Diagnostic Value of Interleukin-6，Interleukin-10，High-sensitivity C-reactive Protein and Procalcitonin in Children with Acute Lymphoblastic Leukemia Complicated by Infection

Shulan SHI; Lijuan QIU; Liyue KUI; Min SU; Bailing ZHOU; Rongjie LI; Jianming SUN

doi:10.12259/j.issn.2095-610X.S20230115

Volume 44 Issue 1

Jan. 2023

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Article Navigation > Journal of Kunming Medical University > 2023 > 44(1): 104-108

Shulan SHI, Lijuan QIU, Liyue KUI, Min SU, Bailing ZHOU, Rongjie LI, Jianming SUN. Diagnostic Value of Interleukin-6，Interleukin-10，High-sensitivity C-reactive Protein and Procalcitonin in Children with Acute Lymphoblastic Leukemia Complicated by Infection[J]. Journal of Kunming Medical University, 2023, 44(1): 104-108. doi: 10.12259/j.issn.2095-610X.S20230115

Citation:

Shulan SHI, Lijuan QIU, Liyue KUI, Min SU, Bailing ZHOU, Rongjie LI, Jianming SUN. Diagnostic Value of Interleukin-6，Interleukin-10，High-sensitivity C-reactive Protein and Procalcitonin in Children with Acute Lymphoblastic Leukemia Complicated by Infection[J]. Journal of Kunming Medical University, 2023, 44(1): 104-108. doi: 10.12259/j.issn.2095-610X.S20230115

Citation:

Shulan SHI, Lijuan QIU, Liyue KUI, Min SU, Bailing ZHOU, Rongjie LI, Jianming SUN. Diagnostic Value of Interleukin-6，Interleukin-10，High-sensitivity C-reactive Protein and Procalcitonin in Children with Acute Lymphoblastic Leukemia Complicated by Infection[J]. Journal of Kunming Medical University, 2023, 44(1): 104-108. doi: 10.12259/j.issn.2095-610X.S20230115

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Diagnostic Value of Interleukin-6，Interleukin-10，High-sensitivity C-reactive Protein and Procalcitonin in Children with Acute Lymphoblastic Leukemia Complicated by Infection

doi: 10.12259/j.issn.2095-610X.S20230115

1.
Clinical Laboratory.of Yunnan Children’s Medical Center/Kunming Children’s Hospital，Kunming Yunnan 650228
2.
Pharmacy Department.of Yunnan Clinical Research Center for Children’s Health and Disease，Kunming Yunnan 650228，China

Received Date: 2022-11-18
Available Online: 2022-12-24
Publish Date: 2023-01-18

Abstract

Abstract

Objective To explore peripheral blood interleukin-6 （ IL-6）, interleukin-10 （ IL-10） hypersensitive C-reactive protein （ hs-CRP） and procalcitonin （ PCT） in children with acute lymphoblastic leukemia （ ALL） co-infection. Methods A total of 141 children with ALL who were admitted to Kunming Children’s Hospital from January 2018 to December 2019 were selected as the research objects. 49 cases were entered into the uninfected group and 92 cases into the infection group （in which 69 cases with the mild infection and 23 cases with the severe infection） according to whether they were co-infected or not. The peripheral blood IL-6, IL-10, hs-CRP and PCT of the two groups were compared, and the diagnostic efficacy of the four infection indicators in ALL children with co-infection was analyzed. Results The four infection indexes in the peripheral blood of the infected group were higher than those in the non-infected group （P < 0.05）. Compared with the mild infection group, the four infection indexes in the severe infection group increased significantly. The area under the ROC curve （AUC） of IL-6, PCT, IL-10, hs-CRP and their combination in the diagnosis of ALL co-infection in peripheral blood were 0.887, 0.781, 0.765, 0.681 and 0.923, respectively. Conclusion IL-6, IL-10, hs-CRP and PCT have the certain diagnostic significance in the diagnosis of ALL co-infection. Among them, IL-6 has the highest diagnostic efficiency. The combination of the four can improve the diagnostic value of ALL co-infection.
- Interleukin-6,
- Interleukin-10,
- High-sensitivity C-reactive protein,
- Procalcitonin,
- Acute lymphoblastic leukemia,
- Infection

