Correlation between Internal Carotid Artery Stenosis and Cognitive Impairment

Yao HUANG; Xi LI; Bo YAN; Lei LEI; Zegang YIN; Jin FAN; Peng BAI

doi:10.12259/j.issn.2095-610X.S20230105

Volume 44 Issue 1

Jan. 2023

Turn off MathJax

Article Contents

Article Navigation > Journal of Kunming Medical University > 2023 > 44(1): 70-75

Yao HUANG, Xi LI, Bo YAN, Lei LEI, Zegang YIN, Jin FAN, Peng BAI. Correlation between Internal Carotid Artery Stenosis and Cognitive Impairment[J]. Journal of Kunming Medical University, 2023, 44(1): 70-75. doi: 10.12259/j.issn.2095-610X.S20230105

Citation:

Yao HUANG, Xi LI, Bo YAN, Lei LEI, Zegang YIN, Jin FAN, Peng BAI. Correlation between Internal Carotid Artery Stenosis and Cognitive Impairment[J]. Journal of Kunming Medical University, 2023, 44(1): 70-75. doi: 10.12259/j.issn.2095-610X.S20230105

Citation:

PDF( 828 KB)

Correlation between Internal Carotid Artery Stenosis and Cognitive Impairment

doi: 10.12259/j.issn.2095-610X.S20230105

Yao HUANG¹,
Xi LI¹,
Bo YAN²,
Lei LEI¹,
Zegang YIN¹,
Jin FAN^{1
,
,},
Peng BAI^{3
,
,}

1.
Dept. of Neurology，The General Hospital of the Western Theater Command，Chengdu Sichuan 610000
2.
Dept. of Cerebrovascular Disease，Guangyuan Central Hospital，Guangyuan Sichuan 628000
3.
Dept. of NeurosurgeryⅡ，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032，China

Received Date: 2022-09-25
Available Online: 2022-12-24
Publish Date: 2023-01-18

Abstract

Abstract

Objective To investigate the correlation of different degrees and sides of internal carotid artery stenosis with cognitive impairment. Methods From June 2017 to August 2018, patients for cerebrovascular examination with CTA or DSA were selected from the neurology department of a certain hospital. They were divided into the stenosis group and the control group according to the examination results. All the enrolled patients were examined with memory assessment scale+modified WCST. The assessment scores were recorded and the difference of scores among the patients in each group was statistically analyzed. Results 65 cases were included in the study, which were divided into stenosis group （34 cases in total） and control group （31 cases in total） according to the examination results.The stenosis group was divided into mild stenosis group （15 cases in total） and moderate severe stenosis group （19 cases in total） according to the degree of stenosis. And the stenosis group was again divided into left stenosis group （24 cases in total） and right stenosis group （ 10 cases in total） according to the side. The memory and executive ability of the stenosis group and the control group were significantly impaired, the difference was statistically significant （P < 0.05）. The degree and side of stenosis had no correlation with memory and executive ability, and the difference was not statistically significant （P > 0.05）. Conclusion Internal carotid artery stenosis significantly affects cognitive function as indicated by memory and executive ability. However, the severity and side of stenosis are not related to cognitive function.
- Internal carotid artery,
- Carotid stenosis,
- Cognitive impairment,
- Vascular cognitive impairment

FullText(HTML)

References(22)

