Diagnostic Value of Combined Detection of Serum GAD，ICA and C-P in Type I Diabetes Mellitus

Yan JIANG; Zhengke ZHAO; Guangyan WANG; Liangang XU; Mengdie LI; Maofan WANG; Shuangmei LONG; Jiao LIU; Jin QIAN

doi:10.12259/j.issn.2095-610X.S20220416

Volume 43 Issue 4

Apr. 2022

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Yan JIANG, Zhengke ZHAO, Guangyan WANG, Liangang XU, Mengdie LI, Maofan WANG, Shuangmei LONG, Jiao LIU, Jin QIAN. Diagnostic Value of Combined Detection of Serum GAD，ICA and C-P in Type I Diabetes Mellitus[J]. Journal of Kunming Medical University, 2022, 43(4): 99-102. doi: 10.12259/j.issn.2095-610X.S20220416

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Diagnostic Value of Combined Detection of Serum GAD，ICA and C-P in Type I Diabetes Mellitus

doi: 10.12259/j.issn.2095-610X.S20220416

1.
Dept. of Clinical laboratory
2.
Dept. of Science and Education，Chuxiong Yi Autonomous Perfecture People’s Hospital，Chuxiong Yunnan 675000，China

Received Date: 2022-01-01
Publish Date: 2022-04-25

Abstract

Abstract

Objective To explore the diagnostic value of glutamic acid decarboxylase antibody （GAD）, islet cell autoantibody （ICA） and C-Peptide （C-P） detection in Type I diabetes mellitus. Methods GAD, ICA and C-P values of 54 T1DM confirmed patients in People’ s Hospital of Chuxiong Yi Autonomous Prefecture from January 2019 to August 2020 were analyzed retrospectively, and compared with 50 normal people who came to our hospital for physical examination during this period. Results GAD and ICA in observation group were significantly higher than those in control group. The C-P of observation group was significantly lower than that of control group, and the difference was statistically significant （P < 0.05）. The AUC of GAD, ICA, C-P and three combined tests for T1DM diagnosis were 0.927, 0.840, 0.956 and 0.993, respectively. The area under ROC curve （AUC） of GAD, ICA and C-P combined detection was the largest, suggesting that the diagnostic efficiency of GAD, ICA and C-P combined detection was higher than that of GAD, ICA and C-P alone. Conclusion The combined detection of GAD, ICA and C-P can improve the sensitivity and specificity of T1DM diagnosis, and play an outstanding role in the early diagnosis, treatment, prevention and early warning evaluation of T1DM.
- Type 1 diabetes mellitus,
- Glutamic acid decarboxylase antibody,
- Islet cell autoantibody,
- C-P

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References(15)

References

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