Volume 43 Issue 7
Jul.  2022
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Hong SHEN, Hairong HUA, Liping GAO, Yixiao HE, Xuezhi YANG, Xiangfei ZENG, Fang WANG, Jingling SONG. Expressions and Clinical Significance of LEA and CDw75 in Colorectal Adenocarcinoma[J]. Journal of Kunming Medical University, 2022, 43(7): 9-17. doi: 10.12259/j.issn.2095-610X.S20220717
Citation: Hong SHEN, Hairong HUA, Liping GAO, Yixiao HE, Xuezhi YANG, Xiangfei ZENG, Fang WANG, Jingling SONG. Expressions and Clinical Significance of LEA and CDw75 in Colorectal Adenocarcinoma[J]. Journal of Kunming Medical University, 2022, 43(7): 9-17. doi: 10.12259/j.issn.2095-610X.S20220717

Expressions and Clinical Significance of LEA and CDw75 in Colorectal Adenocarcinoma

doi: 10.12259/j.issn.2095-610X.S20220717
  • Received Date: 2022-04-08
    Available Online: 2022-06-24
  • Publish Date: 2022-07-14
  •   Objective  To investigate the expression and clinical significance of LEA and CDw75 in human colorectal adenocarcinoma.   Methods  The expressions of LEA and CDw75 were detected by immunohistochemistry staining in 11 cases of normal colorectal normal mucosa, 43 cases of colorectal adenomas, 51 cases of colorectal adenocarcinoma without lymph node metastasis, and 21 cases of colorectal adenocarcinoma with lymph node metastasis. Forty-five patients with colorectal adenocarcinoma were followed up, and the results of immunohistochemistry and follow-up were used for statistical analysis and prognosis analysis.   Results  1. The expression of LEA and CDw75 in normal colon mucosa, colorectal adenoma and colorectal adenocarcinoma was gradually increased (P < 0.05). It is related to the differentiation degree of colorectal adenocarcinoma (P < 0.05). It was not related with lymph node metastasis (P > 0.05). 2. The expression of LEA and CDw75 was higher in villous adenomas than in tubular adenomas (P < 0.05). 3. Cox regression survival analysis showed that patient gender, age, clinical stage, LEA and CDw75 expression were the prognostic factors of colorectal adenocarcinoma.   Conclusions  1. LEA and CDw75 may play a role during the development of colorectal adenocarcinoma. 2. Patient gender, age, clinical stage, LEA and CDw75 expression intensity can be used as prognostic indicators of colorectal adenocarcinoma.
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  • [1]
    Pourhoseingholi M A,Zali M R. Colorectal cancer screening:time for action in Iran[J]. World J Gastrointest Oncol,2012,4(4):82-83. doi: 10.4251/wjgo.v4.i4.82
    [2]
    Center M M,Jemal A,Smith R A,et al. Worldwide variations in colorectal cancer[J]. CA Cancer J Clin,2009,59(6):366-378. doi: 10.3322/caac.20038
    [3]
    Brenner D E,Rennert G. Fecal dna biomarkers for the detection of colorectal neoplasia:attractive,but is it feasible[J]. J Natl Cancer Inst,2005,97(15):1107-1109. doi: 10.1093/jnci/dji244
    [4]
    Bleday R,Song J,Walker E S,et al. Characterization of a new monoclonal antibody to a cell surface antigen on colorectal cancer and fetal gut tissues[J]. Cancer,1986,57(3):433-440. doi: 10.1002/1097-0142(19860201)57:3<433::AID-CNCR2820570305>3.0.CO;2-Q
    [5]
    王明武,宋今丹. 人侵袭性结肠癌细胞内质网的超微结构[J]. 中国医科大学学报,2000,29(6):401-403. doi: 10.3969/j.issn.0258-4646.2000.06.001
    [6]
    Dezheng Yuan,Hang Chen,Shuo Wang,et al. Identification of LEA,a podocalyxin-like glycoprotein,as a predictor for the progression of colorectal cancer[J]. Cancer Med,2018,7(10):5155-5166. doi: 10.1002/cam4.1765
    [7]
    WHO Classification of Tumours Editorial Board. World Health Organization classification of tumours [M]//Naglegaal I D, Arends M J, Odze R D, et al. Digestive System Tumours-Tumours of the Colon and Rectum. 5th Edition. Switzerland: World Health Organization, 2019: 157-192.
