Volume 43 Issue 4
Apr.  2022
Turn off MathJax
Article Contents
Abstract
References
Relative Articles
Article Navigation >  Journal of Kunming Medical University  > 2022  >  43(4): 152-157
Xiaojie CHEN, Xingrao WU, Shuhui YU, Zheng LI, Lan ZHANG. Advances on HBV Infection in the Occurrence and Development of Gynecologic Malignancies[J]. Journal of Kunming Medical University, 2022, 43(4): 152-157. doi: 10.12259/j.issn.2095-610X.S20220424
Citation: Xiaojie CHEN, Xingrao WU, Shuhui YU, Zheng LI, Lan ZHANG. Advances on HBV Infection in the Occurrence and Development of Gynecologic Malignancies[J]. Journal of Kunming Medical University, 2022, 43(4): 152-157. doi: 10.12259/j.issn.2095-610X.S20220424
shu

Advances on HBV Infection in the Occurrence and Development of Gynecologic Malignancies

doi: 10.12259/j.issn.2095-610X.S20220424
  • 1.

    Dept. of Pharmacy，Yanshi Traditional Chinese Medicine Hospital，Luoyang Henan 471900

  • 2.

    Dept. of Radiotherapy，Yunnan Cancer Hospital，The 3rd Affiliated Hospital of Kunming Medical University

  • 3.

    Dept. of Gynecologic Oncology，Yunnan Cancer Hospital，The 3rd Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650118，China

