Changes of Peripheral Blood Lymphocyte Subsets of Population De-adaptated from High Altitude

Liqun ZHANG; Mindong CHAI; Zhiqiang PAN; Yanfen ZHENG; Kun ZHAO; Xin ZHAO; Lin ZHANG; Ningping ZHANG

doi:10.12259/j.issn.2095-610X.S20231012

Volume 44 Issue 10

Oct. 2023

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Liqun ZHANG, Mindong CHAI, Zhiqiang PAN, Yanfen ZHENG, Kun ZHAO, Xin ZHAO, Lin ZHANG, Ningping ZHANG. Changes of Peripheral Blood Lymphocyte Subsets of Population De-adaptated from High Altitude[J]. Journal of Kunming Medical University, 2023, 44(10): 122-128. doi: 10.12259/j.issn.2095-610X.S20231012

Citation:

Liqun ZHANG, Mindong CHAI, Zhiqiang PAN, Yanfen ZHENG, Kun ZHAO, Xin ZHAO, Lin ZHANG, Ningping ZHANG. Changes of Peripheral Blood Lymphocyte Subsets of Population De-adaptated from High Altitude[J]. Journal of Kunming Medical University, 2023, 44(10): 122-128. doi: 10.12259/j.issn.2095-610X.S20231012

Citation:

Liqun ZHANG, Mindong CHAI, Zhiqiang PAN, Yanfen ZHENG, Kun ZHAO, Xin ZHAO, Lin ZHANG, Ningping ZHANG. Changes of Peripheral Blood Lymphocyte Subsets of Population De-adaptated from High Altitude[J]. Journal of Kunming Medical University, 2023, 44(10): 122-128. doi: 10.12259/j.issn.2095-610X.S20231012

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Changes of Peripheral Blood Lymphocyte Subsets of Population De-adaptated from High Altitude

doi: 10.12259/j.issn.2095-610X.S20231012

Dept. of Convalesce Unit 32261 of The Chinese People’s Liberation Army， Anning Yunnan 650307 China

Received Date: 2023-07-03
Available Online: 2023-09-12
Publish Date: 2023-10-25

Abstract

Abstract

Objective To understand the changes in peripheral blood lymphocyte subsets in individuals who have migrated to high-altitude low-oxygen environments and returned to lower altitude areas, and to explore the impact of high-altitude deadaptation on the immune function of healthy individuals. Methods The changes of peripheral blood lymphocyte subsets in 47 migrants within 15 days de-adaptated from high altitude were measured by flow cytometry. Results People with a residence time of ≥1 year in high-altitude areas had lower CD3+ T cell levels and higher B cell levels on the first day of returning to low-altitude regions compared to those with a residence time of < 1 year （P < 0.05）. On the 15th day of returning to low-altitude regions, people with a residence time of ≥1 year in high-altitude areas had higher B lymphocyte levels compared to those with a residence time of < 1 year （P < 0.01）. In the peripheral blood T lymphocyte subgroups of high-altitude residents returning to low-altitude regions after 15 days, the percentage of CD8+ T cells increased （P < 0.05）, the ratio of CD4+ T cells to CD8+ T cells decreased （P < 0.05）, the percentage of natural killer （NK） cells increased （P < 0.05）, and the percentage of cytokine-induced killer （CIK） cells increased （P < 0.01）. There was no statistically significant difference in CD3+ T cells, CD4+ T cells, and B cells （P > 0.05）. Conclusions Analysis of peripheral blood lymphocyte subgroups in populations adapted to high altitudes suggests that the duration of residence at high altitudes affects cellular and humoral immunity during the de-adaptation period. The percentage of CD8+ T lymphocytes, NK cells, and CIK cells in the peripheral blood of individuals during the de-adaptation period at high altitudes increases, indicating that the main effect of high-altitude de-adaptation is to affect the immune function of the body through cellular immunity and non-specific immune processes.
- High altitude de-adaptation,
- T lymphocyte,
- B lymphocyte,
- Natural killer cell,
- Cytokine‐induced killer cell

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References(37)

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