Effect of Different Intestinal Surgical Methods on Prognosis of Patients with Intestinal Invasive Epithelial Ovarian Cancer

Yaping JIANG; Hongying YANG; Haohan WANG; Xianling Ning; Xielan YANG

doi:10.12259/j.issn.2095-610X.S20230109

Volume 44 Issue 1

Jan. 2023

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Article Navigation > Journal of Kunming Medical University > 2023 > 44(1): 85-90

Yaping JIANG, Hongying YANG, Haohan WANG, Xianling Ning, Xielan YANG. Effect of Different Intestinal Surgical Methods on Prognosis of Patients with Intestinal Invasive Epithelial Ovarian Cancer[J]. Journal of Kunming Medical University, 2023, 44(1): 85-90. doi: 10.12259/j.issn.2095-610X.S20230109

Citation:

Yaping JIANG, Hongying YANG, Haohan WANG, Xianling Ning, Xielan YANG. Effect of Different Intestinal Surgical Methods on Prognosis of Patients with Intestinal Invasive Epithelial Ovarian Cancer[J]. Journal of Kunming Medical University, 2023, 44(1): 85-90. doi: 10.12259/j.issn.2095-610X.S20230109

Citation:

Yaping JIANG, Hongying YANG, Haohan WANG, Xianling Ning, Xielan YANG. Effect of Different Intestinal Surgical Methods on Prognosis of Patients with Intestinal Invasive Epithelial Ovarian Cancer[J]. Journal of Kunming Medical University, 2023, 44(1): 85-90. doi: 10.12259/j.issn.2095-610X.S20230109

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Effect of Different Intestinal Surgical Methods on Prognosis of Patients with Intestinal Invasive Epithelial Ovarian Cancer

doi: 10.12259/j.issn.2095-610X.S20230109

Dept. of Gynecology，The 3rd Affiliated Hospital of Kunming Medical University/Yunnan Cancer Hospital，Kunming Yunnan 650118，China

Received Date: 2022-10-10
Available Online: 2022-12-23
Publish Date: 2023-01-18

Abstract

Abstract

Objective To investigate the effect of intestinal segment resection and local tumor removal on the prognosis of patients with intestinal metastatic epithelial ovarian cancer. Methods The clinical data of the patients who were admitted to Yunnan Province Tumor Hospital with advanced epithelial ovarian cancers from June 2017 to June 2021 were reviewed. All of the patients were treated by the same woman tumor expert of the Department of Gynecology and his team and the safety and feasibility of two kinds of operation methods were compared. Results Among 56 patients, 33 （58.9%） underwent the intestinal resection and anastomosis, and 23 （41.1%） underwent the intestinal tumor removal and bowel repair. There was no significant difference in satisfactory tumor reduction rate between the two groups （63.6%, 87.0%, P > 0.05）. In the median follow-up time of 24.5 months （18.75～42.75）, the recurrence rates in the enterectomy group and the tumor excision group were 57.6% and 42.4% respectively, the mortality rates were 78.8% and 82.6%, respectively, and the median relapse-free survival time were 31 months and 19 months, respectively, with no statistical significance （P > 0.05）. Operations in intestinal resection group were carried out with longer time, more difficulties, more blood loss and more blood transfusion. The incidence of postoperative complications was higher, and the difference was statistically significant （P < 0.05）. Conclusion There is no significant difference in the tumor reduction outcome and survival of patients with ovarian cancer tumor cell reduction after the intestinal resection and tumor removal, but the patients may face more complications and poorer quality of life after the intestinal resection. Therefore, during the operation, the depth of tumor invasion of the intestinal wall, the scope of intestinal invasion and the separability of the tumor should be fully assessed, so as to preserve the intestinal tract as much as possible, and to reduce the occurrence of postoperative complications.
- Epithelial ovarian cancer,
- Debulking surgery,
- Intestinal surgery,
- Prognosis

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References(18)