  • Received Date: 2022-02-23
  • Publish Date: 2022-04-25
    Abstract
  • The incidence of human cancers attributable to infectious agents has been estimated to be 15%. Hepatitis B virus（HBV） infects hepatocytes causing hepatocellular carcinoma. It can also infect extrahepatic cells and cause chronic inflammation, which is associated with a variety of extrahepatic cancers. Female reproductive organs communicate with the external environment through vagina. Viral nucleic acid can be detected in the vaginal secretions and ovarian tissues of HBV carriers. Epidemiological studies suggested HBV infection may be a risk factor for gynecologic malignancies, and related to poor prognosis of patients. Cervical cancer, endometrial cancer and ovarian cancer are most common gynecologic malignancies. This paper reviews the recent studies on the association between HBV infection and gynecologic malignancies, and analyzes the potential mechanism of HBV infection in the occurrence and development of cancer and prospects the future research direction.
    • FullText(HTML)
    • References(42)
  • [1]
    Ruan B,Yu Z,Yang S,et al. Establishment and development of national community-based collaborative innovation demonstration areas to achieve the control target of hepatitis B in China[J]. BMC Infectious Diseases,2019,19(1):617. doi: 10.1186/s12879-019-4150-9
    [2]
    El-Serag H B. Epidemiology of viral hepatitis and hepatocellular carcinoma[J]. Gastroenterology,2012,142(6):1264-1273. doi: 10.1053/j.gastro.2011.12.061
    [3]
    Dalia S,Chavez J,Castillo J J,et al. Hepatitis B infection increases the risk of non-Hodgkin lymphoma:A meta-analysis of observational studies[J]. Leukemia Research,2013,37(9):1107-1115. doi: 10.1016/j.leukres.2013.06.007
    [4]
    Hassan M M,Li D,El-Deeb A S,et al. Association between hepatitis B virus and pancreatic cancer[J]. Journal of Clinical Oncology,2008,26(28):4557-4562. doi: 10.1200/JCO.2008.17.3526
    [5]
    Hsing A W,Zhang M,Rashid A,et al. Hepatitis B and C virus infection and the risk of biliary tract cancer:A population-based study in China[J]. International Journal of Cancer,2008,122(8):1849-1853.
    [6]
    Wei X L,Qiu M Z,Jin Y,et al. Hepatitis B virus infection is associated with gastric cancer in China:An endemic area of both diseases[J]. British Journal of Cancer,2015,112(7):1283-1290. doi: 10.1038/bjc.2014.406
    [7]
    Ye Y F,Xiang Y Q,Fang F,et al. Hepatitis B virus infection and risk of nasopharyngeal carcinoma in southern China[J]. Cancer Epidemiology,Biomarkers & Prevention,2015,24(11):1766-1773.
    [8]
    Wei X L,Luo H Y,Li C F,et al. Hepatitis B virus infection is associated with younger median age at diagnosis and death in cancers[J]. International Journal of Cancer,2017,141(1):152-159. doi: 10.1002/ijc.30719
    [9]
    Bozza C,Cinausero M,Iacono D,et al. Hepatitis B and cancer:A practical guide for the oncologist[J]. Critical Reviews in Oncology Hematology,2016,98:137-146. doi: 10.1016/j.critrevonc.2015.10.017
    [10]
    Dimond C,Negroiu A,D M H,Patel J. Fatal hepatitis B reactivation in a patient receiving chemoradiation for cervical cancer[J]. Journal of Oncology Pharmacy Practice,2021,27(5):1296-1301. doi: 10.1177/1078155220964256