References

[1]	Wong K S,Huang Y N,Yang H B,et al. A door-to-door survey of intracranial atherosclerosis in Liangbei County, China[J]. Neurology,2007,68(23):2031-2044. doi: 10.1212/01.wnl.0000264426.63544.ee
[2]	王小刚,杨连军,杨茂生,等. 大脑中动脉狭窄的高分辨力MRI管壁成像特点研究[J]. 医疗卫生装备,2018,39(6):68-71.
[3]	Petersen R C,Smith G E,Waring S C,et al. Aging, memory, and mild cognitive impairment[J]. Int Psychogeriatr,1997,9(1):65-69. doi: 10.1017/S1041610297004213
[4]	Teeters D A,Moua T,Li G,et al. Mild cognitive impairment and risk of critical illness[J]. Crit Care Med,2016,44(11):2045-2051. doi: 10.1097/CCM.0000000000001842
[5]	O’brien J T,Erkinjuntti T,Reisberg B,et al. Vascular cognitive impairment[J]. Lancet Neurol,2003,2(2):89-98. doi: 10.1016/S1474-4422(03)00305-3
[6]	Kim J J,Schwartz S,Wen J,et al. Comparison of neurocognitive outcomes after carotid endarterectomy and carotid artery stenting[J]. Am Surg,2015,81(10):1010-1014. doi: 10.1177/000313481508101020
[7]	Zhang H P,Ma X D,Chen L F,et al. Cognitive function after carotid endarterectomy: Early decline and later recovery[J]. Turk Neurosurg,2016,26(6):833-839.
[8]	Ishikawa M,Kusaka G,Terao S,et al. Improvement of neurovascular function and cognitive impairment after STA-MCA anastomosis[J]. J Neurol Sci,2017,15(373):201-207.
[9]	王宇生,邱大志,阴鲁鑫,等. 颈动脉内膜切除术对颈动脉狭窄患者认知功能的影响[J]. 局解手术学杂志,2019,28(2):112-117.
[10]	张继杰,牛小莉,王贺波,等. 支架植入术对认知功能障碍伴大脑中动脉狭窄患者认知功能的影响[J]. 中国介入影像与治疗学,2019,16(2):71-76. doi: 10.13929/j.1672-8475.201808004
[11]	中华医学会神经外科分会,中国医师协会神经外科分会,中国医师协会神经内科分会. 介入神经放射诊断治疗规范Ⅲ(修订稿)[J]. 中国脑血管病杂志,2005,2(10):476-480.
[12]	Ni J,Yao M,Gao S,et al. Stroke risk and prognostic factors of asymptomatic middle cerebral artery atherosclerotic stenosis[J]. J Neurol Sci,2011,301(1-2):63-65. doi: 10.1016/j.jns.2010.10.029
[13]	Xiang J. Carotid atherosclerosis promotes the progression of Alzheimer's disease: A three-year prospective study[J]. Exp Ther Med,2017,14(2):1321-1326. doi: 10.3892/etm.2017.4661
[14]	Nouri A,Martin A R,Mikulis D,et al. Magnetic resonance imaging assessment of degenerative cervical myelopathy:A review of structural changes and measurement techniques[J]. Neurosurg Focus,2016,40(6):E5. doi: 10.3171/2016.3.FOCUS1667
[15]	Skrobot O A,Attems J,Esiri M,et al. Vascular cognitive impairment neuropathology guidelines (VCING):He contribution of cerebrovascular pathology to cognitive impairment[J]. Brain,2016,139(11):2957-2969. doi: 10.1093/brain/aww214
[16]	Arvanitakis Z,Capuano A W,Leurgans S E,et al. The relationship of cerebral vessel pathology to brain microinfarcts[J]. Brain Pathol,2017,27(1):77-85. doi: 10.1111/bpa.12365
[17]	Dudvarski Stankovic N,Teodorczyk M,Ploen R,et al. Microglia-blood vessel interactions: A double-edged sword in brain pathologies[J]. Acta Neuropathol,2016,131(3):347-363. doi: 10.1007/s00401-015-1524-y
[18]	张少杰. 无症状性单侧大脑中动脉狭窄或闭塞患者认知功能改变的研究[D]. 长春: 吉林大学硕士学位论文, 2016.
[19]	周海生,陈伟建,郑汉朋,等. 单侧颈动脉狭窄致继发性慢性脑缺血的CT灌注研究[J]. 临床放射学杂志,2015,34(9):1395-1398. doi: 10.13437/j.cnki.jcr.2015.09.010
[20]	Jin W N,Shi S X,Li Z,et al. Depletion of microglia exacerbates postischemic inflammation and brain injury[J]. J Cereb Blood Flow Metab,2017,37(6):2224-2236. doi: 10.1177/0271678X17694185
[21]	Chen A,Akinyemi R O,Hase Y,et al. Frontal white matter hyperintensities, clasmatodendrosis and gliovascular abnormalities in ageing and post-stroke dementia[J]. Brain,2016,139(Pt 1):242-258.
[22]	贾建平. 重视血管性认知障碍的早期诊断和干预[J]. 中华神经科杂志,2005,38(1):7-9. doi: 10.3760/j.issn:1006-7876.2005.01.004

