Effects of Different Frequency Intense Pulsed Light Treatment on Tear Film Stability and Meibomian Gland Function in Patients with Meibomian Gland Dysfunction

Liping LI; Hongchao ZHAO; Yanfang CHEN; Tao ZENG; Huiqiong ZHAO; Jun LI

doi:10.12259/j.issn.2095-610X.S20220708

Volume 43 Issue 7

Jul. 2022

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Article Navigation > Journal of Kunming Medical University > 2022 > 43(7): 62-67

Liping LI, Hongchao ZHAO, Yanfang CHEN, Tao ZENG, Huiqiong ZHAO, Jun LI. Effects of Different Frequency Intense Pulsed Light Treatment on Tear Film Stability and Meibomian Gland Function in Patients with Meibomian Gland Dysfunction[J]. Journal of Kunming Medical University, 2022, 43(7): 62-67. doi: 10.12259/j.issn.2095-610X.S20220708

Citation:

Liping LI, Hongchao ZHAO, Yanfang CHEN, Tao ZENG, Huiqiong ZHAO, Jun LI. Effects of Different Frequency Intense Pulsed Light Treatment on Tear Film Stability and Meibomian Gland Function in Patients with Meibomian Gland Dysfunction[J]. Journal of Kunming Medical University, 2022, 43(7): 62-67. doi: 10.12259/j.issn.2095-610X.S20220708

Citation:

Liping LI, Hongchao ZHAO, Yanfang CHEN, Tao ZENG, Huiqiong ZHAO, Jun LI. Effects of Different Frequency Intense Pulsed Light Treatment on Tear Film Stability and Meibomian Gland Function in Patients with Meibomian Gland Dysfunction[J]. Journal of Kunming Medical University, 2022, 43(7): 62-67. doi: 10.12259/j.issn.2095-610X.S20220708

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Effects of Different Frequency Intense Pulsed Light Treatment on Tear Film Stability and Meibomian Gland Function in Patients with Meibomian Gland Dysfunction

doi: 10.12259/j.issn.2095-610X.S20220708

1.
Dept. of Ophthalmology，Yuxi People’s Hospital，Yuxi Yunnan 653100
2.
Dept. of Ophthalmology，Affiliated Hospital of Yunnan University，Kunming Yunnan 650021，China

Received Date: 2022-04-27
Publish Date: 2022-07-25

Abstract

Abstract

Objective To analyze the effects of different frequency intense pulsed light （IPL）treatment on tear film stability and meibomian gland function in patients with MEibomian gland dysfunction （MGD）. Methods One hundred and forty eyes of 70 MGD patients admitted to Yuxi People’s Hospital from March 2021 to December 2021 were selected as the research objects. Patients were randomly divided into group A and group B according to the number table method, with 35 cases in each group. Group A received one IPL treatment at week 0, week 1, week 3 and week 7 （A total of 4 treatments）, and group B received one IPL treatment at week 0 and week 1 （A total of 2 treatments）.Fluorescein sodium ophthalmic dipstick was used to detect tear film rupture time. Mean non-invasive tear film rupture time （NIBUTav）, first non-invasive tear film rupture time （NIBUTf）, tear river height and corneal luciferin staining were measured by ocular surface analyzer. The tear film rupture time, OSDI scale score, NIBUTav, NIBUTf, lacrimal river height, meibomian gland secretion capacity score, meibomian gland secretion score and corneal fluorescein staining score were compared before and after IPL treatment at different frequencies. Results Compared with before treatment, the tear film rupture time and OSDI score in group A and GROUP B were significantly decreased, with statistical significance （P < 0.05）.The time of tear film rupture in group A was lower than that in group B, and the difference was statistically significant （ P < 0.05）, while the OSDI score between group A and GROUP B showed no significant difference （ P > 0.05）. After treatment, NIBUTav, NIBUTf and lacrimal river height were significantly increased in group A and group B, and NIBUTav and NIBUTf in group A were higher than those in group B, while the lacrimal river height was lower than those in group B, with statistical significance （ P < 0.05）.After treatment, meibomian gland secretion status score and secretory ability score of group A and GROUP B were decreased, and the score of group A was lower than that of group B, the difference was statistically significant （ P < 0.05）. After treatment, the corneal fluorescein staining score of group A and group B decreased, and the score of group A was higher than that of group B, the difference was statistically significant （ P < 0.05）. Conclusion IPL treatment at week 0, week 1, week 3 and week 7 for MGD patients can effectively improve the symptoms and signs of dry eye, and the efficacy and safety can be well balanced during the treatment.
- Meibomian gland dysfunction,
- Intense pulse light,
- Tear film stability,
- Meibomian gland function,
- Different frequencies

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