8]	Li Jian Jiao , Dai Xiao Ming . A Study on Expression of Histone Deacetylase-2 in Humantongue Squamous Cell Carcinomas. Journal of Kunming Medical University, 2018, 39(08): 80-85.
[9]	Yuan Ying , Li Yuan Yuan , Guo Fang Yuan , Yang Hong Ying . D-dimer Monitoring and Application of Low Molecular Weight Heparin in Prevention of Venous Thrombotic Disease after Gynecological Operation. Journal of Kunming Medical University, 2017, 38(04): 109-112.
[10]	Zhang Fu Hou . Research Progress of Galectin in Mchanism of Venous Trombosis. Journal of Kunming Medical University,
[11]	Dong Zhong Li . Monocytes/Macrophages Promote Venous Thrombosis Organization and Recanalization：Mechanism and Research Progress. Journal of Kunming Medical University,
[12]	Liu De Hong , Shao Ju Wei , Xiang Shu Tian , Liu Chen , Wang Peng , Li Ying Wen . Comparison of BRAVO Sequence and TRICKS Sequence on Cerebral Venous Sinus Thrombosis. Journal of Kunming Medical University, 2016, 37(11): 121-125.
[13]	Fei Qiu Yue . . Journal of Kunming Medical University,
[14]	Dai Qing Yuan . . Journal of Kunming Medical University,
[15]	Geng Yu Liu . . Journal of Kunming Medical University,
[16]	Wen Wei . . Journal of Kunming Medical University,
[17]	Liu Jun . . Journal of Kunming Medical University,
[18]	Bu Rui . . Journal of Kunming Medical University,
[19]	. . Journal of Kunming Medical University,
[20]	. . Journal of Kunming Medical University,