The Analysis of Influence Factors on Platelet Antibody Production and Clinical Transfusion Effects

Huaxiang CHAI; Ziyu LUO; Aizhi DUAN; Deying LI; Weiqun DONG

doi:10.12259/j.issn.2095-610X.S20230901

Volume 44 Issue 9

Sep. 2023

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Huaxiang CHAI, Ziyu LUO, Aizhi DUAN, Deying LI, Weiqun DONG. The Analysis of Influence Factors on Platelet Antibody Production and Clinical Transfusion Effects[J]. Journal of Kunming Medical University, 2023, 44(9): 62-68. doi: 10.12259/j.issn.2095-610X.S20230901

Citation:

Huaxiang CHAI, Ziyu LUO, Aizhi DUAN, Deying LI, Weiqun DONG. The Analysis of Influence Factors on Platelet Antibody Production and Clinical Transfusion Effects[J]. Journal of Kunming Medical University, 2023, 44(9): 62-68. doi: 10.12259/j.issn.2095-610X.S20230901

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The Analysis of Influence Factors on Platelet Antibody Production and Clinical Transfusion Effects

doi: 10.12259/j.issn.2095-610X.S20230901

Dept. of Blood Transfusion，The 1st Affiliated Hospital of Kunming Medical University， Kunming Yunnan 650032，China

Received Date: 2023-05-22
Available Online: 2023-09-23
Publish Date: 2023-09-30

Abstract

Abstract

Objective To analyze the platelet antibody detection results and the influence factors of 937 patients in our hospital, explore the impact of platelet antibodies on clinical transfusion effects, provide basis for the application value of platelet antibody detection, and ensure that platelet transfusion is more effective and safe. Methods From June 2019 to April 2021, samples from 937 patients were randomly collected from inpatients who applied for blood preparation or blood transfusion, and platelet antibodies were detected. The patients’ general clinical data were collected through the electronic medical record system and LIS system. Results 1. The positive rate of platelet antibody in patients with multiple transfusions was 13.23% , and the positive rate of platelet antibody correlated with the number of transfusions with statistically significant differences; 2. The positive rate of platelet antibody test was higher in women than in men （15.95% vs 10.57%, P < 0.05）; 3. The positive rate of platelet antibody test was higher in medical patient than in surgical patient （16.31% vs 3.88%, P < 0.05）, among which the top three department of medicine with positive platelet antibody test rates were the hematology department, the emergency department, and ICU （19.07% vs 18.42% vs 16.95%）; 4. For patients in the hematology department, the number of chemotherapy, the combined use of more than 2 types of chemotherapy drugs, and the number of previous transfusion of platelets were significantly correlated with the detection rate of platelet antibodies （P < 0.05）; 5. The positive rate of antibodies in the effective and ineffective groups of platelet transfusion was statistically different （P < 0.05）; 6. The detection rate of HLA antibodies among platelet antibodies in non-hemolytic febrile reactions was as high as 67.85% （19/28）. Conclusion 1. The production of platelet antibody is positively correlated with the number of blood transfusion, and the factors affecting the positive rate of platelet antibodies included: the number of platelet transfusions, female maternal history, the number of chemotherapy treatments in chemotherapy patients, and the use of chemotherapy drugs; 2. The investigation and study of platelet antibody detection has the enormous application value in the ineffectiveness of platelet transfusion, the assessment of transfusion efficacy in patients with hematologic diseases and chemotherapy, the establishment of transfusion strategy, and the diagnosis of non-hemolytic febrile transfusion adverse reactions; 3. The effect of Platelet transfusion can be significantly improved by coordinating platelets transfusion, and can effectively reduce the occurrence of ineffective platelets transfusion.
- Blood transfusion,
- Platelet antibodies,
- Ineffective platelet transfusion,
- Influence factors

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References(16)

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