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References(16)

References

[1]	高陆,彭志元,任明强,等. 97例恶性血液病合并侵袭性真菌病临床分析[J]. 现代临床医学,2021,47(1):31-33. doi: 10.11851/j.issn.1673-1557.2021.01.012
[2]	黄莉,姚红霞,林丽娥,等. 急性白血病患者医院感染病原菌分布及影响因素分析[J]. 中华医院感染学杂志,2019,29(17):2631-2634.
[3]	郭雷,李艳,卢立慧,等. 53例急性白血病患儿死亡原因及危险因素分析[J]. 实用临床医药杂志,2021,25(8):43-45.
[4]	Lyons J L,Thakur K T,Lee R,et al. Utility of measuring (1,3)-β-d-glucan in cerebrospinal fluid for diagnosis of fungal central nervous system infection[J]. Clin Microbiol,2015,53(1):319-322. doi: 10.1128/JCM.02301-14
[5]	萧建华,张海平. Th1/Th2细胞因子谱与PCT在急性白血病患儿感染中的诊断价值[J]. 中华医院感染学杂志,2020,30(10):1564-1568.
[6]	王结珍,梁培松,王伟佳,等. 血清PCT,IL-6和CRP水平检测对白血病患者化疗并发败血症的诊断价值[J]. 现代检验医学杂志,2019,34(2):88-90. doi: 10.3969/j.issn.1671-7414.2019.02.023
[7]	吴敏媛,李志刚. “儿童急性淋巴细胞白血病诊疗建议(第四次修订)”解读[J]. 中华儿科杂志,2014,52(9):645-648. doi: 10.3760/cma.j.issn.0578-1310.2014.09.002
[8]	中华人民共和国卫生部. 医院感染诊断标准(试行)[J]. 中华医学杂志,2001,81(5):314-320. doi: 10.3760/j:issn:0376-2491.2001.05.027
[9]	Hatzistilianou M,Rekliti A,Athanassiadou F,et al. Procalci toninasanearly as an early marker of bacteria infection in neutropenic febrile children with acute lymphoblastic leukemia[J]. Flamm Res,2010,59(5):339-347.
[10]	Bal Z S,Sen S,Karapinar D Y,et al. The first reported catheterrelated brevibacterium casei bloodstream infestion in a child with acute leukemia and reviewew of the literature[J]. Braz J Infect Dis,2015,19(2):213-215.
[11]	宁方颖,蓝建平,陈一瑞,等. 高危急性淋巴细胞白血病患者维持治疗阶段营养状况与医院感染发生率的相关性研究[J]. 中华全科医学,2017,15(9):1582-1585. doi: 10.16766/j.cnki.issn.1674-4152.2017.09.039
[12]	刘颖,陈艳,万叶明,等. CRP与PCT和IL-6早期诊断儿童急性白血病化疗期间骨髓抑制合并感染的临床价值[J]. 中华医院感染学杂志,2020,30(18):2855-2858.
[13]	邓罗华,方代华,刘洋. Th1/Th2细胞因子谱在脓毒血症儿童中的表达研究[J]. 临床检验杂志(电子版),2020,9(2):38.
[14]	Rodriguez A,Reyes L F,Monclou J,et al. Relationship between acute kidney injury and serum procalcitonin (PCT) concentration in critically ill patients with influenza infection[J]. Med Intensiva,2018,42(7):399-408. doi: 10.1016/j.medin.2017.12.004
[15]	Li Z,Li M,Li F,et al. Paper-based chemiluminescence enzyme-linked immunosorbent assay enhanced by biotin-streptavidin system for high-sensitivity C-reactive protein detection[J]. Anal Biochem,2018,15(559):86-90.
[16]	Ding G Z,Li W S. The expressions and significance of APN,D-D,IL-17 and hs-CRP in patients with acute exacerbation of chronic obstructive pulmonary disease[J]. Eur Rev Med Pharmacol Sci,2018,22(19):6463-6468.

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