    [11]
    Zhang X,Zhou Y,Chen C,et al. Hepatitis B virus reactivation in cancer patients with positive hepatitis B surface antigen undergoing PD-1 inhibition[J]. Journal for Immunotherapy of Cancer,2019,7(1):322. doi: 10.1186/s40425-019-0808-5
    [12]
    Galun E,Ilan Y,Livni N,et al. Hepatitis B virus infection associated with hematopoietic tumors[J]. American Journal of Pathology,1994,145(5):1001-1007.
    [13]
    刘北陆,栾建兵. 乙型病毒性肝炎与宫颈癌相关性分析[J]. 现代检验医学杂志,2008,5(23):60-62.
    [14]
    An J,Kim J W,Shim J H,et al. Chronic hepatitis B infection and non-hepatocellular cancers:A hospital registry-based,case-control study[J]. PLoS One,2018,13(3):0193232.
    [15]
    Siu S S,Cheung T H,Chan P K,et al. Patients with malignant or pre-malignant cervical lesion have increased risk of becoming hepatitis B carrier[J]. Journal of Experimental & Clinical Cancer Research,2007,26(1):77-81.
    [16]
    Song C,Lv J,Liu Y,et al. Associations between hepatitis B virus infection and risk of all cancer types[J]. JAMA Network Open,2019,2(6):195718. doi: 10.1001/jamanetworkopen.2019.5718
    [17]
    Kamiza A B,Su F H,Wang W C,et al. Chronic hepatitis infection is associated with extrahepatic cancer development:A nationwide population-based study in Taiwan[J]. BMC Cancer,2016,16(1):861. doi: 10.1186/s12885-016-2918-5
    [18]
    Sundquist K,Sundquist J,Ji J. Risk of hepatocellular carcinoma and cancers at other sites among patients diagnosed with chronic hepatitis B virus infection in sweden[J]. Journal of Medical Virology,2014,86(1):18-22. doi: 10.1002/jmv.23754
    [19]
    Mahale P,Engels E A,Koshiol J. Hepatitis B virus infection and the risk of cancer in the elderly US population[J]. International Journal of Cancer,2019,144(3):431-439. doi: 10.1002/ijc.31643
    [20]
    Jiang X F,Tang Q L,Zou Y,et al. Does HBV infection increase risk of endometrial carcinoma?[J]. Asian Pacific Journal of Cancer Prevention,2014,15(2):713-716. doi: 10.7314/APJCP.2014.15.2.713
    [21]
    Lin H W,Tu Y Y,Lin S Y,et al. Risk of ovarian cancer in women with pelvic inflammatory disease:A population-based study[J]. Lancet Oncology,2011,12(9):900-904. doi: 10.1016/S1470-2045(11)70165-6
    [22]
    Ye F,Yue Y,Li S,et al. Presence of HBsAg,HBcAg,and HBVDNA in ovary and ovum of the patients with chronic hepatitis B virus infection[J]. American Journal of Obstetrics & Gynecology,2006,194(2):387-392.
    [23]
    Wong L,Cheung T H,Yim S F,et al. Prevalence and impact of hepatitis B virus infection in ovarian cancer patients in an endemic area-A retrospective cohort study[J]. Journal of Viral Hepatitis,2020,27(5):520-525. doi: 10.1111/jvh.13250
    [24]
    Zou J,Chen J,Xie X,et al. Hepatitis B virus infection is a prognostic biomarker for better survival in operable esophageal cancer:Analysis of 2,004 patients from an endemic area in China[J]. Cancer Epidemiology,Biomarkers & Prevention,2019,28(6):1028-1035.
    [25]
    Lu T,Yang Q,Li M,et al. HBV infection and extra-hepatic cancers in adolescents and 20s:A retrospective study in China[J]. Cancer Epidemiology,2018,55:149-155. doi: 10.1016/j.canep.2018.05.012
    [26]
