Volume 42 Issue 6
Jul.  2021
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Article Navigation >  Journal of Kunming Medical University  > 2021  >  42(6): 98-102
Linhai CONG, Yong TANG, Jiazhi YIN, Li DENG, Huifang GAO, Hongli FANG, Xin LI. Effect of MiR-26a-5p Regulating SLC26A4 to Ameliorate Hearing Loss in Deafness[J]. Journal of Kunming Medical University, 2023, 44(6): 14-18. doi: 10.12259/j.issn.2095-610X.S20230603
Citation: Fang WANG, Rong ZHAO, Hong ZHENG. Clinical Effect of Kan Fu Xin Combined with Montmorillonite on the Prevention and Treatment of Radiation-induced Oral Mucositis in Patients with Head and Neck Cancer[J]. Journal of Kunming Medical University, 2021, 42(6): 98-102. doi: 10.12259/j.issn.2095-610X.S20210626
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Clinical Effect of Kan Fu Xin Combined with Montmorillonite on the Prevention and Treatment of Radiation-induced Oral Mucositis in Patients with Head and Neck Cancer

doi: 10.12259/j.issn.2095-610X.S20210626

  • Dept. of Medical Oncology，The First People’s Hospital of Yunnan Province，Kunming Yunnan 650032，China

  • Received Date: 2021-03-08
    Available Online: 2021-07-09
  • Publish Date: 2021-07-21
    Abstract
  •   Objective  To observe the effect of Kan Fu Xin combined with Montmorillonite on the prevention and treatment of radiation-induced oral mucositis in patients with Head and Neck Cancer.  Methods  In this trial, we included 138 patients with head and neck cancer who underwent radiotherapy from the First People’ s Hospital of Yunnan Province from April 2018 to February 2019, which were randomly divided into the experimental group （69 cases） and the control group （69 cases）. The control group received routine care and symptomatic treatment. The experimental group gave Kan Fu Xin combined with Montmorillonite protection on the basis of routine care, and adjusted 1 bag of Montmorillonite and appropriate amount of Kan Fu Xin fluid into a paste. Then contained in the mouth for 5 minutes before each radiotherapy and before going to bed. We observed the degree of radiation-induced oral mucositis damage, the degree of oral radiation pain, the completion time of radiotherapy and recovery, etc.  Results  We found that the experimental group had a late onset of radiation-induced oral mucositis and a shorter recovery time than the control group （P < 0.05）. At the 3rd and 4th week of radiotherapy, the RTOM of the experimental group was mainly mild to moderate, and the control group was mainly moderate and severe. At the 5th and 6th week, the RTOM of the experimental group was mainly moderate, and the control group was mainly severe. At the 3rd to 6th week, there was a statistically significant difference in the incidence of RTOM between the two groups （P < 0.01）. The average radiotherapy time of the experimental group was less than that of the control group, and the difference was statistically significant （P < 0.05）.  Conclusion  Kan Fun Xin combined Montmorillonite can significantly reduce the symptoms of patients with radioactive oral mucositis, ensure that radiotherapy is completed on time, and can be widely used in clinical.
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