    [8]
    Bayascas J R. PDK1:the major transducer of PI 3-kinase actions[J]. Curr Top Microbiol Immunol,2010,346(1):9-29.
    [9]
    万德森,陈功. 结直肠癌的流行病学及其危险因素研究近况[J]. 实用癌症杂志,2000,15(2):220-222.
    [10]
    万德森. 结直肠癌流行趋势及对策[J]. 癌症,2009,28(9):897-902. doi: 10.3321/j.issn:1000-467X.2009.09.001
    [11]
    Rajaratnam S G,Dennett E R. Development of metachronous neoplasms after colorectal cancer resection:absence of synchronous neoplasms predicts a lower risk[J]. N Z Med J,2009,122(1294):61-66.
    [12]
    Shi C,Gao F,Gao X,et al. A novel anti-VEGF165 monoclonal antibody-conjugated liposomal nanocarrier system:Physical characterization and cellular uptake evaluation in vitro and in vivo[J]. Biomed Pharmacother,2015,69(1):191-200.
    [13]
    万文徽. 血清肿瘤标志的临床应用[J]. 实用癌症杂志,1998,13(4):316-317. doi: 10.3969/j.issn.1001-5930.1998.04.039
    [14]
    王之章,姜卫国,宋今丹,等. 抗结肠癌单克隆抗体ND-1在结肠癌组织的标记[J]. 中国医科大学学报,1991,20(2):98-101.
    [15]
    刘小平,刘恩卿,姜卫国,等. 肿瘤相关抗原LEA在大肠腺瘤组织中的表达[J]. 中国医科大学学报,1995,24(1):38-40.
    [16]
    White K N,Hope D B. Characterization of aspirin hydrolase of guinea-pig liver cytoplasm[J]. Biochim Biophys Acta,1984,785(3):132-137. doi: 10.1016/0167-4838(84)90137-7
    [17]
    Hakomori S. Aberrant glycosylation in tumors and tumor-associated carbohydrate antigens[J]. Adv Cancer Res,1989,52(1):257-331.
    [18]
    李连弟,鲁凤珠,张思维,等. 中国恶性肿瘤死亡率20年变化趋势和近期预测分析[J]. 中华肿瘤杂志,1997,19(1):3-9. doi: 10.3760/j.issn:0253-3766.1997.01.001
    [19]
    Gruszewska E,Chrostek L. The alterations of glycosylation in malignant diseases[J]. Pol Merkur Lekarski,2013,34(199):58-61.
    [20]
    Óscar Mariño-Crespo,Almudena Fernández-Briera,Emilio Gil-Martín. Identification of proteins with the CDw75 epitope in human colorectal cancer[J]. Oncol Lett,2018,15(1):580-587.
    [21]
    Shiozaki K,Yamaguchi K,Takahashi K,et al. Regulation of sialyl lewis antigen expression in colon cancer cells by sialidase neu4[J]. J Biol Chem,2011,286(24):21052-21061. doi: 10.1074/jbc.M111.231191
    [22]
    Yang S H,Jiang J K,Chang S C,et al. Clinical significance of ca19-9 in the follow-up of colorectal cancer patients with elevated preoperative serum ca19-9[J]. Hepatogastroenterology,2013,60(125):1021-1027.
    [23]
    蒋小猛,于亚杰,吴莺,等. hTERT和CDw75在胃癌癌组织中的表达及意义[J]. 山东医药,2009,1(1):86-87. doi: 10.3969/j.issn.1002-266X.2009.01.056
    [24]
    夏磊,王元书,崔淑香. 唾液酸转移酶与肿瘤进展和转移[J]. 国际肿瘤学杂志,2009,36(2):86-88. doi: 10.3760/cma.j.issn.1673-422X.2009.02.002
    [25]
    Li M,Vemulapalli R,Ullah A,et al. Downregulation of a human colonic sialyltransferase by a secondary bile acid and a phorbol ester[J]. Am J Physiol,1998,274(1):599-606.
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