    Michalak T I,Pardoe I U,Coffin C S,et al. Occult lifelong persistence of infectious hepadnavirus and residual liver inflammation in woodchucks convalescent from acute viral hepatitis[J]. Hepatology,1999,29(3):928-938. doi: 10.1002/hep.510290329
    [27]
    Mason A,Wick M,White H,et al. Hepatitis B virus replication in diverse cell types during chronic hepatitis B virus infection[J]. Hepatology,1993,18(4):781-789. doi: 10.1002/hep.1840180406
    [28]
    Leung N W,Tam J S,Lau G T,et al. Hepatitis B virus DNA in peripheral blood leukocytes. A comparison between hepatocellular carcinoma and other hepatitis B virus-related chronic liver diseases[J]. Cancer,1994,73(4):1143-1148. doi: 10.1002/1097-0142(19940215)73:4<1143::AID-CNCR2820730404>3.0.CO;2-U
    [29]
    Zhang S L,Yue Y F,Bai G Q,et al. Mechanism of intrauterine infection of hepatitis B virus[J]. World Journal of Gastroenterology,2004,10(3):437-438. doi: 10.3748/wjg.v10.i3.437
    [30]
    Tan Y J. Hepatitis B virus infection and the risk of hepatocellular carcinoma[J]. World Journal of Gastroenterology,2011,17(44):4853-4857. doi: 10.3748/wjg.v17.i44.4853
    [31]
    Li M,Sun X H,Zhu X J,et al. HBcAg induces PD-1 upregulation on CD4+T cells through activation of JNK,ERK and PI3K/AKT pathways in chronic hepatitis-B-infected patients[J]. Laboratory Investigation,2012,92(2):295-304. doi: 10.1038/labinvest.2011.157
    [32]
    Oliviero B,Cerino A,Varchetta S,et al. Enhanced B-cell differentiation and reduced proliferative capacity in chronic hepatitis C and chronic hepatitis B virus infections[J]. Journal of Hepatology,2011,55(1):53-60. doi: 10.1016/j.jhep.2010.10.016
    [33]
    叶丽虹,张伟英,靳天志,等. 乙肝病毒X蛋白结合蛋白在肿瘤发生发展中的作用[J]. 中国科学:生命科学,2019,49(9):1086-1099.
    [34]
    Li N,Wang Y,Che S,et al. HBXIP over expression as an independent biomarker for cervical cancer[J]. Experimental and Molecular Pathology,2017,102(1):133-137. doi: 10.1016/j.yexmp.2017.01.009
    [35]
    李巍巍. HBXIP及KLK7作为子宫恶性肿瘤预后和治疗评估的分子标志物的研究 [D]. 沈阳, 中国医科大学博士学位论文, 2018.
    [36]
    Wang Y,Sun J,Li N,et al. HBXIP overexpression is correlated with the clinical features and survival outcome of ovarian cancer[J]. Journal of Ovarian Research,2017,10(1):26-26. doi: 10.1186/s13048-017-0322-7
    [37]
    Xu F,Zhu X,Han T,et al. The oncoprotein hepatitis B X-interacting protein promotes the migration of ovarian cancer cells through the upregulation of S-phase kinase-associated protein 2 by Sp1[J]. International Journal of Oncology,2014,45(1):255-263. doi: 10.3892/ijo.2014.2411
    [38]
    Zou W,Ma X,Yang H,et al. Hepatitis B X-interacting protein promotes cisplatin resistance and regulates CD147 via Sp1 in ovarian cancer[J]. Experimental Biology and Medicine (Maywood),2017,242(5):497-504. doi: 10.1177/1535370216685007
    [39]
    中华医学会感染病学分会,中华医学会肝病学分会. 慢性乙型肝炎防治指南(2019年版)[J]. 中华传染病杂志,2019,12(37):711-736.
    [40]
    赵丽君,李娜,李琦,等. 化疗对妇科恶性肿瘤合并乙肝病毒携带者的影响(附26例临床分析)[J]. 现代妇产科进展,2013,10(22):796-799.
    [41]
    蒋凤莲,施为建,栾峰,等. HBsAg(-)伴HBcAb(+)妇科肿瘤患者TP化疗方案化疗后乙肝病毒再激活的临床研究[J]. 中国现代医生,2016,54(12):81-84.
    [42]
    Kotake T,Satake H,Okita Y,et al. Prevalence and risk factors of hepatitis B virus reactivation in patients with solid tumors with resolved HBV infection[J]. Asia Pacific Journal of Clinical Oncology,2019,15(1):63-68. doi: 10.1111/ajco.13050
    • Relative Articles(20)

