Assessment of Early Coronary Artery Disease in Patients with Acute Coronary Syndrome

Juan ZHAO; Teng-can TU; Mei-jun YANG; Xiao-yong ZHANG; Wei PAN

doi:10.12259/j.issn.2095-610X.S20211219

Volume 42 Issue 12

Dec. 2021

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Article Navigation > Journal of Kunming Medical University > 2021 > 42(12): 47-50

Juan ZHAO, Teng-can TU, Mei-jun YANG, Xiao-yong ZHANG, Wei PAN. Assessment of Early Coronary Artery Disease in Patients with Acute Coronary Syndrome[J]. Journal of Kunming Medical University, 2021, 42(12): 47-50. doi: 10.12259/j.issn.2095-610X.S20211219

Citation:

Juan ZHAO, Teng-can TU, Mei-jun YANG, Xiao-yong ZHANG, Wei PAN. Assessment of Early Coronary Artery Disease in Patients with Acute Coronary Syndrome[J]. Journal of Kunming Medical University, 2021, 42(12): 47-50. doi: 10.12259/j.issn.2095-610X.S20211219

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Assessment of Early Coronary Artery Disease in Patients with Acute Coronary Syndrome

doi: 10.12259/j.issn.2095-610X.S20211219

1.
Dept. of Ultrasound
2.
Dept. of Cardiovascular，The 6th Affiliated Hospital，South China University of Technology，Nanhai People Hospital，Foshan Guangdong 528200
3.
Dept. of Pharmacy，Lincang People’s Hospital，Lincang Yunnan 677000
4.
Dept. of Cardiovascular，The Affiliated Yan’an Hospital of Kunming Medical University，Kunming Yunnan 650051，China

Received Date: 2021-09-05
Available Online: 2021-11-17
Publish Date: 2021-12-15

Abstract

Abstract

Objective To investigate the role of plasma miR-30a and coronary intravascular ultrasound （IVUS） in the early assessment of coronary artery disease in patients with acute coronary syndrome （ACS）. Methods 88 ACS patients were randomly selected, including stable angina group （SA group, 42 cases） and ACS group （46 cases）. Plaque load and remodeling index （RI） were detected by IVUS, and plasma miR-30a was detected by real-time PCR. The changes of plaque load, RI and plasma miR-30a in ACS group were studied. The relationship between plaque load, plasma miR-30a and RI was analyzed by Pearson correlation. Plaque load and remodeling index （RI） were detected by IVUS, and plasma miR-30a was detected by real-time PCR. The changes of plaque load, RI and plasma miR-30a in ACS group were studied. The relationship between plaque load, plasma miR-30a and RI was analyzed by Pearson correlation. Results Compared with SA group, plaque load in ACS group was increased [ （62.82±4.40）% vs （68.32±4.59）%]; RI increased from （0.90±0.03） to （1.15±0.05）; plasma miR-30a[ （8.10±1.09）2^-ΔΔct*10⁴ vs （11.66±1.19）2^-ΔΔct*10⁴] increased. RI was positively correlated with plaque load （r = 0.482, P = 0.000） and plasma miR-30a level （r = 0.817, P = 0.000）. Conclusion Patients with ACS have early coronary artery positive remodeling, and plasma miR-30a can be used as an evaluation indicator of early ACS coronary artery disease.
- Echocardiography,
- microRNAs,
- Acute coronary syndrome,
- Vascular remodeling

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References(16)

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