A Study on Prognostic Value of Cellular Immunological Indicators in Omicron Variant Infected Elderly Severe Patients

Jiefu TANG; Dexing YANG; Shengzhe LIU; Qiang WANG; Kai FU; Zhenfang WANG; Ying LUAN; Min LI; Rong LIU

doi:10.12259/j.issn.2095-610X.S20231214

Volume 44 Issue 12

Dec. 2023

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Article Navigation > Journal of Kunming Medical University > 2023 > 44(12): 87-94

Jiefu TANG, Dexing YANG, Shengzhe LIU, Qiang WANG, Kai FU, Zhenfang WANG, Ying LUAN, Min LI, Rong LIU. A Study on Prognostic Value of Cellular Immunological Indicators in Omicron Variant Infected Elderly Severe Patients[J]. Journal of Kunming Medical University, 2023, 44(12): 87-94. doi: 10.12259/j.issn.2095-610X.S20231214

Citation:

Jiefu TANG, Dexing YANG, Shengzhe LIU, Qiang WANG, Kai FU, Zhenfang WANG, Ying LUAN, Min LI, Rong LIU. A Study on Prognostic Value of Cellular Immunological Indicators in Omicron Variant Infected Elderly Severe Patients[J]. Journal of Kunming Medical University, 2023, 44(12): 87-94. doi: 10.12259/j.issn.2095-610X.S20231214

Citation:

Jiefu TANG, Dexing YANG, Shengzhe LIU, Qiang WANG, Kai FU, Zhenfang WANG, Ying LUAN, Min LI, Rong LIU. A Study on Prognostic Value of Cellular Immunological Indicators in Omicron Variant Infected Elderly Severe Patients[J]. Journal of Kunming Medical University, 2023, 44(12): 87-94. doi: 10.12259/j.issn.2095-610X.S20231214

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A Study on Prognostic Value of Cellular Immunological Indicators in Omicron Variant Infected Elderly Severe Patients

doi: 10.12259/j.issn.2095-610X.S20231214

1.
Geriatric ICU，The 1st Affiliated Hospital of Kunming Medical University，Yunnan Kunming 650032
2.
Dept. of Emergency Internal Medicine，The 1st People's Hospital of Yunnan Province，Yunnan Kunming 650034，China

Received Date: 2023-09-13
Publish Date: 2023-12-25

Abstract

Abstract

Objective To investigate the characteristics of clinical cellular immunity and its relationship with prognosis in elderly patients with severe infection caused by Omicron variant. Methods The clinical data of 53 patients with Omicron variant infection admitted to the geriatric Intensive Care Unit of the First Affiliated Hospital of Kunming Medical University from December 2022 to February 2023 were retrospectively analyzed. The patients were divided into 22 survival cases and 31 death cases for comparison between the two groups. Logistic analysis is adopted to define the omicron variants of elderly severe infections prognostic factors and construct the ROC curve. Results Multivariate logistic analysis revealed that the independent risk factors were elevated IL-6（P = 0.043） and decreased absolute T lymphocyte count（P = 0.011）.AUC value of ROC of IL-6, absolute T lymphocyte count and IL-6 combined with absolute T lymphocyte count was 0.818, 0.796 and 0.887. Conclusion Elevated IL-6 and decreased absolute T lymphocyte count are independent risk factors for elderly severe patients with Omicron variant infections.
- Omicron variant,
- Prognosis,
- Cellular immunological indicators

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References(35)

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