  • Relative Articles

    [1] Qian AI, Zhirong ZHAO, Yue WU, Haiwen LI, Shenghao LI, Yongrui YANG. Analysis of Antiviral Efficacy and Safety in Patients with Chronic Hepatitis B in Indeterminate Phase. Journal of Kunming Medical University, 2025, 46(1): 51-59.  doi: 10.12259/j.issn.2095-610X.S20250107
    [2] Aiyun WANG, Yuting WANG, Jing CAI, Ruoyan NI, Caiying LUO, Zhuo YU, Peng CHEN. The Role of Intestinal Flora and Its Metabolites in The Development of Atherosclerosis. Journal of Kunming Medical University, 2024, 45(12): 160-166.  doi: 10.12259/j.issn.2095-610X.S20241223
    [3] Yu HUO, Yunhe JU, Yutao WANG, Yalin ZENG, Junfeng LIANG. The Role of DDX46 in the Occurrence And Development of Malignant Tumors. Journal of Kunming Medical University, 2024, 45(11): 161-165.  doi: 10.12259/j.issn.2095-610X.S20241123
    [4] Xiaoyan WANG, Ya LI, Chenglu HE, Lin WANG, Zhiqiang MA, Xinrui WAN. Study on Immune Function and Drug Resistance of Tuberculosis Patients Co-infected with HBV，HCV and HIV in Yunnan. Journal of Kunming Medical University, 2023, 44(12): 51-58.  doi: 10.12259/j.issn.2095-610X.S20231209
    [5] Dong PU, Tingting YU, Lihua LI, Runwu ZHANG, Kunli WU, Dongling LI. Analysis of Serum High-sensitivity HBV DNA in Patients with Chronic Hepatitis B with Low Viral Load in Kunming Area. Journal of Kunming Medical University, 2023, 44(1): 116-121.  doi: 10.12259/j.issn.2095-610X.S20230114
    [6] Qiao LUO, Hong SHI, Shaobo WANG. Role of α7-nicotinic Acetylcholine Receptor in Occurrence，Development and Therapy of Lung Cancer. Journal of Kunming Medical University, 2022, 43(2): 145-149.  doi: 10.12259/j.issn.2095-610X.S20220226
    [7] Jia-dai TANG, Lin XIE, Hong-li SONG, Jiao-jiao CHEN. Correlation between Metabolic Syndrome and the Occurrence and Development of Gastric Cancer. Journal of Kunming Medical University, 2021, 42(11): 171-175.  doi: 10.12259/j.issn.2095-610X.S20211130
    [8] Sheng-hao LI, Jie DING, Qing-qing WANG, Si-qi LIU, Li-juan HUA, Jin-yu DUAN, Bao-li BO, An-rui DU, Guo-ji CHANG, Jun-yi LI. Influencing Factors of Moderate to Severe Liver Injury in Patients with Chronic Hepatitis B and NAFLD. Journal of Kunming Medical University, 2021, 42(7): 77-82.  doi: 10.12259/j.issn.2095-610X.S20210712
    [9] Song-qin LV, Xi-ruo SUN, Shan HUANG, Li-ping XV, Juan ZHANG, Yi-na WANG, Xiao-fei LI, Yong-rui YANG. The Application Value of Dry Fluorescent Luminescence in The Diagnosis and Treatment of HBV Infection. Journal of Kunming Medical University, 2021, 42(8): 65-70.  doi: 10.12259/j.issn.2095-610X.S20210812
    [10] Fan CAO, Yang-wen LIU, Lei WEI, Nan XIE, Yi-jian YANG, Cheng QIAN, Chun-mang LI, Bi-mang FU, Jiang-pin XU, Rong-ji YAN, Wang ZENG. Correlation between Hepatitis B Virus and Microvascular Invasion in Hepatocellular Carcinoma. Journal of Kunming Medical University, 2021, 42(3): 127-134.  doi: 10.12259/j.issn.2095-610X.S20210331
    [11] Yang Shao Yan , Wu Lu , Zhang Su Xian . . Journal of Kunming Medical University, 2020, 41(08): 155-161.
    [12] Gong Chen Yu , Yang Kai Run , Jiang Hua , Wang Zi Qi , Li Lan Jiang , Hu Li Ping , Wu Jian . . Journal of Kunming Medical University, 2020, 41(08): 139-144.
    [13] Qi Xiao , Zhong Zhao Ming , Sun Chuan Zheng . . Journal of Kunming Medical University, 2020, 41(05): 140-144.
    [14] Pu Dong , Li Xiao Fei , Yu Ting Ting , Wang Hong Ying , Zhang Run Wu , Li Li Hua , Bai Jing , Ding Cai Mei , Li Dong Ling , Yang Yong Rui . . Journal of Kunming Medical University, 2020, 41(06): 149-155.
    [15] Pu Dong , Yu Ting Ting , Wang Hong Ying , Li Li Hua , Zhang Run Wu , Ding Cai Mei , Bai Jing , Li Dong Ling , Li Xiao Fei . . Journal of Kunming Medical University, 2019, 40(11): 131-135.
    [16] Yang Yong Rui , Li Xiao Fei , Liu Jun , Guo Ying Wu , Shen Ling . . Journal of Kunming Medical University, 2018, 39(11): 110-113.
    [17] Yang Yi Fu , Wang Hua , Ma Jun , Luo Hai Bo , Yang Yan Long , Wang Ying Hua , Jiang Long , Zhang Yue . . Journal of Kunming Medical University, 2017, 38(02): 66-69.
    [18] Li Yong Mei , Liu Lu Ping , Liu 垚, Ao Li Juan . 我国康复医师专业化教育发展现状及改革. Journal of Kunming Medical University, 2017, 38(04): 1-4.
    [19] Li Yong Gang . Vertical Transmission of Hepatitis B Virus in Human Early Embryos. Journal of Kunming Medical University,
    [20] Guo Xian Li . . Journal of Kunming Medical University,
    • Supplements(0)
    • Cited By

