Analysis of Monitoring Results and Influencing Factors of Vancomycin Blood Concentration in Neurosurgery Department

Juan LI; Jun ZHANG; Qiao-ling ZHENG; Pu-qiong FENG; Jin HE

doi:10.12259/j.issn.2095-610X.S20210614

Volume 42 Issue 6

Jul. 2021

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Article Navigation > Journal of Kunming Medical University > 2021 > 42(6): 110-114

Juan LI, Jun ZHANG, Qiao-ling ZHENG, Pu-qiong FENG, Jin HE. Analysis of Monitoring Results and Influencing Factors of Vancomycin Blood Concentration in Neurosurgery Department[J]. Journal of Kunming Medical University, 2021, 42(6): 110-114. doi: 10.12259/j.issn.2095-610X.S20210614

Citation:

Juan LI, Jun ZHANG, Qiao-ling ZHENG, Pu-qiong FENG, Jin HE. Analysis of Monitoring Results and Influencing Factors of Vancomycin Blood Concentration in Neurosurgery Department[J]. Journal of Kunming Medical University, 2021, 42(6): 110-114. doi: 10.12259/j.issn.2095-610X.S20210614

Citation:

Juan LI, Jun ZHANG, Qiao-ling ZHENG, Pu-qiong FENG, Jin HE. Analysis of Monitoring Results and Influencing Factors of Vancomycin Blood Concentration in Neurosurgery Department[J]. Journal of Kunming Medical University, 2021, 42(6): 110-114. doi: 10.12259/j.issn.2095-610X.S20210614

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Analysis of Monitoring Results and Influencing Factors of Vancomycin Blood Concentration in Neurosurgery Department

doi: 10.12259/j.issn.2095-610X.S20210614

Dept. of Clinical Pharmacy，The First Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032，China

Received Date: 2021-04-19
Available Online: 2021-07-09
Publish Date: 2021-07-21

Abstract

Abstract

Objective To provide reference for clinical rational use of vancomycin through analyzing the monitoring results of vancomycin plasma concentration in patients with intracranial infection or/and pulmonary infection after neurosurgery in our hospital. Methods We collected the related information of 119 neurosurgical patients with intracranial infection and/or pulmonary infection, and the monitoring results of vancomycin blood concentration and the influencing factors were analyzed. Results With the dosage of vancomycin 1g, IVGTT, q12h, only 26.1% of the patients were within the reference range （10-20 mg/L）and 68.1% were lower than the reference range. Multiple linear regression analysis showed that only creatinine clearance rate had significant effect on the trough concentration of vancomycin. Conclusion When patients with postoperative infection in neurosurgery are treated with vancomycin, the dosage of 1g, IVGTT, q12h may not reach the effective blood concentration, so the initial dosage should be selected according to the creatinine clearance rate of patients, and the blood concentration of vancomycin should be closely monitored, and the dosage regimen should be adjusted according to the situation of patients and the detection results timely.
- Neurosurgery,
- Vancomycin,
- Blood concentrations,
- Influence factor

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References(15)

References

[1]	KIM D H,HONG Y K,JEUN S S,et al. Is Coincidental Rhinosinusitis a Predisposing Factor for Postoperative Central Nervous System Infection After Endoscopic Endonasal Transsphenoidal Surgery?[J]. J Craniofac Surg,2018,29(3):e319-e322. doi: 10.1097/SCS.0000000000004443
[2]	LIU E W,SCHWARTZ B S,HYSMITH N D,et al. Rat Lungworm Infection Associated with Central Nervous System Disease - Eight U. S. States,January 2011-January 2017[J]. Mmwr Morb Mortal Wkly Rep,2018,67(30):825-828. doi: 10.15585/mmwr.mm6730a4
[3]	YOSHIMORI M,IMADOME K I,TOMII S,et al. [Cerebrospinal fluid findings in chronic active Epstein-Barr virus infection with central nervous system involvement][J]. Rinsho Ketsueki,2018,59(4):367-372.
[4]	李娜,乔逸,丁选胜,等. 利奈唑胺治疗神经外科术后颅内感染的疗效及安全性分析[J]. 中国药房,2018,29(10):1360-1363. doi: 10.6039/j.issn.1001-0408.2018.10.16
[5]	OH S J,HONG K S,LEE E J,et al. Assessment of therapeutic drug monitoring of vancomycin in elderly patients according to new guidelines[J]. ANN LAB MED,2014,34(1):1-6. doi: 10.3343/alm.2014.34.1.1
[6]	RYBAK M,LOMAESTRO B,ROTSCHAFER J C,et al. Therapeutic monitoring of vancomycin in adult patients:a consensus review of the American Society of Health-System Pharmacists,the Infectious Diseases Society of America,and the Society of Infectious Diseases Pharmacists[J]. Am J Health Syst Pharm,2009,66(1):82-98. doi: 10.2146/ajhp080434
[7]	BINGEN E,MARIANI-KURKDJIAN P,NEBBAD B. [Optimal vancomycin serum level in Staphylococcus aureus infections?][J]. Med Mal Infect,2006,36(9):439-442. doi: 10.1016/j.medmal.2006.07.016
[8]	黄仲义,肖永红,张菁,等. 万古霉素临床应用中国专家共识(2011版)[J]. 中国新药与临床杂志,2011,30(8):561-573.
[9]	申庆荣,李刚,卢秋玉,等. 万古霉素血药浓度的影响因素分析[J]. 中国抗生素杂志,2017,42(5):429-434. doi: 10.3969/j.issn.1001-8689.2017.05.021
[10]	刘婧,黄萍,周健,等. 重症患者万古霉素血药浓度监测结果分析及非遗传因素对药物浓度的影响[J]. 现代医院,2020,20(1):118-121. doi: 10.3969/j.issn.1671-332X.2020.01.033
[11]	周冉,张圣雨,王春艳,等. ICU使用万古霉素的患者发生肾功能亢进的危险因素分析[J]. 中国医院药学杂志,2020,40(24):2549-2552.
[12]	王法琴,杨飞. 万古霉素和利奈唑胺治疗儿童中枢神经系统感染研究进展[J]. 中国现代应用药学,2017,34(2):301-304.
[13]	蔡艳,张熙,权俊杰,等. 神经外科术后感染患者万古霉素脑脊液穿透率测定及相关因素分析[J]. 中华医院感染学杂志,2016,26(24):5628-5631.
[14]	孙继锋. 万古霉素鞘内持续泵入与腰大池持续引流治疗侧脑室术后颅内感染[J]. 中国实用神经疾病杂志,2016,19(7):128-129. doi: 10.3969/j.issn.1673-5110.2016.07.085
[15]	陈凯,王佳庆,武元星,等. 脑室内注射万古霉素治疗术后颅内感染的方法学及药代动力学研究[J]. 临床神经外科杂志,2014,11(6):435-439. doi: 10.3969/j.issn.1672-7770.2014.06.010

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