Volume 45 Issue 1
Jan.  2024
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Article Navigation >  Journal of Kunming Medical University  > 2024  >  45(1): 8-14
Yanqin RUAN, Maojuan LI, Limei HE, Ying SONG, Qiaoyun HUANG, Ying CHEN, Chang LIU. Screening of Special Abnormal Module Items in PRO Scale for Patients with Inflammatory Bowel Disease.[J]. Journal of Kunming Medical University, 2022, 43(3): 37-43. doi: 10.12259/j.issn.2095-610X.S20220310
Citation: Runan QI, Lei SHI, Shuyuan LIU, Jing LI, Li SHI. Correlation Analysis of HLA-DM Gene Polymorphisms with Polio Vaccine-induced Antibody Response[J]. Journal of Kunming Medical University, 2024, 45(1): 8-14. doi: 10.12259/j.issn.2095-610X.S20240102
shu

Correlation Analysis of HLA-DM Gene Polymorphisms with Polio Vaccine-induced Antibody Response

doi: 10.12259/j.issn.2095-610X.S20240102

  • Institute of Medical Biology，Chinese Academy of Medical Sciences & Peking Union Medical College，Kunming Yunnan 650118，China

  • Received Date: 2023-09-26
  • Publish Date: 2024-01-25
    Abstract
  •   Objective   To investigate the correlation between HLA-DM gene polymorphism and antibody response induced by poliomyelitis vaccine.   Methods   355 healthy infants aged 2 to 3 months in Guangxi Zhuang Autonomous Region were selected as the study objects, and 10 SNPs of DMA exon 3 and DMB exon 2/3 were genotyped by Sanger sequencing. The correlation between DMA and DMB genes and poliomyelitis vaccine-induced antibody response was analyzed at allele, genotype and haplotype levels.   Results   In the type I antibody response induced by polio vaccine, the frequencies of DMA*01:02, DMB*01:01, DMB*01:01/DMB*01:01 and DMA*01:02-DMB*01:01 were higher in the non-seroconversion group than in the seroconversion group（P < 0.05）. In the polio type II antibody response, the frequencies of DMA*01:02, DMA*01:02/DMA*01:02, DMB*01:01/DMB*01:01 and DMA*01:02-DMB*01:01 were higher in the non-seroconversion group than in the seroconversion group（ P < 0.05）.   Conclusion   Alleles DMA*01:02 and DMB*01:01 may be associated with type I and type II antibody responses induced by poliomyelitis vaccine.
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