  • Cited by

    Periodical cited type(5)

    1. 曾洲榆，官燕飞，倪文鹏，柯家龙，张炽伦. 呼吸道腺病毒感染儿童血清PCT、SAA、25(OH)D的检测及临床意义. 检验医学与临床. 2022(03): 408-410 .
    2. 李心怡，袁勇，付燕，朱燕. 不同年龄段妊娠早期妇女维生素D含量水平分布. 昆明医科大学学报. 2022(04): 137-141 . 本站查看
    3. 袁勇，李心怡，付燕，朱燕. 昆明地区妊娠期妇女、婴幼儿维生素D水平分析及妊娠期空腹血糖水平与维生素D水平的关联性. 昆明医科大学学报. 2022(09): 125-129 . 本站查看
    4. 张国栋，云莎，白玉新内蒙古自治区人民医院血液科，朱华，梁妍琰，江琰. 反复呼吸道感染患儿免疫功能与维生素缺乏的相关性研究. 解放军预防医学杂志. 2020(06): 67-69 .
    5. 李艳红，张娴，李燕，赵梦茹，赵琳，李琳霞. 云南省4个少数民族贫困地区6～23月龄婴幼儿维生素D水平及影响因素. 中华疾病控制杂志. 2019(10): 1224-1229 .

    Other cited types(2)

  • 加载中
    Created with Highcharts 5.0.7Chart context menuAccess Class DistributionFULLTEXT: 35.1 %FULLTEXT: 35.1 %META: 64.7 %META: 64.7 %PDF: 0.2 %PDF: 0.2 %FULLTEXTMETAPDF
    Created with Highcharts 5.0.7Chart context menuAccess Area Distribution其他: 4.6 %其他: 4.6 %其他: 0.0 %其他: 0.0 %China: 4.5 %China: 4.5 %Perth Amboy: 0.0 %Perth Amboy: 0.0 %上海: 7.6 %上海: 7.6 %东莞: 0.0 %东莞: 0.0 %九江: 0.0 %九江: 0.0 %亳州: 0.0 %亳州: 0.0 %保定: 0.0 %保定: 0.0 %内华达: 0.0 %内华达: 0.0 %北京: 20.9 %北京: 20.9 %十堰: 0.0 %十堰: 0.0 %南京: 0.0 %南京: 0.0 %南通: 0.0 %南通: 0.0 %合肥: 0.0 %合肥: 0.0 %呼和浩特: 0.0 %呼和浩特: 0.0 %和田: 0.0 %和田: 0.0 %咸阳: 0.0 %咸阳: 0.0 %哈尔滨: 0.0 %哈尔滨: 0.0 %哥伦布: 0.0 %哥伦布: 0.0 %嘉兴: 0.0 %嘉兴: 0.0 %大理: 0.0 %大理: 0.0 %天津: 0.1 %天津: 0.1 %安那罕: 0.0 %安那罕: 0.0 %宣城: 0.0 %宣城: 0.0 %密蘇里城: 0.0 %密蘇里城: 0.0 %常州: 0.1 %常州: 0.1 %张家口: 0.3 %张家口: 0.3 %扬州: 0.1 %扬州: 0.1 %无锡: 0.0 %无锡: 0.0 %昆明: 0.6 %昆明: 0.6 %晋城: 0.0 %晋城: 0.0 %杭州: 0.1 %杭州: 0.1 %武威: 0.0 %武威: 0.0 %武汉: 0.0 %武汉: 0.0 %沈阳: 0.0 %沈阳: 0.0 %泰安: 0.0 %泰安: 0.0 %洛阳: 0.0 %洛阳: 0.0 %淮南: 0.0 %淮南: 0.0 %温州: 0.0 %温州: 0.0 %湖州: 0.0 %湖州: 0.0 %湛江: 0.0 %湛江: 0.0 %漯河: 0.1 %漯河: 0.1 %石家庄: 0.1 %石家庄: 0.1 %福州: 0.0 %福州: 0.0 %绍兴: 0.0 %绍兴: 0.0 %芒廷维尤: 1.8 %芒廷维尤: 1.8 %芝加哥: 0.2 %芝加哥: 0.2 %苏州: 0.0 %苏州: 0.0 %茂名: 0.0 %茂名: 0.0 %西宁: 0.8 %西宁: 0.8 %许昌: 0.0 %许昌: 0.0 %贵阳: 0.0 %贵阳: 0.0 %赤峰: 0.0 %赤峰: 0.0 %运城: 0.1 %运城: 0.1 %连云港: 0.0 %连云港: 0.0 %遵义: 0.0 %遵义: 0.0 %邯郸: 0.0 %邯郸: 0.0 %郑州: 0.0 %郑州: 0.0 %长沙: 0.1 %长沙: 0.1 %青岛: 0.0 %青岛: 0.0 %马赛: 0.0 %马赛: 0.0 %驻马店: 56.9 %驻马店: 56.9 %其他其他ChinaPerth Amboy上海东莞九江亳州保定内华达北京十堰南京南通合肥呼和浩特和田咸阳哈尔滨哥伦布嘉兴大理天津安那罕宣城密蘇里城常州张家口扬州无锡昆明晋城杭州武威武汉沈阳泰安洛阳淮南温州湖州湛江漯河石家庄福州绍兴芒廷维尤芝加哥苏州茂名西宁许昌贵阳赤峰运城连云港遵义邯郸郑州长沙青岛马赛驻马店

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索
    Get Citation
    PDF
    XML

    Article Metrics

    Article views (3105) PDF downloads(19) Cited by(7)
    Proportional views
    Related

    Copyright © 《昆明医科大学学报》编辑部  滇ICP备00000000号-0

    Publishing: 昆明医科大学学报编辑部

    Supported by: Beijing Renhe Information Technology Co. Ltd    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return