Diagnostic Value of Gated Myocardial Perfusion Imaging Combined with NT-proBNP in Chronic Heart Failure

Feipeng WU; Xiandong ZHENG; Qiyan WU; Liju HONG; Lei YUE; Rui YANG; Dandan CHEN; Youjun ZHOU

doi:10.12259/j.issn.2095-610X.S20220511

Volume 43 Issue 5

May 2022

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Feipeng WU, Xiandong ZHENG, Qiyan WU, Liju HONG, Lei YUE, Rui YANG, Dandan CHEN, Youjun ZHOU. Diagnostic Value of Gated Myocardial Perfusion Imaging Combined with NT-proBNP in Chronic Heart Failure[J]. Journal of Kunming Medical University, 2022, 43(5): 133-139. doi: 10.12259/j.issn.2095-610X.S20220511

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Diagnostic Value of Gated Myocardial Perfusion Imaging Combined with NT-proBNP in Chronic Heart Failure

doi: 10.12259/j.issn.2095-610X.S20220511

Dept. of Nuclear Medicine，Yan’an Hospital Affiliated to Kunming Medical University， Kunming Yunnan 650051，China

Received Date: 2022-01-11
Publish Date: 2022-05-25

Abstract

Abstract

Objectives To investigate the clinical value of gated myocardial perfusion imaging （GMPI）, high-sensitivity C-reactive protein （Hs-CRP） and N-terminal B-type natriuretic peptide （NT-proBNP） in the differential diagnosis of chronic heart failure. Methods Eighty one patients ultimately diagnosed with chronic heart failure by GMPI examination at Yanan Hospital Affiliated to Kunming Medical University between January 2020 and December 2021 were included as the heart failure group, sixty five subjects with a final diagnosis of non heart failure by GMPI examination during the same period were selected as the non heart failure group. After that, GMPI indicators: PHB, PSD, LVEF, LVEDV, LVESV, PFR and laboratory indicators: Hs-CRP, NT-proBNP were collected for all enrolled subjects so as to analyze the diagnostic efficacy of each parameter of GMPI, Hs-CRP and NT-proBNP indicators for chronic heart failure. Results All parameters of GMPI and AUC of NTpro-BNP in the diagnosis of chronic heart failure were > 0.800, P < 0.001; the AUC of Hs-CRP in the diagnosis of heart failure was 0.640, P < 0.05; the AUC of the combined scheme of LVEDV + LVESV + NTpro-BNP was 0.937, P < 0.001. Comparing AUC of different parameters: there was no significant difference between GMPI and NTpro-BNP （ P > 0.05）, all parameters of GMPI and AUC of NTpro-BNP were higher than Hs-CRP （ P < 0.05）, the AUC of the combined scheme of LVEDV + LVESV + NTpro-BNP was higher than that of GMPI, NTpro-BNP and Hs-CRP （ P < 0.05）. Conclusion The value of Hs-CRP alone in the differential diagnosis of chronic heart failure is limited; GMPI parameters are equivalent to the accuracy of traditional heart failure index NTpro-BNP in the diagnosis of heart failure and have the high diagnostic efficacy in the differentiation of the heart failure; GMPI combined with NTpro-BNP can achieve the higher diagnostic accuracy, which is worthy of further clinical application.
- Chronic heart failure,
- Gated myocardial perfusion imaging,
- Hypersensitivity C-Reactive Protein,
- Diagnostic tests

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