Volume 43 Issue 4
Apr.  2022
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Yegang HU, Wei ZHANG. Role of Hereditary T Lymphocyte Immune Deficiency in Pulmonary Fibrosis Induced by Paraquat[J]. Journal of Kunming Medical University, 2022, 43(4): 6-11. doi: 10.12259/j.issn.2095-610X.S20220402
Citation: Yegang HU, Wei ZHANG. Role of Hereditary T Lymphocyte Immune Deficiency in Pulmonary Fibrosis Induced by Paraquat[J]. Journal of Kunming Medical University, 2022, 43(4): 6-11. doi: 10.12259/j.issn.2095-610X.S20220402
shu

Role of Hereditary T Lymphocyte Immune Deficiency in Pulmonary Fibrosis Induced by Paraquat

doi: 10.12259/j.issn.2095-610X.S20220402

  • Dept. of Critical Care Medicine，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032，China

  • Received Date: 2022-02-28
    Available Online: 2022-03-23
  • Publish Date: 2022-04-25
    Abstract
  •   Objective  To study the role of T lymphocyte immune deficiency in pulmonary fibrosis induced by paraquat.   Methods  BALB/C （nu/nu） nude mice and BALB/C （nu/+） mice were selected as experimental animal models. Paraquat was given 20 mg/kg by intragastric administration and paraquat concentration in plasma was determined by GC-MS 1 hour after administration. Lung tissues were obtained for pathological sections on the 7th and 28th day after administration by H&E and MASSON staining.  Results  There was no significant difference in plasma paraquat concentration of 2 strains of mice after 1 hour of exposure （P > 0.05） . H&E and MASSON staining of pathological sections on day 28th showed that there was statistical difference in the degree of fibrosis between the two strains （P < 0.05）.  Conclusion  T lymphocyte is involved in the pulmonary fibrosis caused by paraquat, but the loss of T lymphocytes does not completely avoid pulmonary fibrosis induced by paraquat. T lymphocyte immune deficiency is not the decisive factor of pulmonary fibrosis induced by paraquat.
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