Chemical Compounds Isolated from <i>Dendrobium crepidatum</i> and Their Bioactive Activities

Chenxi ZHUANG; Huimin WANG; Yaping CHEN; Rui ZHANG; Jinrong ZHENG; Meihong LI; Yupeng LI

doi:10.12259/j.issn.2095-610X.S20231231

Volume 44 Issue 12

Dec. 2023

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Chenxi ZHUANG, Huimin WANG, Yaping CHEN, Rui ZHANG, Jinrong ZHENG, Meihong LI, Yupeng LI. Chemical Compounds Isolated from Dendrobium crepidatum and Their Bioactive Activities[J]. Journal of Kunming Medical University, 2023, 44(12): 1-5. doi: 10.12259/j.issn.2095-610X.S20231231

Citation:

Chenxi ZHUANG, Huimin WANG, Yaping CHEN, Rui ZHANG, Jinrong ZHENG, Meihong LI, Yupeng LI. Chemical Compounds Isolated from Dendrobium crepidatum and Their Bioactive Activities[J]. Journal of Kunming Medical University, 2023, 44(12): 1-5. doi: 10.12259/j.issn.2095-610X.S20231231

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Chemical Compounds Isolated from Dendrobium crepidatum and Their Bioactive Activities

doi: 10.12259/j.issn.2095-610X.S20231231

Chenxi ZHUANG^{1, 2, 3},
Huimin WANG^{1, 4},
Yaping CHEN^{1, 3},
Rui ZHANG^{1, 3},
Jinrong ZHENG^{1, 3},
Meihong LI^{1, 3
,
,},
Yupeng LI^{1, 3
,
,}

1.
School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products，Kunming Medical University，Kunming Yunnan 650500
2.
School of Pharmacy，Honghe Health Vocational College，Honghe Yunnan 661100
3.
College of Modern Biomedical Industry，Kunming Medical University，Kunming Yunnan 650500
4.
Dept. of Pharmacy，Yunnan Infectious Disease Hospital，Kunming Yunnan 650301，China

Received Date: 2023-09-20
Available Online: 2023-12-22
Publish Date: 2023-12-25

Abstract

Abstract

Objective To study the chemical constituents from the herbs of Dendrobium crepidatum and identify its antitumor bioactive compounds. Methods The constituents were extracted by methyl alcohol and isolated by CC and Sephadex LH-20. Their structures were identified by spectroscopic analysis（¹H NMR, ¹³CNMR and EIMS）. The antitumor activity of the constituents was determined by MTT assay in vitro. Results 9 compouds were obtained and identified as p-hydroxybenzaldehyde（1）, p-methoxyphenol（2）, p-Hydroxybenzyl alcohol（3）, hydroquinone（4）, （24R）-ethylcholest-5-en-3-ol-7-one（5）, sinalexin（6）, bis（2-ethylhexyl） benzene-1, 2-dicarboxylate（7） , pinoresinol（8）, Chaenomin B（9）. The antitumor activity of compounds 5～9 was tested, and it was found that compound 9 had good inhibitory activity against A549 cell line. Conclusion Compounds 2～5, 7～8 were isolated from the herbs for the first time and compounds 6, 9 were isolated from this genus for the first time. IC₅₀ of 9 on A549 cell line is 29.35 μM.
- Dendrobium crepidatum,
- Chemical constituents,
- Bioactive activity

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