Sevoflurane Inhibits Xuanwei Lung Cancer Cell Line XWLC-05

Yu-hang QUAN; Zhong-hui WANG; Shan-shan LI; Guang-shun LIU

doi:10.12259/j.issn.2095-610X.S20211202

Volume 42 Issue 12

Dec. 2021

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Yu-hang QUAN, Zhong-hui WANG, Shan-shan LI, Guang-shun LIU. Sevoflurane Inhibits Xuanwei Lung Cancer Cell Line XWLC-05[J]. Journal of Kunming Medical University, 2021, 42(12): 1-5. doi: 10.12259/j.issn.2095-610X.S20211202

Citation:

Yu-hang QUAN, Zhong-hui WANG, Shan-shan LI, Guang-shun LIU. Sevoflurane Inhibits Xuanwei Lung Cancer Cell Line XWLC-05[J]. Journal of Kunming Medical University, 2021, 42(12): 1-5. doi: 10.12259/j.issn.2095-610X.S20211202

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Sevoflurane Inhibits Xuanwei Lung Cancer Cell Line XWLC-05

doi: 10.12259/j.issn.2095-610X.S20211202

Dept. of Anesthesiology ，The 3rd Affiliated Hospital of Kunming Medical University/Cancer Hospital of Yunnan Province，Kunming Yunnan 650118，China

Received Date: 2021-10-05
Available Online: 2021-11-16
Publish Date: 2021-12-15

Abstract

Abstract

Objective To investigate the effects of sevoflurane on proliferation, migration, invasion and malignant behavior of Xuanwei lung cancer cells XWLC-05, and to further explore its potential mechanism. Method XWLC-05 cells were treated with sevoflurane, and the changes of proliferation, apoptosis, migration and invasion of XWLC-05 cells were detected in vitro; the tumorigenicity of XWLC-05 cells was detected in vivo, and the expressions of PI3K/AKT and MMP-2 / MMP-9 were analyzed by Western blot. Result The number of clones in control group （287.5±23.1） was higher than that in experimental group （174.1±16.3）（P < 0.05）; the apoptosis rate in the control group （1.60±0.38） was significantly lower than that in the experimental group （31.48±5.81）（P < 0.01）, and the number of migrating cells in the control group （87.8±10.2） was significantly higher than that in the experimental group （35.2±4.4）（P < 0.05）. The number of invasive cells in the control group（93.6±7.3） was significantly higher than that in the experimental group （30.7±3.2）（P < 0.01）. Sevoflurane treatment significantly decreased the expression levels of PI3K, p-Akt and MMP-2, MMP-9 （P < 0.05）. Conclusion By inhibiting PI3K/AKT signaling pathway, sevoflurane decreased the proliferation ability of XWLC-05, induced apoptosis, and weakened the migration, invasion and tumorigenesis ability of XWLC-05 cells. Sevoflurane may be a new treatment option for Xuanwei lung cancer.
- Sevoflurane,
- Xuanwei lung cancer,
- Apoptosis,
- Cell proliferation

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References(25)

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