Effect of Comprehensive Treatment for Aggressive Retinopathy of Prematurity

Siqi WU; Gang CHEN; Yishuang XIAO

doi:10.12259/j.issn.2095-610X.S20220513

Volume 43 Issue 5

May 2022

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Siqi WU, Gang CHEN, Yishuang XIAO. Effect of Comprehensive Treatment for Aggressive Retinopathy of Prematurity[J]. Journal of Kunming Medical University, 2022, 43(5): 127-132. doi: 10.12259/j.issn.2095-610X.S20220513

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Effect of Comprehensive Treatment for Aggressive Retinopathy of Prematurity

doi: 10.12259/j.issn.2095-610X.S20220513

1.
Dept. of Ophthalmology, Kunming Children’s Hospital, Kunming Yunnan 650034
2.
Dept. of Ophthalmology, Dali Maternal and Child Health Hospital, Dali Yunnan 671000, China

Received Date: 2022-01-11
Available Online: 2022-05-19
Publish Date: 2022-05-27

Abstract

Abstract

Objective To observe the effect of treatment for aggressive posterior retinopathy of prematurity （A-ROP）. Methods Retrospective case studies were made and 55 premature infants （110 eyes） who were diagnosed as A-ROP were selected from Kunming Children’s Hospital from July 2015 to May 2020, including 35 females and 20 males. The gestational age ranged from 24 to 37 （29.47±2.30） weeks and the birth weight ranged from 730 to 2250 （1322.09±322.75） g.All children received intravitreous injection of ranibizumb 10 mg/ml 0.03 ml （IVR） within 48 hours after the diagnosis. After IVR, the systemic and ocular adverse effects were observed during the follow-up and checked the retina after 1 week, 2 weeks, 1 month, 3 months, 6 months and 1 year for six times. Retinal Laser photocoagulation （LP） therapy was given to those recurrent eyes or not responding to ranibizumb. The time from IVR to LP were 26～48 （36.58±5.59） days. The effectiveness of IVP and the LP after IVR were divided into two groups to compare the gestational age, maternal age, length of NICU hospital stay, birth weight and the duration of oxygen inhalation, and compared the differences by t-test. Results 47.3% of eyes （52 eyes of 110 ） after IVR were effective, the lesions completely subsided, the additional lesions disappeared, and there was no neovascularization. The retinal vessels developed to zone 3. 57 eyes （51.8%） were treated with supplementary retinal LP. After IVR combined with LP, 1 eye （0.9%） had the recurrence, cataract combined with partial retinal detachment, vitrectomy and lensectomy were performed, and the retina was completely restored after the surgery. No ocular or systemic adverse reactions occurred in all pantients during the follow-up. Conclusion The comprehensive treatment of IVR and LP in A-ROP is effective.
- Aggressive posterior retinopathy of prematurity,
- Ranibizumb,
- Intravitreous injection,
- Laser photocoagulation

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