Effects of Subcutaneous Injection of Quick Acting Insulin Analogues at Different Time Points on Blood Glucose Level and MCP-1 Level in Patients with Hyperglycemic Crisis

Jie AN; Hui LIU; Shuohua CHEN

doi:10.12259/j.issn.2095-610X.S20220428

Volume 43 Issue 4

Apr. 2022

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Jie AN, Hui LIU, Shuohua CHEN. Effects of Subcutaneous Injection of Quick Acting Insulin Analogues at Different Time Points on Blood Glucose Level and MCP-1 Level in Patients with Hyperglycemic Crisis[J]. Journal of Kunming Medical University, 2022, 43(4): 142-145. doi: 10.12259/j.issn.2095-610X.S20220428

Citation:

Jie AN, Hui LIU, Shuohua CHEN. Effects of Subcutaneous Injection of Quick Acting Insulin Analogues at Different Time Points on Blood Glucose Level and MCP-1 Level in Patients with Hyperglycemic Crisis[J]. Journal of Kunming Medical University, 2022, 43(4): 142-145. doi: 10.12259/j.issn.2095-610X.S20220428

Citation:

Jie AN, Hui LIU, Shuohua CHEN. Effects of Subcutaneous Injection of Quick Acting Insulin Analogues at Different Time Points on Blood Glucose Level and MCP-1 Level in Patients with Hyperglycemic Crisis[J]. Journal of Kunming Medical University, 2022, 43(4): 142-145. doi: 10.12259/j.issn.2095-610X.S20220428

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Effects of Subcutaneous Injection of Quick Acting Insulin Analogues at Different Time Points on Blood Glucose Level and MCP-1 Level in Patients with Hyperglycemic Crisis

doi: 10.12259/j.issn.2095-610X.S20220428

Jie AN¹,
Hui LIU^{2
,
,},
Shuohua CHEN³

1.
Quality Control Office
2.
Dept. of Infectious Diseases
3.
Dept. of Cardiology，Kailuan General Hospital Affiliated to North China University of Science and Technology，Tangshan Hebei 063000，China

Received Date: 2022-02-17
Available Online: 2022-03-15
Publish Date: 2022-04-25

Abstract

Abstract

Objective To investigate the effects of subcutaneous injection of quick acting insulin analogues on blood glucose level and MCP-1 in patients with hyperglycemic crisis. Methods A total of 89 patients with hyperglycemia crisis in our hospital from March 2017 to November 2018 were randomly divided into observation group （n = 45, subcutaneous injection of insulin analogue after insulin injection with micropump stopped） and control group （n = 44, insulin analogues were administered subcutaneously 1 hour before the insulin micropump was discontinued）. The mean blood glucose values and blood glucose fluctuation amplitude of patients in the two groups were measured at 0.5 and 1 h before pump withdrawal and 0.5, 1 and 2 h after pump withdrawal. White blood cell index （WBC）, urine ketone body, monocyte chemochemic protein-1 （MCP-1）, insulin resistance index （HOMA-IR）, osmotic pressure and anionic gap were detected in 2 groups > 24 h, and the changes of patients status were analyzed. Results There was no significant difference in blood glucose fluctuation between 2 groups at 0.5 h before pump stop, 0.5, 1 and 2 h after pump stop （P > 0.05）. There were no differences in homA-IR, WBC, MCP-1, urine ketone body, osmotic pressure and anionic gap between 2 groups before and after insulin analogue injection at different time points for 24 h （P > 0.05）. Conclusion For patients with hyperglycemic crisis, the conversion of subcutaneous insulin injection can be carried out simultaneously when the intravenous pump injection of insulin is stopped, and there is no effect on the blood glucose fluctuation, HOMA-IR, MCP-1, urinary ketone body, WBC, osmotic pressure and anion gap indexes 24 hours before and after injection.
- Insulin analogues,
- Subcutaneous injection,
- Hyperglycemic crisis,
- Diabetes,
- MCP-1,
- HOMA-IR

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References(15)

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