References

[1]	Sung H,Ferlay J,Siegel R L,et al. Global Cancer Statistics 2020: Globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin,2021,71(3):209-249. doi: 10.3322/caac.21660
[2]	Chang S J,Hodeib M,Chang J,et al. Survival impact of complete cytoreduction to no gross residual disease for advanced-stage ovarian cancer: A meta-analysis[J]. Gynecol Oncol,2013,130(3):493-498. doi: 10.1016/j.ygyno.2013.05.040
[3]	Obermair A,Hagenauer S,Tamandl D,et al. Safety and efficacy of low anterior en bloc resection as part of cytoreductive surgery for patients with ovarian cancer[J]. Gynecol Oncol,2001,83(1):115-120. doi: 10.1006/gyno.2001.6353
[4]	Bryant C L,Lunniss P J,Knowles C H,et al. Anterior resection syndrome[J]. The Lancet Oncology,2012,13(9):403-408. doi: 10.1016/S1470-2045(12)70236-X
[5]	Kranawetter M, Ataseven B,Grimm C,et al. Low anterior resection syndrome (LARS) in patients with epithelial ovarian cancer after primary debulking surgery[J]. Gynecol Oncol,2019,154(3):577-582. doi: 10.1016/j.ygyno.2019.06.015
[6]	Bidzinski M,Derlatka P,Kubik P,et al. The evaluation of intra-and postoperative complications related to debulking surgery with bowel resection in patients with FIGO stage III-IV ovarian cancer[J]. Int J Gynecol Cancer,2007,17(5):993-997. doi: 10.1111/j.1525-1438.2007.00896.x
[7]	Aletti G D,Podratz K C,Jones M B,et al. Role of rectosigmoidectomy and stripping of pelvic peritoneum in outcomes of patients with advanced ovarian cancer[J]. J Am Coll Surg,2006,203(4):521-526. doi: 10.1016/j.jamcollsurg.2006.06.027
[8]	Hertel H,Diebolder H,Herrmann J,et al. Is the decision for colorectal resection justified by histopathologic findings: A prospective study of 100 patients with advanced ovarian cancer[J]. Gynecol Oncol,2001,83(3):481-484. doi: 10.1006/gyno.2001.6338
[9]	Kim M,Suh D H,Park J Y,et al. Survival impact of low anterior resection in patients with epithelial ovarian cancer grossly confined to the pelvic cavity:A Korean multicenter study[J]. J Gynecol Oncol,2018,29(4):60-61. doi: 10.3802/jgo.2018.29.e60
[10]	Vergote I,Gonzalez-Martin A,Lorusso D,et al. Clinical research in ovarian cancer: Consensus recommendations from the Gynecologic Cancer InterGroup[J]. Lancet Oncol,2002,23(8):374-384.
[11]	Di Donato V,Di Pinto A,Giannini A,et al. Modified fragility index and surgical complexity score are able to predict postoperative morbidity and mortality after cytoreductive surgery for advanced ovarian cancer[J]. Gynecol Oncol,2021,161(1):4-10. doi: 10.1016/j.ygyno.2020.08.022
[12]	Dindo D,Demartines N,Clavien P A,et al. Classification of surgical complications: A new proposal with evaluation in a cohort of 6336 patients and results of a survey[J]. Ann Surg,2004,240(2):205-213. doi: 10.1097/01.sla.0000133083.54934.ae
[13]	Rustin G J,Vergote I,Eisenhauer E,et al. Definitions for response and progression in ovarian cancer clinical trials incorporating RECIST 1.1 and CA 125 agreed by the Gynecological Cancer Intergroup (GCIG)[J]. Int J Gynecol Cancer,2011,21(2):419-423. doi: 10.1097/IGC.0b013e3182070f17
[14]	Vito Andrea C,Uccella S, Sozzi G,et al. Primary site disease and recurrence location in ovarian cancer patients undergoing primary debulking surgery vs. interval debulking surgery[J]. Eur J Surg Oncol,2021,47(5):1075-1082. doi: 10.1016/j.ejso.2020.09.014
[15]	Gallotta V,Fanfani F,Vizzielli G,et al. Douglas peritonectomy compared to recto-sigmoid resection in optimally cytoreduced advanced ovarian cancer patients: Analysis of morbidity and oncological outcome[J]. Eur J Surg Oncol,2011,37(12):1085-1092. doi: 10.1016/j.ejso.2011.09.003
[16]	Plotti F,Montera R,Aloisi A,et al. Total rectosigmoidectomy versus partial rectal resection in primary debulking surgery for advanced ovarian cancer[J]. Eur J Surg Oncol,2016,42(3):383-390. doi: 10.1016/j.ejso.2015.12.001
[17]	Park J Y,Seo S S,Kang S,et al. The benefits of low anterior en bloc resection as part of cytoreductive surgery for advanced primary and recurrent epithelial ovarian cancer patients outweigh morbidity concerns[J]. Gynecol Oncol,2006,103(3):977-984. doi: 10.1016/j.ygyno.2006.06.004
[18]	Park S J,Mun J,Lee E J,et al. Clinical phenotypes of tumors invading the rectosigmoid colon affecting the extent of debulking surgery and survival in advanced ovarian cancer[J]. Front Oncol,2021,22(11):631-673.

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