Clinical Evaluation of Immune Function and SAA, MMP-9 and MMP-14 in Liver Injury Caused by Anti-Tuberculous Drugs

Nihong LU; Honglu LIU; Jiawei XIA; Yangjun CHEN; Linjun SHEN; Yongrui YANG; Jie LI

doi:10.12259/j.issn.2095-610X.S20220410

Volume 43 Issue 4

Apr. 2022

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Nihong LU, Honglu LIU, Jiawei XIA, Yangjun CHEN, Linjun SHEN, Yongrui YANG, Jie LI. Clinical Evaluation of Immune Function and SAA, MMP-9 and MMP-14 in Liver Injury Caused by Anti-Tuberculous Drugs[J]. Journal of Kunming Medical University, 2022, 43(4): 50-54. doi: 10.12259/j.issn.2095-610X.S20220410

Citation:

Nihong LU, Honglu LIU, Jiawei XIA, Yangjun CHEN, Linjun SHEN, Yongrui YANG, Jie LI. Clinical Evaluation of Immune Function and SAA, MMP-9 and MMP-14 in Liver Injury Caused by Anti-Tuberculous Drugs[J]. Journal of Kunming Medical University, 2022, 43(4): 50-54. doi: 10.12259/j.issn.2095-610X.S20220410

Citation:

Nihong LU, Honglu LIU, Jiawei XIA, Yangjun CHEN, Linjun SHEN, Yongrui YANG, Jie LI. Clinical Evaluation of Immune Function and SAA, MMP-9 and MMP-14 in Liver Injury Caused by Anti-Tuberculous Drugs[J]. Journal of Kunming Medical University, 2022, 43(4): 50-54. doi: 10.12259/j.issn.2095-610X.S20220410

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Clinical Evaluation of Immune Function and SAA, MMP-9 and MMP-14 in Liver Injury Caused by Anti-Tuberculous Drugs

doi: 10.12259/j.issn.2095-610X.S20220410

1.
Dept. of Respiratory and Critical Care Medicine
2.
Yunnan Provincial Clinical Medical Center for Infectious Diseases
3.
Dept. of Tuberculosis
4.
Dept. of Hepatology
5.
Medical examination center，Kunming Third People’s Hospital，Yunnan Province，Kunming Yunnan 650041，China

Received Date: 2022-01-01
Available Online: 2022-03-15
Publish Date: 2022-04-25

Abstract

Abstract

Objective To explore the changes of immune function in patients with anti-tuberculous drug-induced liver injury （ATB-DILI）, and to explore the clinical value and application significance of serum amylase A （SAA）, matrix metalloproteinase 9 （MMP-9） and matrix metalloproteinase 14 （MMP-14） in anti-tuberculosis drug liver injury. Methods A total of 115 patients with anti-tuberculosis drug-induced liver injury admitted to the Third People’ s Hospital of Kunming from July 2019 to July 2020 were selected. Based on types of liver injury, the patients were divided into 4 subgroups A, B, C and D, and 35 healthy subjects underwent health check during the same period were selected as control group （group E）. The changes and expression levels of immune function, SAA, MMP-9 and MMP-14 in different subgroups were compared, as well as their relationship with ATB-DILI severity grade. Results The CD4⁺ count of group A patients was lower than that of group E, and the difference was statistically significant （P < 0.05）. The expression levels of SAA and MMP-9 in gronp A were higher than the other three groups, and the difference between the groups was statistically significant （P < 0.05）. The expression of MMP-14 in group C was higher than that of the other three groups, and the difference was statistically significant （P < 0.05）. SAA and MMP-9 were correlated with the severity of anti-tuberculosis drug liver injury （r = 0.687, P < 0.05; r = 0.811, P < 0.05）. Conclusion CD4⁺ counts were reduced in some patients with ATB-DILI, suggesting that these patients have low immune function, and the impaired immune function may be related to liver injury. SAA, MMP-9 and MMP-14 increased in different degrees in patients with different types of anti-tuberculosis drug liver injury. The severity of liver injury is closely related to the expression of SAA and MMP-9. SAA, MMP-9 and MMP-14 are expected to be the evaluation indicators of the severity of clinical ATB-DILI.
- Immune function,
- Serum amyloid A,
- Matrix mctalloprotcinase-9,
- Matrix mctalloprotcinase-14,
- Anti-tuberculosis drug-induced liver injury,
- Evaluation value

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