Relative Articles(20)

Relative Articles

[1]	Yuanjia TAO, Yuqi CHENG, Hezhi YAN, Xiangyu SU, Xianyu CHEN, Hongyan JIANG. Study on Influencing Factors of Cognitive Impairment in Late-life Depression Patients. Journal of Kunming Medical University, 2024, 45(6): 94-99. doi: 10.12259/j.issn.2095-610X.S20240612
[2]	Yi HUANG, Yongjian HUANG, Ling MAI, Ting LUO. Relationship between TGF-β/Smads Signaling Pathway and Cognitive Dysfunction in Patients with Aneurysmal Subarachnoid Hemorrhage. Journal of Kunming Medical University, 2024, 45(3): 127-132. doi: 10.12259/j.issn.2095-610X.S20240319
[3]	Qinghua YI, Juan XU, Ailian LI, Linyun TIAN, Dongli SANG, Jing XIONG, Chang DENG. Association between Body Mass Index and Cognitive Impairment in the Elderly in Guandu District of Kunming City. Journal of Kunming Medical University, 2024, 45(10): 122-129. doi: 10.12259/j.issn.2095-610X.S20241019
[4]	Yanmei JI, Wenjun LI, Qingyun LI, Ni GUO, Ni MENG, Dan ZHOU, Qiuyu LI, Xingfang JIN. The Analysis of Related Factors of Cognitive Impairment after the Acute Ischemic Stroke and Construction of Nomogram Model. Journal of Kunming Medical University, 2024, 45(5): 73-81. doi: 10.12259/j.issn.2095-610X.S20240511
[5]	Xiaopei LV, Shuai YUAN. The Effect of Butylphthalide on Cognitive Dysfunction after the Stroke Caused by Cerebral Small Vessel Disease and Its Effect on Cerebral Blood Perfusion. Journal of Kunming Medical University, 2023, 44(9): 143-147. doi: 10.12259/j.issn.2095-610X.S20230922
[6]	Rong Dong Jing , Zhang Yu An , Zhang Yu Lin , Xiao Yi , Chang Yan Ping . . Journal of Kunming Medical University, 2020, 41(04): 121-126.
[7]	Cen Jian Chang , Gao Hong , Liu Bo Hu , Wu Jun , Qian Xiao Min , Wang Jing , Su Ping . . Journal of Kunming Medical University, 2020, 41(06): 109-114.
[8]	Wang Ru Jiao , Zhang Ling , Yang Ji Ying , Zhou Qiang , Sun Feng Qin , Zhang Yu Lin , Huang Wei . . Journal of Kunming Medical University, 2020, 41(01): 68-72.
[9]	Ge A, Xiao-yan LIU, Li LIU, Yu-jia ZHAN, Ting-ting TANG, Jingnan TAO. Family Burden in Elderly Hip Fracture Patients with Cognitive Impairment and Its Influencing Factors. Journal of Kunming Medical University, 2020, 41(12): 168-172. doi: 10.12259/j.issn.2095-610X.S20201246
[10]	Zhang Jin Zhi , Zhang Xiao , Liu Zhen Zhen . . Journal of Kunming Medical University, 2019, 40(02): 106-109.
[11]	Huang Yao , Bai Peng . . Journal of Kunming Medical University, 2019, 40(05): 80-85.
[12]	Han Juan , Xu Hong . . Journal of Kunming Medical University, 2018, 39(10): 68-71.
[13]	Mei Rong , Chen Wen Li , Zhang Feng Li , Meng Qiang , Zhao Zhong , Ding Li . . Journal of Kunming Medical University, 2017, 38(03): 64-70.
[14]	Li Ming . Curative Effect of Computer Assisted Cognitive Rehabilitation System for Cognitive Impairment after Stroke. Journal of Kunming Medical University,
[15]	Huang Wei . . Journal of Kunming Medical University,
[16]	Cai Ya Mei . . Journal of Kunming Medical University,
[17]	He Bin . . Journal of Kunming Medical University,
[18]	Liu Shu Qing . . Journal of Kunming Medical University,
[19]	Zhao Xiao Hong . . Journal of Kunming Medical University,
[20]	Chen Peng . . Journal of Kunming Medical University,