Volume 44 Issue 10
Oct.  2023
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Tiantian CHENG, Wensa YIN, Jia WANG, Yumei LU, Xuanyu CHEN, Shengjie NIE, Linlin LIU. Association between TMTC1 Gene Polymorphisms and Schizophrenia[J]. Journal of Kunming Medical University, 2023, 44(10): 161-167. doi: 10.12259/j.issn.2095-610X.S20231014
Citation: Tiantian CHENG, Wensa YIN, Jia WANG, Yumei LU, Xuanyu CHEN, Shengjie NIE, Linlin LIU. Association between TMTC1 Gene Polymorphisms and Schizophrenia[J]. Journal of Kunming Medical University, 2023, 44(10): 161-167. doi: 10.12259/j.issn.2095-610X.S20231014

Association between TMTC1 Gene Polymorphisms and Schizophrenia

doi: 10.12259/j.issn.2095-610X.S20231014
  • Received Date: 2023-07-26
    Available Online: 2023-09-07
  • Publish Date: 2023-10-25
  •   Objective  To explore the association between single nucleotide polymorphisms of TMTC1 gene and schizophrenia.   Methods  A total of 207 patients with schizophrenia and 186 healthy controls were included in the study. SNPscanTM multiplex SNP genotyping technology was used to perform genetic typing of 7 SNP loci in the TMTC1 gene. Differences in allele frequencies, genotypes, and haplotypes were compared, and the correlation between SNP loci and susceptibility to schizophrenia was analyzed under different genetic models.   Results  The genotype distribution of the 7 SNP sites loci is consistent with Hardy-Weinberg equilibrium. There was no statistically significant difference in the allele and genotype frequency distribution of the 7 loci between the two groups (P > 0.05). The polymorphisms of the 7 SNP loci under different genetic models are not associated with the risk of schizophrenia (P > 0.05). However, there is a high degree of linkage disequilibrium (LD) between rs10332 and rs16934358, rs10332 and rs2023588, rs16934358 and rs2023588, rs16934358 and rs7503.   Conclusion  The polymorphisms of the TMTC1 gene at rs7503, rs10332, rs2023588, rs16934358, rs2113879, rs679087, and rs4931240 sites are not associated with schizophrenia. Further analysis is needed by increasing the sample size and screening for new SNP loci.
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