Application of Thyroid Function in 10-year Cardiovascular Disease Risk Assessment of T2DM

Pei-qi CHEN; Zong-lu YANG; Ling ZHAO; Shi-gang DU; Lu YANG; Shi-yu Li; Yu-ru DAI; Ting-yu KE

doi:10.12259/j.issn.2095-610X.S20211215

Volume 42 Issue 12

Dec. 2021

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Article Navigation > Journal of Kunming Medical University > 2021 > 42(12): 28-35

Pei-qi CHEN, Zong-lu YANG, Ling ZHAO, Shi-gang DU, Lu YANG, Shi-yu Li, Yu-ru DAI, Ting-yu KE. Application of Thyroid Function in 10-year Cardiovascular Disease Risk Assessment of T2DM[J]. Journal of Kunming Medical University, 2021, 42(12): 28-35. doi: 10.12259/j.issn.2095-610X.S20211215

Citation:

Pei-qi CHEN, Zong-lu YANG, Ling ZHAO, Shi-gang DU, Lu YANG, Shi-yu Li, Yu-ru DAI, Ting-yu KE. Application of Thyroid Function in 10-year Cardiovascular Disease Risk Assessment of T2DM[J]. Journal of Kunming Medical University, 2021, 42(12): 28-35. doi: 10.12259/j.issn.2095-610X.S20211215

Citation:

Pei-qi CHEN, Zong-lu YANG, Ling ZHAO, Shi-gang DU, Lu YANG, Shi-yu Li, Yu-ru DAI, Ting-yu KE. Application of Thyroid Function in 10-year Cardiovascular Disease Risk Assessment of T2DM[J]. Journal of Kunming Medical University, 2021, 42(12): 28-35. doi: 10.12259/j.issn.2095-610X.S20211215

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Application of Thyroid Function in 10-year Cardiovascular Disease Risk Assessment of T2DM

doi: 10.12259/j.issn.2095-610X.S20211215

Dept. of Endocrinology，The 2nd Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650101，China

Received Date: 2021-10-18
Available Online: 2021-11-24
Publish Date: 2021-12-15

Abstract

Abstract

Objective To investigate the relationship between thyroid function and cardiovascular disease-related indicators, and explore feasibility of thyroid function in the risk assessment of cardiovascular disease and death in T2DM patients in the next 10 years. Methods A retrospective study was performed on 527 inpatients who met the diagnostic criteria for type 2 diabetes in the Department of Endocrinology, The Second Affiliated Hospital of Kunming Medical University from January 2018 to December 2020. Among them, 100 patients with type 2 diabetes complicated with subclinical hypothyroidism without previous history of valvular heart disease or myocardial infarction were enrolled as case group （DM+SCH group）; 100 patients with normal thyroid function without previous history of valvular heart disease or myocardial infarction were stratified and randomly selected from the 527 patients with type 2 diabetes as control group （DM group）. Data of basic characteristics, blood chemistry and imaging of all patients were collected, and comparison between groups was conducted. Pearson correlation analysis was used to analyze the levels of thyroid stimulating hormone and blood lipids such as total cholesterol （TC） and Triacyl triglycerol （TG）, respectively. Cardiac function indicators include left ventricular ejection fraction （LVEF）, cardiac output （CO）, cardiac index （Cardiac index）. CI） and ratio of early and late mitral valve diastolic filling speed （E/A ratio） were collected to evaluate the correlation between thyroid function and cardiovascular disease related indicators. Results There were 100 patients with subclinical hypothyroidism among all the patients in this study, the prevalence rate is 18.98%.The female cases in DM+SCH group were significantly higher than DM group, the difference was statistically significant （P < 0.05）. Compared with DM group, TSH level in DM+SCH group was significantly higher, TT3, FT3, TT4, FT4 and RT3 levels were decreased, and TG-AB level was significantly higher, with statistical significance （P < 0.05, P < 0.01）. The serum levels of TC, LDL-C and LDL-C/HDL-C in DM+SCH group were higher than those in DM group, and the differences were statistically significant （P < 0.01）. In DM+SCH group, CO, LVEF, E peak, E/A ratio decreased, and vascular resistance increased, with statistically significant difference（P < 0.05, P < 0.01）. Pearson correlation analysis showed that TC and LDL-C levels were positively correlated with TSH levels （P < 0.05, P < 0.01）. CO, LVEF, E peak and E/A were negatively correlated with TSH level （P < 0.05, P < 0.01）, while vascular resistance was positively correlated with TSH level （P < 0.05）. Conclusions 1. TSH is associated with lipid profile and partial cardiac function in type 2 diabetes mellitus with subclinical hypothyroidism. 2. Thyroid function should be included in the assessment of the occurrence and mortality risk of cardiovascular disease in patients with type 2 diabetes over the next 10 years.
- Type 2 diabetes,
- Cardiovascular disease,
- Risk assessment,
- Subclinical hypothyroidism

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References(19)

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